Suguru Okuda

发表

Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli.

David J. Sherman, W. Denny, D. Kahne, 2013, Bioorganic & medicinal chemistry.

Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes

Y. Kanai, S. Nagamori, H. Tominaga, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [(18)F]FAMT positron emission tomography.

Y. Kanai, Y. Kato, K. Kaira, 2016, Journal of pharmacological sciences.

Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 Inhibitor Canagliflozin with SGLT1 and SGLT2: Inhibition Kinetics, Sidedness of Action, and Transporter-Associated Incorporation Accounting for its Pharmacodynamic and Pharmacokinetic Features

Y. Kanai, Kazunori Yamada, S. Nagamori, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

David J. Sherman, T. Silhavy, D. Kahne, 2016, Nature Reviews Microbiology.

Model of mouth-to-mouth transfer of bacterial lipoproteins through inner membrane LolC, periplasmic LolA, and outer membrane LolB

H. Tokuda, Suguru Okuda, 2009, Proceedings of the National Academy of Sciences.

Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells

Y. Kanai, Ryuichi Ohgaki, Suguru Okuda, 2022, Journal of cellular and molecular medicine.

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

O. Nureki, T. Nishizawa, Y. Kanai, 2022, Nature Communications.

Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

Y. Kanai, S. Nakagomi, M. Kanai-Azuma, 2017, Molecular and Cellular Biology.

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1).

Y. Kanai, S. Nagamori, Yoko Tanaka, 2017, Journal of pharmacological sciences.

The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.

David J. Sherman, Janine M. May, D. Kahne, 2017, Journal of the American Chemical Society.

Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor

Y. Kanai, H. Endou, Ryuichi Ohgaki, 2020, Cancer science.

Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate

Y. Teramura, Y. Kanai, M. Takai, 2017, Scientific Reports.

Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter.

H. Inohara, Y. Kanai, H. Ohki, 2019, Journal of pharmacological sciences.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

O. Nureki, T. Nishizawa, R. Ishitani, 2019, bioRxiv.

Lipoprotein sorting in bacteria.

Hajime Tokuda, Suguru Okuda, H. Tokuda, 2011, Annual review of microbiology.

Dissection of LolB function – lipoprotein binding, membrane targeting and incorporation of lipoproteins into lipid bilayers

H. Tokuda, Suguru Okuda, Shin-ichiro Narita, 2009, The FEBS journal.

Functional differentiation of structurally similar membrane subunits of the ABC transporter LolCDE complex

M. Mori, M. Mizutani, H. Tokuda, 2013, FEBS letters.

A short helix in the C‐terminal region of LolA is important for the specific membrane localization of lipoproteins

Shoji Watanabe, H. Tokuda, Suguru Okuda, 2008, FEBS Letters.

Structural Investigation of the Interaction between LolA and LolB Using NMR

I. Shimada, Hideo Takahashi, H. Tokuda, 2009, The Journal of Biological Chemistry.

Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli

D. Kahne, Elizaveta Freinkman, Suguru Okuda, 2012, Science.

Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export.

D. Kahne, N. Ruiz, Elizaveta Freinkman, 2012, Biochemistry.

Rosmarinic Acid and Sodium Citrate Have a Synergistic Bacteriostatic Effect against Vibrio Species by Inhibiting Iron Uptake

T. Fujiwara, K. Nagata, T. Asakura, 2021, International journal of molecular sciences.

Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

Y. Kanai, H. Endou, S. Nagamori, 2020, Journal of experimental & clinical cancer research : CR.

Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge

David J. Sherman, D. Needleman, D. Kahne, 2018, Science.

Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling

Y. Mori, Y. Hari, S. Nagamori, 2016, Amino Acids.

The Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

M. Nardini, M. Bolognesi, L. Gourlay, 2013, Journal of bacteriology.

Structural insights into human excitatory amino acid transporter EAAT2

O. Nureki, T. Nishizawa, Y. Kanai, 2021 .

Structurally Homologous Domains Export Is Assembled via Conserved Protein Complex for Lipopolysaccharide The Escherichia coli Lpt Transenvelope

M. Nardini, M. Bolognesi, L. Gourlay, 2013 .

Structure–activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling

Y. Mori, Y. Kanai, Y. Hari, 2016, Amino Acids.

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

M. Palacín, Y. Kanai, S. Nakagomi, 2016, Proceedings of the National Academy of Sciences.

Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate

Y. Teramura, Y. Kanai, M. Takai, 2017, Scientific Reports.

Specific transport of 3‐fluoro‐l‐α‐methyl‐tyrosine by LAT1 explains its specificity to malignant tumors in imaging

Kohei Hagiwara, Noboru Oriuchi, Yoshikatsu Kanai, 2016, Cancer science.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Takanori Nakane, Tomohiro Nishizawa, Osamu Nureki, 2019, Nature Structural & Molecular Biology.

Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge

David J. Sherman, D. Needleman, D. Kahne, 2018, Science.

Comparative genomic and transcriptomic analyses of African swine fever virus strains

Peng Lu, T. Kokuho, K. Masujin, 2023, Computational and structural biotechnology journal.

The Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

M. Nardini, M. Bolognesi, L. Gourlay, 2013, Journal of bacteriology.

Upregulation of ATF4 mediates the cellular adaptation to pharmacologic inhibition of amino acid transporter LAT1 in pancreatic ductal adenocarcinoma cells.

Ryuichi Ohgaki, Suguru Okuda, C. Jin, 2024, Journal of pharmacological sciences.

Identification of tumor-suppressive miRNAs that target amino acid transporter LAT1 and exhibit anti-proliferative effects on cholangiocarcinoma cells.

Ryuichi Ohgaki, Suguru Okuda, Hiroki Okanishi, 2024, Journal of pharmacological sciences.