S. Matsumoto

发表

Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.

Y. Ikeda, Masaharu Nakayama, C. Kitada, 2014, Journal of medicinal chemistry.

Phase I Study of NK012, a Novel SN-38–Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors

A. Ohtsu, Ken Kato, Y. Matsumura, 2010, Clinical Cancer Research.

Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors.

T. Onda, Y. Matsumura, T. Hamaguchi, 2006, Cancer research.

Metabolic Fate of NKH477 (2) : Blood Concentration, Distribution, Excretion and Effects on Drug-Metabolizing Enzyme System in Rats after Repeated Intravenous Administration

Y. Esumi, S. Ninomiya, K. Yamashita, 1998 .

Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.

J. Kunitomo, Masanori Watanabe, N. Amano, 2017, Bioorganic & medicinal chemistry.

Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors.

K. Ogawa, T. Kawamoto, Rei Okamoto, 2017, European journal of medicinal chemistry.

2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats.

S. Sasaki, Masaharu Nakayama, Naoki Tomita, 2010, Bioorganic & medicinal chemistry.

Development of a bioanalytical method for circulating human T cells in animals using Arthrobacter luteus-based quantitative polymerase chain reaction and its application in preclinical biodistribution studies

H. Hirabayashi, T. Higuchi, Syunsuke Yamamoto, 2020, Regenerative therapy.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis.

A. Kadotani, Kotaro Sakamoto, S. Sogabe, 2017, Biochemical and biophysical research communications.

A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).

K. Saikatendu, Louise M. Walsh, G. Ambrus, 2014, Journal of medicinal chemistry.

A new class of pentapeptide KISS1 receptor agonists with hypothalamic-pituitary-gonadal axis activation.

Y. Shimizu, C. Kitada, M. Yamaguchi, 2019, Bioorganic & medicinal chemistry letters.

Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility.

Y. Ikeda, Shunichirou Tsutsumi, M. Yamaguchi, 2016, Journal of medicinal chemistry.

Clinical Cancer esearch cer Therapy : Clinical se I Study of NK 012 , a Novel SN-38 – Incorporating Micellar R oparticle , in Adult Patients with Solid Tumors

A. Ohtsu, Ken Kato, Y. Matsumura, 2010 .

Highly-sensitive simultaneous quantitation of glucosylsphingosine and galactosylsphingosine in human cerebrospinal fluid by liquid chromatography/tandem mass spectrometry.

Y. Kosugi, Kentaro Otake, S. Matsumoto, 2022, Journal of pharmaceutical and biomedical analysis.

Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).

V. Feher, D. Hosfield, T. Kawamoto, 2013, Bioorganic & medicinal chemistry letters.

Regiospecific formations of thieno[3,2-a]indolizine and thieno[2,3-b]indolizine derivatives.

A. Kakehi,, S. Ito, S. Matsumoto, 1987 .

Electrohalogenation of propargyl acetates and amides to form the 1,1-dibromo-2-oxo functionality and a facile synthesis of furaneol

T. Inokuchi, S. Matsumoto, S. Torii, 1992 .

Preparation of New Nitrogen-Bridged Heterocycles. 19. Smooth Syntheses of Thieno[3,2-a]- and Thieno[2,3-b]indolizine Derivatives

A. Kakehi,, S. Ito, M. Shiohara, 1989 .

Identification of cytidine-5-triphosphate synthase1-selective inhibitory peptide from random peptide library displayed on T7 phage

H. Oki, Y. Ishibashi, S. Sogabe, 2017, Peptides.

High-Throughput Screening to Identify Inhibitors of DEAD Box Helicase DDX41

Masaharu Nakayama, T. Kawamoto, Atsushi Nakanishi, 2017, SLAS discovery : advancing life sciences R & D.

Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.

Y. Ikeda, M. Yamaguchi, Y. Takatsu, 2014, European journal of pharmacology.

Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.

K. Saikatendu, Tsuyoshi Ishii, T. Kawamoto, 2017, Biochemical and biophysical research communications.

Involvement of Rat and Human Organic Anion Transporter 3 in the Renal Tubular Secretion of Topotecan [(S)-9-Dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]

I. Tamai, Kenji Yoshida, N. Ishiguro, 2007, Journal of Pharmacology and Experimental Therapeutics.

Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells

H. Hirabayashi, Syunsuke Yamamoto, A. Goto, 2020, Scientific Reports.

Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration.

Ikumi Chisaki, H. Hirabayashi, Syunsuke Yamamoto, 2021, Drug metabolism and pharmacokinetics.

Transcellular transport of oral cephalosporins in human intestinal epithelial cells, Caco-2: interaction with dipeptide transport systems in apical and basolateral membranes.

H. Saito, K. Inui, S. Matsumoto, 1994, The Journal of pharmacology and experimental therapeutics.

Quantitative application of flow cytometry for the analysis of circulating human T cells: A preclinical pharmacokinetic study.

H. Hirabayashi, Syunsuke Yamamoto, S. Matsumoto, 2019, Drug metabolism and pharmacokinetics.

Establishment of in vitro P-glycoprotein inhibition assay and its exclusion criteria to assess the risk of drug-drug interaction at the drug discovery stage.

H. Sugimoto, N. Amano, H. Hirabayashi, 2011, Journal of pharmaceutical sciences.

Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity.

Masaharu Nakayama, H. Matsumoto, C. Kitada, 2013, Journal of medicinal chemistry.

Serum stability of selected decapeptide agonists of KISS1R using pseudopeptides.

Masaharu Nakayama, H. Matsumoto, C. Kitada, 2012, Bioorganic & medicinal chemistry letters.

Highly specific, quantitative polymerase chain reaction probe for the quantification of human cells in cynomolgus monkeys.

H. Hirabayashi, Syunsuke Yamamoto, S. Matsumoto, 2020, Drug metabolism and pharmacokinetics.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Toshimasa Tanaka, T. Kawamoto, M. Yamaguchi, 2008, Bioorganic & medicinal chemistry.

Identification of AHCY inhibitors using novel high-throughput mass spectrometry.

J. Lawson, T. Kawamoto, H. Kimura, 2017, Biochemical and biophysical research communications.