A. Elkamhawy

发表

New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011–2021) focussing on structure–activity relationship (SAR) and docking insights

Kyeong Lee, E. M. Ali, A. Elkamhawy, 2021, Journal of enzyme inhibition and medicinal chemistry.

Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights.

M. Abdelgawad, Sami I. Alzarea, R. B. Bakr, 2020, Bioorganic & medicinal chemistry.

Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents.

A. Pae, Jung-Eun Park, Kyung-Tae Lee, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators.

W. Hur, Jung-Eun Park, Kyung-Tae Lee, 2018, European journal of medicinal chemistry.

EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.

Kyung-Tae Lee, Hwi-ho Lee, Ji-Sun Shin, 2019, Bioorganic chemistry.

Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library.

Yong Sup Lee, E. Roh, A. Hassan, 2017, Bioorganic chemistry.

ReviewEmerging Therapeutic Strategies for Parkinson's Disease and Future Prospects: A

Noha A Gouda, A. Elkamhawy, J. Cho, 2022 .

New N-Alkylated Heterocyclic Compounds as Prospective NDM1 Inhibitors: Investigation of In Vitro and In Silico Properties

M. Bellaoui, R. Touzani, F. Abrigach, 2022, Pharmaceuticals.

Suppression of Tumor Growth and Cell Migration by Indole-Based Benzenesulfonamides and Their Synergistic Effects in Combination with Doxorubicin

A. Elkamhawy, Y. Choi, Phuong Linh Nguyen, 2022, International journal of molecular sciences.

Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease.

Jiyoun Lee, A. Pae, Jung-Eun Park, 2018, European journal of medicinal chemistry.

Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.

Jiyoun Lee, A. Pae, Jung-Eun Park, 2017, European journal of medicinal chemistry.

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives

S. Son, M. El-Maghrabey, S. Ibrahim, 2022, Pharmaceuticals.

Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders.

Ashwini M. Londhe, A. Pae, Kyung-Tae Lee, 2017, European journal of medicinal chemistry.

Scaffold Repurposing Reveals New Nanomolar Phosphodiesterase Type 5 (PDE5) Inhibitors Based on Pyridopyrazinone Scaffold: Investigation of In Vitro and In Silico Properties

M. El-Maghrabey, Doaa E Abdel Rahman, Mohamed A. El Hamd, 2022, Pharmaceutics.

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations.

S. Antar, Mohamed S. Nafie, Ayman Abo Elmaaty, 2022, Journal of medicinal chemistry.

Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).

Ambily Nath Indu Viswanath, H. Seol, D. Nam, 2015, European journal of medicinal chemistry.

Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study.

Jiyoun Lee, A. Pae, E. Roh, 2014, European journal of medicinal chemistry.

Identification of novel discoidin domain receptor 1 (DDR1) inhibitors using E-pharmacophore modeling, structure-based virtual screening, molecular dynamics simulation and MM-GBSA approaches

A. Pae, Hossam Nada, A. Elkamhawy, 2022, Comput. Biol. Medicine.

Hit Identification of a Novel Quinazoline Sulfonamide as a Promising EphB3 Inhibitor: Design, Virtual Combinatorial Library, Synthesis, Biological Evaluation, and Docking Simulation Studies

Hyun-Jung Byun, Hossam Nada, Kyeong Lee, 2021, Pharmaceuticals.

Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening

E. Roh, Kyeong Lee, Usama M. Ammar, 2021, Molecules.

Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer

Hossam Nada, Kyeong Lee, A. Elkamhawy, 2021, Molecules.

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies

C. Supuran, A. Angeli, Hossam Nada, 2022, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, biological evaluation and molecular modelling of 2‐(2‐aryloxyphenyl)‐1,4‐dihydroisoquinolin‐3(2H)‐ones: A novel class of TSPO ligands modulating amyloid‐&bgr;‐induced mPTP opening

Ki Duk Park, Jiyoun Lee, Bongjin Moon, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies

Faten Farouk, Wagdy M. Eldehna, Ayman Abo Elmaaty, 2023, Journal of enzyme inhibition and medicinal chemistry.

Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling.

Dongho Lee, Chang Hoon Lee, Hossam Nada, 2022, European journal of medicinal chemistry.

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.

Jiyoun Lee, A. Pae, Jung-Eun Park, 2018, European journal of medicinal chemistry.

Emerging Therapeutic Strategies for Parkinson’s Disease and Future Prospects: A 2021 Update

Jungsook Cho, A. Elkamhawy, Noha Gouda, 2022, Biomedicines.

The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer

Hossam Nada, Kyeong Lee, A. Elkamhawy, 2021, International journal of molecular sciences.

Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies

C. Supuran, A. Angeli, Hossam Nada, 2022, International journal of molecular sciences.

Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies

A. Pae, Jung-Eun Park, T. Sim, 2016, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamides as carbonic anhydrase isoforms I and II inhibitors

C. Supuran, M. Abdelgawad, M. M. Al-Sanea, 2019, Journal of enzyme inhibition and medicinal chemistry.

Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies

E. Roh, Ahmed H. E. Hassan, E. M. Ali, 2022, Pharmaceuticals.

Development of New Meridianin/Leucettine-Derived Hybrid Small Molecules as Nanomolar Multi-Kinase Inhibitors with Antitumor Activity

E. Roh, Hossam Nada, Kyeong Lee, 2021, Biomedicines.

Targeting EGFR/HER2 tyrosine kinases with a new potent series of 6-substituted 4-anilinoquinazoline hybrids: Design, synthesis, kinase assay, cell-based assay, and molecular docking.

Ambily Nath Indu Viswanath, A. Pae, Kyung-Tae Lee, 2015, Bioorganic & medicinal chemistry letters.

Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents.

S. Paek, S. Kang, S. Oh, 2018, European journal of medicinal chemistry.

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction.

Jiyoun Lee, Bongjin Moon, A. Pae, 2017, European journal of medicinal chemistry.

Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay

T. Hadda, A. Belal, W. Mansy, 2022, Frontiers in Pharmacology.

Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress

Ki Duk Park, A. Pae, E. Roh, 2021, Antioxidants.

Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations

Hossam Nada, A. Elkamhawy, Kyeong Lee, 2022, PeerJ.

Novel Hybrid Indole-Based Caffeic Acid Amide Derivatives as Potent Free Radical Scavenging Agents: Rational Design, Synthesis, Spectroscopic Characterization, In Silico and In Vitro Investigations

A. Belal, Minkyoung Kim, A. A. Al-karmalawy, 2023, Metabolites.

Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents

Byung Sun Park, M. M. Al-Sanea, I. Kim, 2015, Molecules.

2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation

E. Roh, S. Ibrahim, Usama M. Ammar, 2022, Life.

Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress

Ki Duk Park, E. Roh, Hossam Nada, 2021, Antioxidants.

Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action.

Ki Duk Park, E. Roh, Jong-Hyun Park, 2021, Bioorganic chemistry.

Design and Synthesis of New [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Potential Antiproliferative Agents

M. M. Al-Sanea, T. Sim, E. Roh, 2015 .

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity

A. Mourad, E. Roh, A. A. Al-karmalawy, 2023, Journal of enzyme inhibition and medicinal chemistry.

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B

Ashwini M. Londhe, Ki Duk Park, A. Pae, 2020, Journal of enzyme inhibition and medicinal chemistry.

Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation.

A. Pae, Jung-Eun Park, Kyung-Tae Lee, 2019, Bioorganic chemistry.

Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines

S. Son, S. Ibrahim, A. A. Al-karmalawy, 2023, Journal of enzyme inhibition and medicinal chemistry.

Recent Developments in the Synthesis of Hybrid Heterocycles, A Promising Approach to Develop Multi-target Antibacterial Agents.

T. Farghaly, R. Mekheimer, A. Hayallah, 2023, Journal of Molecular Structure.

Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR)

Yongseok Choi, Hossam Nada, A. Elkamhawy, 2023, International journal of molecular sciences.

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

A. El-Sayed, M. M. Khalifa, A. Elkamhawy, 2023, Journal of Enzyme Inhibition and Medicinal Chemistry.

Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer—Design, Synthesis, and In Vitro Evaluation

Yongseok Choi, Sungdo Kim, Hossam Nada, 2023, ACS omega.