Akira Takeshita

发表

New Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E-Knockout Mice

C. Kataoka, K. Egashira, S. Inoue, 2001, Circulation.

Role of Monocyte Chemoattractant Protein-1 in Cardiovascular Remodeling Induced by Chronic Blockade of Nitric Oxide Synthesis

H. Shimokawa, T. Yoshimura, K. Egashira, 2000, Circulation.

Antiinflammatory and Antiarteriosclerotic Actions of HMG-CoA Reductase Inhibitors in a Rat Model of Chronic Inhibition of Nitric Oxide Synthesis

C. Kataoka, K. Egashira, S. Inoue, 2001, Circulation research.

Inter-individual relationships in empathic traits and feedback-related fronto-central brain activity: an event-related potential study

S. Watanuki, Takayuki Nishimura, Y. Motomura, 2015, Journal of Physiological Anthropology.

Peroxisome Proliferator-Activated Receptorg Activators Downregulate Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

K. Takeda, T. Tokunou, T. Ichiki, 2000 .

Prostaglandin E2 Stimulates AP-1-Mediated CD14 Expression in Mouse Macrophages Via Cyclic AMP-Dependent Protein Kinase A1

S. Hanazawa, H. Iwahashi, Akira Takeshita, 2000, The Journal of Immunology.

Interaction between valence of empathy and familiarity: is it difficult to empathize with the positive events of a stranger?

S. Watanuki, Takayuki Nishimura, Y. Motomura, 2015, Journal of Physiological Anthropology.

Tyrosine Kinase Inhibitor Suppresses Coronary Arteriosclerotic Changes and Vasospastic Responses Induced by Chronic Treatment with Interleukin-lf in Pigs In Vivo changes and vasospastic responses to autacoids

H. Shimokawa, Y. Fukumoto, K. Egashira, 2022 .

Involvement of Inducible Nitric Oxide Synthase in

H. Shimokawa, A. Feldman, H. Tsutsui, 2002 .

Rho-Kinase Mediates Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression in Rat Vascular Smooth Muscle Cells

K. Takeda, K. Kaibuchi, H. Shimokawa, 2001, Hypertension.

Stress Testing and Electron Beam Computed Tomography for Evaluation of Patients With Suspected Coronary Artery Disease

H. Shimokawa, K. Morishige, Akira Takeshita, 2016 .

Critical Role of Rho-Kinase and MEK/ERK Pathways for Angiotensin II-Induced Plasminogen Activator Inhibitor Type-1 Gene Expression

K. Takeda, H. Shimokawa, T. Tokunou, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Identification, Characterization, and Functional Analysis of Heart-specific Myosin Light Chain Phosphatase Small Subunit*

J. Nishimura, H. Kanaide, T. Arimura, 2001, The Journal of Biological Chemistry.

Positive Inotropic Effects of Calcium Sensitizers on Normal and Failing Cardiac Myocytes

K. Egashira, S. Hayashidani, H. Tsutsui, 2001, Journal of cardiovascular pharmacology.

Tyrosine kinase inhibitor suppresses the (re)stenotic changes of the coronary artery after balloon injury in pigs 1

H. Shimokawa, Y. Fukumoto, K. Egashira, 1997 .

Rho-Kinase Is Involved in Macrophage-Mediated Formation of Coronary Vascular Lesions in Pigs In Vivo

K. Kaibuchi, K. Egashira, Y. Eto, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction

D. Kang, H. Utsumi, S. Hayashidani, 2001, Circulation research.

Transcriptional Regulation by Transforming Growth Factor β of the Expression of Retinoic Acid and Retinoid X Receptor Genes in Osteoblastic Cells Is Mediated through AP-1*

S. Kitano, S. Hanazawa, K. Ozaki, 1996, The Journal of Biological Chemistry.

Thyroid Hormone Response Elements Differentially Modulate the Interactions of Thyroid Hormone Receptors with Two Receptor Binding Domains in the Steroid Receptor Coactivator-1*

Y. Liu, A. Takeshita, N. Koibuchi, 1998, The Journal of Biological Chemistry.

TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1*

N. Koibuchi, C. Suen, W. Chin, 1997, The Journal of Biological Chemistry.

Overexpression of eNOS in NTS Causes Hypotension and Bradycardia In Vivo

Y. Hirooka, K. Sakai, H. Shigematsu, 2000, Hypertension.

Anti‐monocyte chemoattractant protein‐1 gene therapy inhibits vascular remodeling in rats: blockade of MCP‐1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis

Y. Kaneda, R. Morishita, K. Sueishi, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Transforming growth factor-beta inhibits lipopolysaccharide-stimulated expression of inflammatory cytokines in mouse macrophages through downregulation of activation protein 1 and CD14 receptor expression.

S. Hanazawa, K. Imai, Akira Takeshita, 2000, Infection and immunity.

1α,25-Dehydroxyvitamin D3 Synergism toward Transforming Growth Factor-β1-induced AP-1 Transcriptional Activity in Mouse Osteoblastic Cells via Its Nuclear Receptor*

A. Takeshita, S. Kitano, S. Hanazawa, 1998, The Journal of Biological Chemistry.

Adenovirus-Mediated Transfer of Dominant-Negative Rho-Kinase Induces a Regression of Coronary Arteriosclerosis in Pigs In Vivo

K. Kaibuchi, H. Shimokawa, Y. Eto, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Recurrent Myocardial Infarction Provoked by Multiple Giant Coronary Aneurysms A Case Report

A. Takeshita, H. Shimokawa, Y. Urabe, 1996, Angiology.

Angiotensin II Stimulates Mitogen-activated Protein Kinases and Protein Synthesis by a Ras-independent Pathway in Vascular Smooth Muscle Cells*

A. Takeshita, H. Ueno, M. Yokoyama, 1997, The Journal of Biological Chemistry.

Chronic inhibition of nitric oxide synthesis in rats increases aortic superoxide anion production via the action of angiotensin II

A. Takeshita, C. Kataoka, K. Egashira, 2000, Journal of hypertension.

Downregulation of Angiotensin II Type 1 Receptor by Hydrophobic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors in Vascular Smooth Muscle Cells

K. Takeda, A. Takeshita, H. Shimokawa, 2001, Arteriosclerosis, thrombosis, and vascular biology.

cAMP Response Element–Binding Protein Mediates Thrombin-Induced Proliferation of Vascular Smooth Muscle Cells

K. Takeda, A. Takeshita, T. Tokunou, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Regulation of the Transcriptional Activity of the Peroxisome Proliferator-activated Receptor α by Phosphorylation of a Ligand-independent trans-Activating Domain*

A. Burger, C. Meier, C. Siegrist-Kaiser, 1999, The Journal of Biological Chemistry.

TGF‐β inhibits lipopolysaccharide‐stimulated activity of c‐Jun N‐terminal kinase in mouse macrophages

S. Hanazawa, K. Imai, Akira Takeshita, 1999, FEBS letters.

Inter-individual relationships in empathic traits and feedback-related fronto-central brain activity: an event-related potential study

S. Watanuki, Takayuki Nishimura, Y. Motomura, 2015, Journal of Physiological Anthropology.

In vivo Gene Transfer of Dominant‐Negative Rho‐Kinase Induces Regression of Coronary Arteriosclerosis in Pigs

A. Takeshita, K. Kaibuchi, H. Shimokawa, 2001, Annals of the New York Academy of Sciences.

Effects of ACE Inhibition on Left Ventricular Failure and Oxidative Stress in Dahl Salt‐Sensitive Rats

A. Takeshita, H. Utsumi, S. Hayashidani, 2001, Journal of cardiovascular pharmacology.

Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-α-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells

H. Shinoda, Ken Matsumoto, K. Miyazawa, 2005 .

Combination of a Brief Irrigation With Tissue Factor Pathway Inhibitor (TFPI) and Adenovirus-Mediated Local TFPI Gene Transfer Additively Reduces Neointima Formation in Balloon-Injured Rabbit Carotid Arteries

A. Takeshita, H. Ueno, Y. Asada, 2001, Circulation.

Central role of vascular smooth muscle hyperreactivity in coronary hyperconstriction after balloon injury in miniature pigs

K. Egashira, T. Kuga, Y. Ohara, 1997, Coronary artery disease.

Glibenclamide decreases basal coronary blood flow in anesthetized dogs.

A. Takeshita, H. Tomoike, Teisuke Takahashi, 1992, The American journal of physiology.

Downregulation of Angiotensin II Type 1 Receptor by Hydrophobic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors in Vascular Smooth Muscle Cells

K. Takeda, H. Shimokawa, T. Tokunou, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Induction of interleukin-6 expression by angiotensin II in rat vascular smooth muscle cells.

A. Takeshita, T. Ichiki, Y. Funakoshi, 1999, Hypertension.

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.

H Shimokawa, A. Takeshita, H. Shimokawa, 2000, The Journal of clinical investigation.

Sarpogrelate, a selective 5-HT2A serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model.

A. Takeshita, H. Shimokawa, K. Egashira, 2000, Journal of cardiovascular pharmacology.

A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats.

T. Nakamura, A. Takeshita, Toru Nakamura, 2000, Human gene therapy.

Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium.

A. Takeshita, D. Kang, H. Utsumi, 1999, Circulation research.

TGF-beta induces expression of monocyte chemoattractant JE/monocyte chemoattractant protein 1 via transcriptional factor AP-1 induced by protein kinase in osteoblastic cells.

A. Takeshita, S. Kitano, S. Hanazawa, 1995, Journal of immunology.

Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension.

A. Takeshita, K. Kaibuchi, H. Shimokawa, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Renin-angiotensin system is involved in the mechanism of increased serum asymmetric dimethylarginine in essential hypertension.

A. Takeshita, K. Egashira, A. Ito, 2001, Japanese circulation journal.

Downregulation of angiotensin II type 1 receptor by all-trans retinoic acid in vascular smooth muscle cells.

K. Takeda, A. Takeshita, T. Ichiki, 2000, Hypertension.

Downregulation of angiotensin II type 1 receptor gene transcription by nitric oxide.

A. Takeshita, T. Ichiki, Y. Funakoshi, 1998, Hypertension.

Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.

A. Takeshita, K. Kaibuchi, H. Shimokawa, 2000, Circulation.

Importance of endothelium-derived hyperpolarizing factor in human arteries.

A. Takeshita, H. Shimokawa, K. Egashira, 1997, The Journal of clinical investigation.

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.

A. Takeshita, H. Shimokawa, Y. Fukumoto, 1996, The Journal of clinical investigation.

Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin).

A. Takeshita, Y. Hirooka, S. Setoguchi, 2001, The American journal of cardiology.

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.

A. Takeshita, K. Kaibuchi, H. Shimokawa, 1999, Cardiovascular research.

Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs.

Y. Yazaki, A. Takeshita, Y. Yonemitsu, 1997, Journal of cardiovascular pharmacology.

Three-year follow-up of the Japanese patients with microvascular angina attributable to coronary microvascular spasm.

A. Takeshita, M. Mohri, Akira Takeshita, 2001, International journal of cardiology.

Venous distensibility during pregnancy. Comparisons between normal pregnancy and preeclampsia.

A. Takeshita, T. Imaizumi, H. Nakano, 1994, Hypertension.

The role of fibroblast growth factor-2 in the vascular effects of interleukin-1 beta in porcine coronary arteries in vivo.

A. Takeshita, K. Sueishi, H. Shimokawa, 1996, Cardiovascular research.

Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease.

A. Takeshita, Y. Hirooka, H. Shimokawa, 1999, Journal of cardiovascular pharmacology.

The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation.

M. Fujishima, A. Takeshita, H. Shimokawa, 1996, Journal of cardiovascular pharmacology.

Job strain, Type A behavior pattern, and the prevalence of coronary atherosclerosis in Japanese working men.

Y. Liu, A. Takeshita, S. Koyanagi, 2000, Journal of psychosomatic research.

Adenovirus-mediated expression of the secreted form of basic fibroblast growth factor (FGF-2) induces cellular proliferation and angiogenesis in vivo.

A. Takeshita, H. Ueno, H. Yamamoto, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P.

M. Sugimachi, A. Takeshita, Y. Hirooka, 1995, Hypertension.

Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.

A. Takeshita, H. Shimokawa, K. Egashira, 1997, Circulation.

Differentiation Between Aberrant Ventricular Conduction and Ventricular Ectopy in Atrial Fibrillation Using RR Interval Scattergram

M. Sugimachi, K. Sunagawa, K. Egashira, 1993, Circulation.

MAPKs, activator protein-1 and nuclear factor-κB mediate production of interleukin-1β-stimulated cytokines, prostaglandin E₂ and MMP-1 in human periodontal ligament cells.

A. Takeshita, Matsuo Yamamoto, Makoto Kobayashi, 2011, Journal of periodontal research.

Cell cycle--dependent expression of L- and T-type Ca2+ currents in rat aortic smooth muscle cells in primary culture.

A. Takeshita, H. Kanaide, T. Kuga, 1996, Circulation research.

Short-term estrogen administration ameliorates dobutamine-induced myocardial ischemia in postmenopausal women with coronary artery disease.

A. Takeshita, H. Shimokawa, M. Alpaslan, 1997, Journal of the American College of Cardiology.

Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats.

A. Takeshita, H. Shimokawa, H. Yamamoto, 1998, Hypertension.

Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.

A. Takeshita, K. Sueishi, H. Shimokawa, 1997, The Journal of clinical investigation.

Role of coronary vasospasm in the pathogenesis of myocardial infarction: study in patients with no significant coronary stenosis.

A. Takeshita, S. Koyanagi, T. Fukai, 1993, American heart journal.

Effect of nitroglycerin on coronary collateral function during exercise evaluated by quantitative analysis of thallium-201 single photon emission computed tomography.

A. Takeshita, S. Koyanagi, M. Nakamura, 1991, American heart journal.

Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.

J. Oyama, A. Takeshita, H. Shimokawa, 1998, The Journal of clinical investigation.

Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels.

A. Takeshita, H. Shimokawa, T. Yoshimura, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Multiple atherosclerotic coronary aneurysms in association with acute myocardial infarction.

A. Takeshita, M. Nakamura, A. Mitsutake, 1982, Japanese heart journal.

Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-alpha-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells.

A. Takeshita, S. Kitano, S. Hanazawa, 1994, The Journal of biological chemistry.

CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts

A. Takeshita, S. Kitano, S. Hanazawa, 1996, Infection and immunity.

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

A. Takeshita, H. Shimokawa, Y. Fukumoto, 2005, Heart.

Inhibition of Myosin Phosphatase by Upregulated Rho-Kinase Plays a Key Role for Coronary Artery Spasm in a Porcine Model With Interleukin-1β

K. Kaibuchi, Y. Fukata, Y. Kawano, 2000 .

Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1 beta in pigs in vivo.

A. Takeshita, H. Shimokawa, Y. Fukumoto, 1995, The Journal of clinical investigation.

Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model.

A. Takeshita, H. Shimokawa, K. Egashira, 1994, Circulation.

Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo.

J. Oyama, A. Takeshita, H. Shimokawa, 1999, Cardiovascular research.

Role of endothelium-derived nitric oxide in coronary vasodilatation induced by pacing tachycardia in humans.

A. Takeshita, M. Mohri, Y. Katsuda, 1996, Circulation research.

Apical segmental dysfunction in hypertrophic cardiomyopathy: subgroup with unique clinical features.

A. Takeshita, T. Imaizumi, M. Nakamura, 1990, Journal of the American College of Cardiology.