S. Nair

发表

Cycloaromatization of a solvolytically generated ene-yne-allene

R. Cunico, S. Nair, R. F. Cunico, 1997 .

The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.

A. Fanjul, P. Rejto, G. Paderes, 2010, Bioorganic & medicinal chemistry letters.

Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier

M. Spilker, Meirong Xu, A. Yang, 2011, Molecular Cancer Therapeutics.

Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models.

P. Wells, E. Rui, Chau Almaden, 2009, Experimental eye research.

Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin.

Elizabeth A. Amin, Oliver E. Hutt, R. Himes, 2009, Bioorganic & medicinal chemistry letters.

Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.

Elizabeth A. Amin, Oliver E. Hutt, R. Himes, 2008, Bioorganic & medicinal chemistry letters.

Practical syntheses of the C12–C21 epothilone subunit via catalytic asymmetric reductions: Itsuno–Corey oxazaborolidine reduction and asymmetric Noyori hydrogenation

G. Georg, E. Reiff, S. Nair, 2004 .

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry.

M. Tran-Dube, J. Warmus, M. Collins, 2015, The Journal of organic chemistry.

Multifaceted Substrate-Ligand Interactions Promote the Copper-Catalyzed Hydroboration of Benzylidenecyclobutanes and Related Compounds.

P. Liu, Peng Liu, K. Engle, 2020, ACS catalysis.

Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine.

V. Stella, G. Georg, D. VanderVelde, 2010, Journal of pharmaceutical sciences.

Chapter 6:Influence of Aromatic Rings on ADME Properties of Drugs

D. Dalvie, C. Loi, Ping Kang, 2010 .

Recent progress on third generation covalent EGFR inhibitors.

Hengmiao Cheng, S. Nair, B. Murray, 2016, Bioorganic & medicinal chemistry letters.

Latanoprost (Xalatan): A Prostanoid FP Agonist for Glaucoma

S. Nair, K. Henegar, 2010 .

1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for ortho/meta-substituted arenes

Julien C. Vantourout, J. Mousseau, P. Baran, 2021, Proceedings of the National Academy of Sciences.

Rapid entry into the cryptophycin core via an acyl-beta-lactam macrolactonization: total synthesis of cryptophycin-24.

G. Georg, S. Nair, M. Eggen, 2001, Organic letters.

Total synthesis of cryptophycin-24 (Arenastatin A) amenable to structural modifications in the C16 side chain.

G. Georg, L. Bhat, C. Mossman, 2000, The Journal of organic chemistry.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Paolo Vicini, Deepak Dalvie, Chengyi Zhang, 2017, Journal of medicinal chemistry.

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

Deepak Dalvie, Michael Zientek, Rose Ann Ferre, 2016, Journal of medicinal chemistry.

Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.

N. Sach, M. McTigue, Sergei L Timofeevski, 2023, Journal of medicinal chemistry.

Diastereoselective access to substituted 4-aminopiperidines via a pyridine reduction approach

N. Sach, G. Gallego, Graham L. Smith, 2016 .

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.

A. Fanjul, P. Rejto, M. Edwards, 2013, Bioorganic & medicinal chemistry letters.

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.

A. Fanjul, M. Edwards, J. Ermolieff, 2009, Bioorganic & medicinal chemistry letters.

Total Synthesis and Evaluation of C 26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin

Elizabeth A. Amin, David, R. Himes, 2009 .

Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization

R. Himes, S. Nair, R. Vidya, 2003 .

Recent progress on third generation covalent EGFR inhibitors.

Hengmiao Cheng, S. Nair, B. Murray, 2016, Bioorganic & medicinal chemistry letters.

K. Gajiwala, N. Sach, Sherry L. Niessen, 2016, Journal of medicinal chemistry.