D. Ye

D. Tester, M. Ackerman, J. Giudicessi, 2020, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

Lidocaine attenuation testing: An in vivo investigation of putative LQT3-associated variants in the SCN5A-encoded sodium channel.

Jamie D. Kapplinger, M. Ackerman, J. Bos, 2017, Heart rhythm.

Promise and Potential Peril With Lumacaftor for the Trafficking Defective Type 2 Long-QT Syndrome-Causative Variants, p.G604S, p.N633S, and p.R685P, Using Patient-Specific Re-Engineered Cardiomyocytes

D. Tester, M. Ackerman, D. Ye, 2020, Circulation. Genomic and precision medicine.

activation by 14,15-epoxyeicosatrienoic acid channel ATP Mechanism of rat mesenteric arterial K

J. Falck, T. Lu, Hon-chi Lee, 2016 .

Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid.

J. Falck, T. Lu, Hon-chi Lee, 2006, American journal of physiology. Heart and circulatory physiology.

A Phenotype-Enhanced Variant Classification Framework to Decrease the Burden of Missense Variants of Uncertain Significance in Type 1 Long QT Syndrome.

A. Wilde, D. Tester, M. Ackerman, 2021, Heart rhythm.

Utilizing the Genome Aggregation Database, Computational Pathogenicity Prediction Tools, and Patch Clamp Heterologous Expression Studies to Demote Previously Published Type 1 Long QT Syndrome Mutations from Pathogenic to Benign

Jamie D. Kapplinger, D. Tester, M. Ackerman, 2019 .

A novel functional variant residing outside the SCN5A-encoded Nav1.5 voltage-sensing domain causes multifocal ectopic Purkinje-related premature contractions

Wei Zhou, D. Tester, M. Ackerman, 2021, HeartRhythm case reports.

Novel Timothy syndrome mutation leading to increase in CACNA1C window current.

Michael J Ackerman, Charles Antzelevitch, C. Antzelevitch, 2015, Heart rhythm.

Induced Pluripotent Stem Cell–Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations

S. Ommen, H. Schaff, D. Tester, 2019, Journal of Cardiovascular Translational Research.

Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome.

P. Schwartz, C. Antzelevitch, D. Tester, 2011, Heart rhythm.

Utilization of the Genome Aggregation Database, In Silico Tools, and Heterologous Expression Patch Clamp Studies to Identify and Demote Previously Published Type 2 Long QT Syndrome-Causative Variants from Pathogenic to Likely Benign.

D. Tester, M. Ackerman, W. Zhou, 2020, Heart rhythm.

Suppression and Replacement Gene Therapy for KCNH2-Mediated Arrhythmias

Wei Zhou, D. Tester, M. Ackerman, 2022, Circulation. Genomic and precision medicine.

Cytochrome p-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels.

Hon-chi Lee, K. Dellsperger, M. Vanrollins, 2002, The Journal of pharmacology and experimental therapeutics.

Suppression-Replacement KCNQ1 Gene Therapy for Type 1 Long QT Syndrome.

D. Tester, M. Ackerman, J. Bos, 2021, Circulation.

Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring Kv4.3 Protein Inhibitor and its Contribution to Brugada Syndrome

J. Nerbonne, P. Schwartz, A. Wilde, 2014, Circulation research.

Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats.

T. Lu, T. He, Hon-chi Lee, 2008, Biophysical journal.

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141G

Christopher N. Johnson, D. Tester, M. Ackerman, 2016, Circulation. Cardiovascular genetics.

Novel mutations in the KCND3‐encoded Kv4.3 K+ channel associated with autopsy‐negative sudden unexplained death

C. Antzelevitch, D. Tester, M. Ackerman, 2012, Human mutation.

Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3-Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes

C. Antzelevitch, Wei Zhou, D. Tester, 2022, Circulation. Genomic and precision medicine.

Long QT syndrome type 5-Lite: Defining the clinical phenotype associated with the potentially proarrhythmic p.Asp85Asn-KCNE1 common genetic variant.

D. Tester, M. Ackerman, J. Bos, 2018, Heart rhythm.

Elucidation of ALG10B as a Novel Long-QT Syndrome–Susceptibility Gene

C. January, D. Tester, M. Ackerman, 2023, Circulation. Genomic and precision medicine.

CALMODULIN MUTATION (CALM1-E141G) ASSOCIATED WITH LONG QT SYNDROME DISRUPTS CALMODULIN CALCIUM BINDING AND IMPAIRS L-TYPE CA CHANNEL INACTIVATION

Christopher N. Johnson, D. Tester, M. Ackerman, 2014 .

Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms

T. Lu, Hon-chi Lee, D. Zeldin, 2006, The Journal of physiology.

Is variant pathogenicity in the eye of the beholder? A case of unexplained sudden cardiac arrest highlights the potentially dangerous role of historical rare variant compendia in SCN5A rare variant adjudication

D. Tester, M. Ackerman, J. Giudicessi, 2018, HeartRhythm case reports.

Characterization of the CACNA1C-R518C Missense Mutation in the Pathobiology of Long-QT Syndrome Using Human Induced Pluripotent Stem Cell Cardiomyocytes Shows Action Potential Prolongation and L-Type Calcium Channel Perturbation.

D. Tester, M. Ackerman, W. Zhou, 2019, Circulation. Genomic and precision medicine.

Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes

D. Tester, M. Ackerman, Wei Zhou, 2023, Stem cell reports.

Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current.

M. Ackerman, N. Boczek, Jeffrey J. Kim, 2016, International journal of cardiology.

Impaired Ca-Dependent Activation of Large-Conductance Ca-Activated K Channels in the Coronary Artery Smooth Muscle Cells of Zucker Diabetic Fatty Rats

T. Lu, T. He, Hon-chi Lee, 2008 .

Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young.

Michael J Ackerman, Dan Hu, Charles Antzelevitch, 2016, Congenital heart disease.

Identification and Functional Characterization of a Novel CACNA 1 C-Mediated Cardiac Disorder Characterized by Prolonged QT Intervals with Hypertrophic Cardiomyopathy , Congenital Heart Defects , and Sudden Cardiac

Aaron J. Johnson, D. Tester, F. Jin, 2015 .

Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign.

Jamie D. Kapplinger, D. Tester, W. Zhou, 2017, Heart rhythm.

Even pore-localizing missense variants at highly conserved sites in KCNQ1-encoded Kv7.1 channels may have wild-type function and not cause type 1 long QT syndrome: Do not rely solely on the genetic test company's interpretation

Michael T. Zimmermann, Jamie D. Kapplinger, D. Tester, 2017, HeartRhythm case reports.

SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19

Timothy J. Nelson, D. Tester, Wei Zhou, 2023, PloS one.

Enhanced Classification of Brugada Syndrome–Associated and Long-QT Syndrome–Associated Genetic Variants in the SCN5A-Encoded Nav1.5 Cardiac Sodium Channel

T. Callis, A. Wilde, Jamie D. Kapplinger, 2015, Circulation. Cardiovascular genetics.

Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome.

P. Schwartz, C. Antzelevitch, D. Tester, 2011, Heart rhythm.

Christopher N. Johnson, D. Tester, W. Chazin, 2016, Circulation. Cardiovascular genetics.

Curcumin, a Dietary Natural Supplement, Prolongs the Action Potential Duration of KCNE1-D85N Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

D. Tester, Wei Zhou, D. Ye, 2022, Heart rhythm.