Christine Sastri

Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors.

Kristin L. Andrews, B. Herberich, Matthew R. Lee, 2016, Bioorganic & medicinal chemistry letters.

The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.

Kristin L. Andrews, B. Herberich, Matthew R. Lee, 2015, Bioorganic & medicinal chemistry letters.

The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.

Matthew R. Lee, Xin Huang, A. Tasker, 2015, Bioorganic & medicinal chemistry letters.

Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia

Matthew J. Rardin, K. Metzeler, K. Spiekermann, 2020, Molecular Cancer Therapeutics.

A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation.

J. McCarter, J. Lipford, D. Mohl, 2017, Journal of medicinal chemistry.

Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.

K. Rex, J. Canon, B. Herberich, 2019, Journal of medicinal chemistry.

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

K. Rex, B. Herberich, Matthew R. Lee, 2016, Journal of medicinal chemistry.

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.

K. Rex, B. Herberich, Matthew R. Lee, 2016, ACS medicinal chemistry letters.

Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors.

Matthew R. Lee, A. Tasker, Bin Wu, 2015, Bioorganic & medicinal chemistry letters.