Mengze Zhou

发表

(E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1.

Kun Hao, Qinghua Hu, Huanqiu Li, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y14 receptor antagonists.

Kun Hao, Z. Meng, Cheng Jiang, 2019, European journal of medicinal chemistry.

HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.

Qinghua Hu, Huanqiu Li, Chunxiao Liu, 2020, International immunopharmacology.

Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Yuxin Li, Qinghua Hu, H. Ji, 2021, Frontiers in Pharmacology.

Silencing of gasdermin D by siRNA-loaded PEI-Chol lipopolymers potently relieves acute gouty arthritis through inhibiting pyroptosis.

Wenjiao Jiang, Minjie Sun, Zhanwei Zhou, 2020, Molecular pharmaceutics.

Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis

Yadong Chen, Wenjiao Jiang, Kun Hao, 2020, International journal of biological sciences.

GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

Wenjiao Jiang, Kun Hao, Sheng Tian, 2022, Frontiers in Immunology.

Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.

Eun Hee Ha, Sheng Tian, E. Ha, 2020, Bioorganic & medicinal chemistry letters.

4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3.

Qinghua Hu, Mengze Zhou, Wentao Liu, 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Discovery of a Series of 5-Amide-1H-pyrazole-3-carboxyl Derivatives as Potent P2Y14R Antagonists with Anti-Inflammatory Characters.

Z. Meng, Cheng Jiang, Li-li Xu, 2022, Journal of medicinal chemistry.

The role of P2Y6R in cardiovascular diseases and recent development of P2Y6R antagonists.

H. Ji, Qian Zhang, Qinghua Hu, 2020, Drug discovery today.

Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats.

H. Ji, Qinghua Hu, Zhonglin Yang, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

HQL6 serves as a novel P2Y14 receptor antagonist to ameliorate acute gouty arthritis through inhibiting macrophage pyroptosis.

Cheng Jiang, Zhenguo Zhang, Qinghua Hu, 2022, International immunopharmacology.

Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.

Qinghua Hu, Huanqiu Li, Mingxing Miao, 2018, Bioorganic & medicinal chemistry.

P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages

Wenjiao Jiang, Qinghua Hu, Chunxiao Liu, 2020, Cell Death & Disease.

Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.

Huan-qiu Li, G. Ao, Qinghua Hu, 2017, Bioorganic & medicinal chemistry.

Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential.

Sheng Tian, Yifan Zhu, Qinghua Hu, 2021, European journal of medicinal chemistry.

Application of Affinity-Capture Self-Interaction Nanoparticle Spectroscopy in Predicting Protein Stability, Especially for Co-Formulated Antibodies

Hao Li, Mengze Zhou, Piaoyang Sun, 2021, Pharmaceutical Research.

Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy.

Sheng Tian, Duxin Li, Yifan Zhu, 2023, Journal of medicinal chemistry.

Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y14R antagonist.

Sheng Tian, X. Zhao, Yuxin Li, 2023, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease.

Qinghua Hu, Huanqiu Li, Mengze Zhou, 2023, Journal of ethnopharmacology.

Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.

Qinghua Hu, Huanqiu Li, Mengze Zhou, 2023, European heart journal.

Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics.

Yifan Zhu, Qinghua Hu, Huanqiu Li, 2024, Journal of advanced research.

Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses

Yifan Zhu, Qinghua Hu, Huanqiu Li, 2024, Acta Pharmaceutica Sinica B.