A. Otomo

发表

Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking

Y. Itoyama, S. Hadano, J. Ikeda, 2010, PloS one.

Defective relocalization of ALS2/alsin missense mutants to Rac1‐induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

S. Hadano, J. Ikeda, A. Otomo, 2011, FEBS letters.

Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function

H. Shang, S. Hadano, S. Nakagawa, 2018, The Journal of Biological Chemistry.

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.

H. Shang, S. Hadano, Masayuki Yamamoto, 2016, Human molecular genetics.

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice

Y. Itoyama, S. Hadano, J. Ikeda, 2008, Experimental Neurology.

PACT/PRKRA and p53 regulate transcriptional activity of DMRT1

S. Takada, Michihiko Ito, N. Takamatsu, 2020, Genetics and molecular biology.

SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron

S. Hadano, T. Yanagawa, E. Warabi, 2022, Neurochemistry International.

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model

G. Sobue, H. Shang, S. Hadano, 2018, Molecular Brain.

Different Human Copper-Zinc Superoxide Dismutase Mutants, SOD1G93A and SOD1H46R, Exert Distinct Harmful Effects on Gross Phenotype in Mice

H. Shang, S. Hadano, Y. Iwasaki, 2012, PloS one.

Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice

S. Hadano, J. Ikeda, Y. Iwakura, 2010, Neuroscience Research.

GRP78 Suppresses Lipid Peroxidation and Promotes Cellular Antioxidant Levels in Glial Cells following Hydrogen Peroxide Exposure

Masahiko Watanabe, J. Mochida, H. Terayama, 2014, PloS one.

Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies

S. Hadano, G. Caron, G. Ermondi, 2022, Molecules.

Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain.

J. Ikeda, A. Otomo, R. Kunita, 2002, Genomics.

The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.

S. Hadano, Shun Mitsui, A. Otomo, 2021, Biochemical and biophysical research communications.

Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B

S. Hadano, M. Ohtsuka, Masayuki Tanaka, 2020, PloS one.

Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling

H. Okano, S. Hadano, H. Miyajima, 2018, eNeuro.

Human PZP and common marmoset A2ML1 as pregnancy related proteins

T. Shiina, E. Sasaki, F. Kametani, 2020, Scientific Reports.

Sexually dimorphic expression of Dmrt1 and γH2AX in germ stem cells during gonadal development in Xenopus laevis

Michihiko Ito, N. Takamatsu, K. Fujitani, 2016, FEBS open bio.

De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs

S. Hadano, A. Umezawa, A. Fukuda, 2022, Cell reports methods.

Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

S. Beck, S. Mano, H. Inoko, 2020, EBioMedicine.

Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

S. Beck, S. Mano, H. Inoko, 2018, bioRxiv.

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

H. Okano, G. Sobue, H. Saya, 2018, Nature Medicine.

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.

Shuh Narumiya, Takeharu Nishimoto, Asako Otomo, 2003, Human molecular genetics.

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

H. Okano, G. Sobue, H. Saya, 2018, Nature Medicine.

Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

S. Hadano, A. Otomo, Lei Pan, 2012, Neurology research international.

Effects of busulfan sustained-release emulsion on depletion and repopulation of primordial germ cells in early chicken embryos.

K. Nirasawa, H. Kagami, T. Tagami, 2009 .

The production of avian germline chimeras by the trans- fer of primordial germ cells (PGCs) into recipient embryos in the chimeric gonads. Depletion of the endogenous PGCs of the recipient embryo prior to transfer of exoge-

K. Nirasawa, H. Kagami, T. Tagami, 2009 .

Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration

Asako Otomo, S. Hadano, J. Ikeda, 2007, Neurochemistry International.

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

S. Scherer, Robert H. Brown, M. Hayden, 2001, Nature Genetics.

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

S. Scherer, Robert H. Brown, M. Hayden, 2001, Nature Genetics.

Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking*

Asako Otomo, S. Hadano, J. Ikeda, 2004, Journal of Biological Chemistry.

SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells

H. Shang, S. Hadano, Xueping Chen, 2020, eNeurologicalSci.

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model

G. Sobue, H. Shang, S. Hadano, 2018, Molecular Brain.

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device

S. Hadano, Shun Mitsui, A. Otomo, 2021, Neuroscience Research.

Human PZP and common marmoset A2ML1 as pregnancy related proteins

T. Shiina, E. Sasaki, F. Kametani, 2020, Scientific Reports.

Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1 H46R transgenic mouse model of ALS

S. Hadano, M. Ohtsuka, A. Otomo, 2011, Neuroscience Research.

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis*

S. Hadano, J. Ikeda, A. Otomo, 2007, Journal of Biological Chemistry.

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.

S. Hadano, J. Ikeda, H. Osuga, 2007, Biochemical and biophysical research communications.

ALS2CL, the novel protein highly homologous to the carboxy‐terminal half of ALS2, binds to Rab5 and modulates endosome dynamics

S. Hadano, J. Ikeda, Y. Yanagisawa, 2004, FEBS letters.

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking.

Robert H. Brown, S. Hadano, J. Shefner, 2006, Human molecular genetics.

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth.

S. Hadano, J. Ikeda, H. Osuga, 2008, Biochemical and biophysical research communications.

Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures

S. Hadano, T. Fujie, S. Takeoka, 2019, bioRxiv.

Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes.

S. Hadano, Shun Mitsui, A. Otomo, 2022, Biochemical and biophysical research communications.

ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.

S. Hadano, M. Fukuda, Shun Mitsui, 2020, Biochemical and biophysical research communications.

An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons

H. Kimura, S. Hadano, S. Yokoyama, 2019, Biomicrofluidics.

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.

H. Shang, S. Hadano, Masayuki Yamamoto, 2016, Human molecular genetics.

Journal Pre-proof a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron

S. Hadano, E. Warabi, Shun Mitsui, 2022 .

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice

Y. Itoyama, S. Hadano, J. Ikeda, 2008, Experimental Neurology.