T. Aicher

发表

Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK).

J. Gao, S. S. Shetty, T. Aicher, 1999, Bioorganic & medicinal chemistry letters.

A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.

Koki Kato, Yoshihisa Nakada, Toshihiro Yamamoto, 2011, European journal of pharmacology.

Novel acyl coenzyme A (CoA): diacylglycerol acyltransferase-1 inhibitors: synthesis and biological activities of diacylethylenediamine derivatives.

T. Turner, Koki Kato, Stephen S. Gonzales, 2010, Bioorganic & medicinal chemistry.

Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.

Ashutosh Kumar Singh, F. Sullivan, E. Wallace, 2019, Bioorganic & medicinal chemistry.

Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.

A. Cheng, P. Coward, J. Medina, 2016, ACS medicinal chemistry letters.

Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as hypoglycemic agents.

J. Gao, R. Simpson, R. Deems, 1998, Journal of medicinal chemistry.

Discovery of 2-pyridylureas as glucokinase activators.

M. McVean, K. Condroski, W. deWolf, 2014, Journal of medicinal chemistry.

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer.

P. Toogood, Tao Zheng, G. Glick, 2021, Journal of medicinal chemistry.

SYNTHESIS OF CHIRAL TETRAHYDROPYRROLO2,1-BTHIAZOL-5(6H)-ONES

Howard C. Smith, T. Aicher, D. C. Knorr, 1998 .

Synthetic studies towards halichondrins

Y. Kishi, T. Aicher, 1987 .

Total synthesis of halichondrin B and norhalichondrin B

Craig J. Forsyth, Sun Ho Jung, Francis G. Fang, 1992 .

Synthetic Studies towards Halichondrins: Synthesis of the C.27–C.38 Segment

C. Forsyth, Y. Kishi, S. Jung, 1992 .

Novel therapeutics and targets for the treatment of diabetes

A. Celeste, M. McVean, S. Boyd, 2010, Expert review of clinical pharmacology.

C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.

P. Coward, Jaehyeon Park, M. Véniant, 2014, ACS medicinal chemistry letters.

RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

T. Mcclanahan, D. Zaller, E. Murphy, 2016, The Journal of allergy and clinical immunology.

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

P. Toogood, K. Majchrzak, G. Glick, 2016, Oncoimmunology.

Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid.

J. Foley, D. A. Otero, R. Simpson, 1999, Journal of medicinal chemistry.

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.

D. Zaller, I. Wang, K. MacIsaac, 2016, Cell reports.

Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists.

P. Toogood, G. Glick, L. Carter, 2015, Nature chemical biology.

Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.

W. H. Wang, G R Bebernitz, T D Aicher, 2000, Journal of medicinal chemistry.

Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.

T D Aicher, J L Stanton, J Gao, 2000, Journal of medicinal chemistry.

Diverse mechanisms of inhibition of pyruvate dehydrogenase kinase by structurally distinct inhibitors.

T. R. Vedananda, P. Bell, T. Aicher, 2000, Biochimica et biophysica acta.

Perhydroquinolylbenzamides as novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

A. Jeng, P. Kukkola, J. Stanton, 2005, Journal of medicinal chemistry.

Identification of a new class of glucokinase activators through structure-based design.

K. Condroski, W. deWolf, W. Voegtli, 2013, Journal of medicinal chemistry.

Corrigendum: Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists.

P. Toogood, G. Glick, L. Carter, 2015, Nature Chemical Biology.

Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.

Kirk W. Johnson, M. Blanco, D. Benesh, 2017, Bioorganic & medicinal chemistry letters.

Novel acyl coenzyme A (CoA): diacylglycerol acyltransferase-1 inhibitors: synthesis and biological activities of diacylethylenediamine derivatives.

T. Turner, Koki Kato, Stephen S. Gonzales, 2010, Bioorganic & medicinal chemistry.

Nucleophilic cleavage of spiroactivated cyclopropanes.1. Kinetic and thermodynamic parameters for reaction of 6,6-dimethyl-2-phenyl-5,7-dioxaspiro[2,5]octane-4,8-dione (2) with pyridine.

M. McKinney, T. Aicher, K. G. Kremer, 1984 .

C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.

P. Coward, Jaehyeon Park, M. Véniant, 2014, ACS medicinal chemistry letters.