T. Ishizaki

发表

Synthesis and antibacterial activity of 1-(2-fluorovinyl)-7-substituted-4-quinolone-3-carboxylic acid derivatives, conformationally restricted analogues of fleroxacin.

K. Iwase, M. Hosaka, Y. Asahina, 2005, Journal of medicinal chemistry.

Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent.

K. Iwase, M. Hosaka, Y. Asahina, 2005, Journal of medicinal chemistry.

Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) left-hand subunit

D. Boger, P. Kitos, T. Ishizaki, 1990 .

Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore

D. Boger, H. Zarrinmayeh, P. Kitos, 1990 .

New synthesis of fluoroquinolonecarboxylic acid.

T. Irikura, T. Ishizaki, S. Suzue, 1985 .

Fluorinated quinolones — new quinolone antimicrobials

S. Mitsuhashi, N. Nakanishi, S. Miyazaki, 1992 .

Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit

D. Boger, R. Wysocki, S. Munk, 1989 .

Synthesis of N-(phenylsulfonyl)-CI, N-((tert-butyloxy)carbonyl)-CI, CI-CDPI1, and CI-CDPI2: CC-1065 functional analog incorporating the parent 1,2,7,71-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunit

D. Boger, R. Wysocki, T. Ishizaki, 1990 .

Isolation and characterization of the duocarmycin-adenine DNA adduct

D. Boger, H. Zarrinmayeh, T. Ishizaki, 1991 .

(+)-CC-1065 DNA alkylation : observation of an unexpected relationship between cyclopropane electrophile reactivity and the intensity of DNA alkylation

D. Boger, S. Munk, T. Ishizaki, 1991 .

Synthesis and preliminary evaluation of (+)-CBI-indole2: an enhanced functional analog of (+)-CC-1065

D. Boger, S. Sakya, S. Munk, 1991 .

A potent, simple derivative of an analog of the CC-1065 alkylation subunit

D. Boger, H. Zarrinmayeh, P. Kitos, 1991 .

Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore

D. Boger, S. Munk, H. Zarrinmayeh, 1990 .

Synthesis and evaluation of aborted and extended CC-1065 functional analogs: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of key partial structures and definition of an additional functional role of the CC-1065 central and right-hand subunits

R. S. Coleman, D. Boger, S. Sakya, 1990 .

Resolution of a CBI precursor and incorporation into the synthesis of (+)-cbi, (+)-CBI-CDPI1, (+)-CBI-CDPI2: enhanced functional analogs of (+)-CC-1065. A critical appraisal of a proposed relationship between electrophile reactivity, DNA binding properties, and cytotoxic potency.

D. Boger, T. Ishizaki, 1990 .

Rearrangement of 4-Acetoxy-2H-1, 4-benzoxazin-3 (4H)-one

Y. Hashimoto, K. Shudo, T. Okamoto, 1983 .

Total Synthesis and Evaluation of (.+-.)-N-(tert.-Butyloxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 Functional Agents Incorporating the Equivalent 1,2,9,9a-Tetrahydrocycloprop(1,2-c)benz(1,2-e)indol-4-one (CBI) Le

D. Boger, R. Wysocki, S. Munk, 1989 .

Synthesis and antirheumatic activity of novel tetrahydro-6-quinolineacetic acid derivatives

Y. Kohno, S. Kudoh, K. Awano, 1997 .

Synthesis of N-(Phenylsulfonyl)-CI, N-((tert.-Butyloxy)carbonyl)-CI, CI-CDPI1, and CI-CDPI2: CC-1065 Functional Analogues Incorporating the Parent 1,2,7,7a-Tetrahydrocycloprop(1,2-c)indol-4-one (CI) Left-Hand Subunit.

D. Boger, R. Wysocki, T. Ishizaki, 1990 .

Duocarmycin-Pyrindamycin DNA Alkylation Properties and Identification, Synthesis, and Evaluation of Agents Incorporating the Pharmacophore of the Duocarmycin-Pyrindamycin Alkylation Subunit. Identification of the CC-1065-Duocarmycin Common Pharmacophore.

D. Boger, S. Munk, H. Zarrinmayeh, 1991 .

Synthesis and Evaluation of Aborted and Extended CC-1065 Functional Analogues: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of Key Partial Structures and Definition of an Additiona

R. S. Coleman, D. Boger, S. Sakya, 1990 .

A multi-centered electrophile formed from a unique bioactive cyclic hydroxamic acid, 4-hydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one

Y. Hashimoto, K. Shudo, T. Ishizaki, 1991 .