Jessica Riceberg

Characterization of the Loss of SUMO Pathway Function on Cancer Cells and Tumor Proliferation

Xingyue He, J. Newcomb, J. Brownell, 2015, PloS one.

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

S. Tirrell, J. Newcomb, T. Soucy, 2018, Nature Medicine.

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.

Pooja Shah, Hua Liao, John Newcomb, 2017, Nature chemical biology.

Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.

Usha Narayanan, U. Narayanan, Peter G. Smith, 2012, Cancer cell.

A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models

Steven S. Langston, Xingyue He, E. Lightcap, 2021, Science Translational Medicine.

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.

Xingyue He, M. Mizutani, T. Soucy, 2021, Journal of medicinal chemistry.