P. Hylemon

发表

Cardiovascular , Pulmonary , and Renal Pathology Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice

K. Boini, Pin-Lan Li, M. Xia, 2011 .

17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines

P. Dent, A. Yacoub, S. Grant, 2007, Molecular Cancer Therapeutics.

Microbial Functional Change is Linked with Clinical Outcomes after Capsular Fecal Transplant in Cirrhosis.

S. Taylor-Robinson, Roger Williams, I. Cox, 2019, JCI insight.

Cyclic adenosine 3',5'-monophosphate levels and activities of adenylate cyclase and cyclic adenosine 3',5'-monophosphate phosphodiesterase in Pseudomonas and Bacteroides

P. Phibbs, L. S. Siegel, P. Hylemon, 1977, Journal of bacteriology.

Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis*

P. Fisher, G. Sundaresan, M. Subler, 2015, The Journal of Biological Chemistry.

Biotransformation of 16 alpha-hydroxyprogesterone by Eubacterium sp. 144: non-enzymatic addition of L-cysteine to delta 16-progesterone.

V. Bokkenheuser, J. Winter, T. L. Glass, 1982, Journal of lipid research.

A potential role for resistant starch fermentation in modulating colonic bacterial metabolism and colon cancer risk

J. Ridlon, Jason M. Ridlon, P. Hylemon, 2006, Cancer biology & therapy.

Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via Gαi Signaling

P. Dent, S. Grant, W. Pandak, 2007, Molecular Pharmacology.

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes

S. Spiegel, P. Dent, Clint Mitchell, 2005, Hepatology.

A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes.

C. Benz, P. Dent, J. Park, 2000, Molecular biology of the cell.

Positive and negative regulation of JNK1 by protein kinase C and p42MAP kinase in adult rat hepatocytes

P. Dent, R. Mikkelsen, S. Grant, 1997 .

Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rat

D. Heuman, Z. Vlahcevic, P. Hylemon, 1988, Hepatology.

Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria Published, JLR Papers in Press, April 12, 2006.

Xiaobo Li, S. Ren, W. Pandak, 2006, Journal of Lipid Research.

Mechanism of intestinal formation of deoxycholic acid from cholic acid in humans: evidence for a 3-oxo-delta 4-steroid intermediate.

K. Einarsson, P. Melone, I. Björkhem, 1989, Journal of lipid research.

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes

W. Pandak, D. Heuman, Z. Vlahcevic, 1991, Hepatology.

Mechanism of intestinal 7 alpha-dehydroxylation of cholic acid: evidence that allo-deoxycholic acid is an inducible side-product.

P. Melone, I. Björkhem, E. Lund, 1991, Journal of lipid research.

Purification and characterization of a microbial, NADP-dependent bile acid 7 alpha-hydroxysteroid dehydrogenase.

P. de Prada, C. Franklund, P. Hylemon, 1990, The Journal of biological chemistry.

Purification and characterization of bile salt hydrolase from Clostridium perfringens.

P. Hylemon, R. Gopal‐Srivastava, R. Gopal‐srivastava, 1988, Journal of lipid research.

Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling*

P. Fisher, P. Dent, S. Grant, 2008, Journal of Biological Chemistry.

Purification and characterization of a novel 17 alpha-hydroxysteroid dehydrogenase from an intestinal Eubacterium sp. VPI 12708.

K. Setchell, P. de Prada, P. Hylemon, 1994, Journal of lipid research.

Cofactor requirements of steroid-17-20-desmolase and 20 alpha-hydroxysteroid dehydrogenase activities in cell extracts of Clostridium scindens.

V. Bokkenheuser, J. Winter, P. Hylemon, 1987, Journal of steroid biochemistry.

Mode of action of steroid desmolase and reductases synthesized by Clostridium "scindens" (formerly Clostridium strain 19).

E. Mosbach, V. Bokkenheuser, J. Winter, 1984, Journal of lipid research.

16α-Dehydration of corticoids by bacteria isolated from rat fecal flora

V. Bokkenheuser, J. Winter, S. O'Rourke, 1982 .

Characterization of a corticosteroid 21-dehydroxylase from the intestinal anaerobic bacterium, Eubacterium lentum.

S. Feighner, P. Hylemon, 1980, Journal of lipid research.

Characterization of a C21 neutral steroid hormone transforming enzyme, 21-dehydroxylase, in crude cell extracts of Eubacterium lentum.

S. Feighner, V. Bokkenheuser, J. Winter, 1979, Biochimica et biophysica acta.

Evidence against the presence of cyclic AMP and related enzymes in selected strains of Bacteroides fragilis.

P. Phibbs, P. Hylemon, 1974, Biochemical and biophysical research communications.

Fas Ligand-dependent and -independent mechanisms of toxicity induced by T cell lymphomas in lymphoid organs and in the liver.

M. Nagarkatti, P. Nagarkatti, C. Lombard, 2003, Clinical immunology.

A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy

S. Taylor-Robinson, P. Fatouros, C. Schubert, 2012, Metabolic Brain Disease.

Independent regulation of hexose catabolizing enzymes and glucose transport activity in Pseudomonas aeruginosa.

P. Phibbs, P. Hylemon, 1972, Biochemical and biophysical research communications.

Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3

P. Fisher, P. Dent, S. Grant, 2003, Journal of gastroenterology and hepatology.

Altered levels of phosphoinositide metabolites and activation of guanine‐nucleotide dependent phospholipase C in rat hepatic tumors

S. Strom, N. Lalwani, P. Hylemon, 1991, Journal of cellular physiology.

Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

P. Dent, K. Valerie, G. Amorino, 2003, Molecular and Cellular Biology.

Transport and Catabolism of d-Fructose by Spirillum itersonii

N. Krieg, P. Phibbs, P. Hylemon, 1974, Journal of bacteriology.

Hepatitis B virus X protein increases expression of p21Cip‐1/WAF1/MDA6 and p27Kip‐1 in primary mouse hepatocytes, leading to reduced cell cycle progression

P. Fisher, P. Dent, A. Yacoub, 2001 .

The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular Mechanisms and Clinical Implications

R. Parker, K. Yarasheski, O. Flint, 2009, Toxicologic pathology.

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

P. Fisher, S. Spiegel, K. Ryan, 2008, Cancer biology & therapy.

Cholesterol and bile acid metabolism in cultures of primary rat bile ductular epithelial cells

D. Heuman, A. Sirica, Z. Vlahcevic, 1990, Hepatology.

Cyclin kinase inhibitor p21 potentiates bile acid–induced apoptosis in hepatocytes that is dependent on p53

P. Fisher, P. Dent, S. Grant, 2002, Hepatology.

Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.

J. Grandis, P. Dent, A. Yacoub, 2005, Biochemical pharmacology.

Apoptotic Response of Hepatocytes-Terminal Kinase Pathways , Modulates the 2 Signal-Regulated Kinase and c-Jun NH c-Jun Function , via the Extracellular , CREB , and β Bile Acid Regulation of C / EBP

P. Dent, K. Valerie, G. Amorino, 2003 .

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

P. Fisher, P. Nagarkatti, R. Schmidt-Ullrich, 2001, Molecular biology of the cell.

Highly Active Antiretroviral Therapy (HAART) and Metabolic Complications

W. Pandak, Huiping Zhou, B. Zha, 2011 .

Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes

P. Dent, S. Grant, Weiqun Li, 2004, Hepatology.

Regulation of autophagy by ceramide-CD95-PERK signaling

P. Fisher, P. Dent, S. Grant, 2008, Autophagy.

Inhibition of the MAPK and PI3K pathways enhances UDCA‐induced apoptosis in primary rodent hepatocytes

P. Dent, A. Yacoub, S. Grant, 2002, Hepatology.

Approaches for monitoring signal transduction changes in normal and cancer cells.

P. Fisher, P. Dent, S. Grant, 2007, Methods in molecular biology.

Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short‐term biliary diversion in the rat

P. Hylemon, W. Pandak, D. Heuman, 1993, Hepatology.

Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in lymph-fistula rats: evidence for both transcriptional and post-transcriptional mechanisms for down-regulation of the two enzymes by bile acids.

I. Björkhem, G. Eggertsen, U. Andersson, 1993, Journal of lipid research.

Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression.

P. Dent, J. Park, A. Yacoub, 2001, Hepatology.

Dehydroxylation of 1 G ~ hydroxyprogesterone by fecal flora of man and rat

E. Mosbach, V. Bokkenheuser, J. Winter, 2002 .

Dehydroxylation of 16 alpha-hydroxyprogesterone by fecal flora of man and rat.

E. Mosbach, V. Bokkenheuser, J. Winter, 1981, Journal of lipid research.

A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy

S. Taylor-Robinson, P. Fatouros, C. Schubert, 2012, Metabolic Brain Disease.

Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708

P. Hylemon, W. White, D. Mallonee, 1990, Journal of bacteriology.

Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat.

P. Hylemon, W. Pandak, D. Heuman, 1991, Gastroenterology.

The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase

J. Adams, P. Hylemon, D. Mallonee, 1992, Journal of bacteriology.

Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat.

P. Hylemon, J. Chiang, W. Pandak, 1991, The Journal of biological chemistry.

Effects of different bile salts on steady‐state mRNA levels and transcriptional activity of cholesterol 7α‐hydroxylase

J. Chiang, K. Redford, W. Pandak, 1994 .

Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short‐term biliary diversion in the rat

W. Pandak, D. Heuman, Z. Vlahcevic, 1993, Hepatology.

Highly Active Antiretroviral Therapy (HAART) and Metabolic Complications

W. Pandak, Huiping Zhou, B. Zha, 2011 .