Zheng Li

发表

Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome.

Luyong Zhang, Jing Han, Zheng Li, 2021, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.

Luyong Zhang, Lian Chen, Zheng Li, 2022, Bioorganic & medicinal chemistry.

HWL‐088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice

Luyong Zhang, Zheng Li, Q. Ren, 2020, British journal of pharmacology.

ZLY032, the first-in-class dual FFA1/PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosis.

Luyong Zhang, Zheng Li, Q. Ren, 2020, Pharmacological research.

A novel FFA1 agonist, CPU025, improves glucose-lipid metabolism and alleviates fatty liver in obese-diabetic (ob/ob) mice.

Hai Qian, Chunxiao Liu, Zheng Li, 2020, Pharmacological research.

Design, synthesis, and biological evaluation of novel dual PPARα/δ agonists for the treatment of T2DM.

Zheng Li, Q. Ren, Zongtao Zhou, 2020, Bioorganic chemistry.

Design, synthesis and biological activity of deuterium-based FFA1 agonists with improved pharmacokinetic profiles.

Luyong Zhang, Bing Liu, Zheng Li, 2019, Bioorganic & medicinal chemistry letters.

Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents.

Luyong Zhang, Bing Liu, Zheng Li, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPARγ and PPARδ.

Luyong Zhang, Zheng Li, Zongtao Zhou, 2018, European journal of medicinal chemistry.

Structure-based design of free fatty acid receptor 1 agonists bearing non-biphenyl scaffold.

Hai Qian, Hongwei Jiang, Luyong Zhang, 2018, Bioorganic chemistry.

Nitric oxide donor-based FFA1 agonists: Design, synthesis and biological evaluation as potential anti-diabetic and anti-thrombotic agents.

Luyong Zhang, Zheng Li, Xiao-Tong Zeng, 2018, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of deuterated phenylpropionic acid derivatives as potent and long-acting free fatty acid receptor 1 agonists.

Wen-long Huang, Hai Qian, W. Shi, 2018, Bioorganic chemistry.

Design, synthesis and biological evaluation of nitric oxide releasing derivatives of dapagliflozin as potential anti-diabetic and anti-thrombotic agents.

Luyong Zhang, Zheng Li, Liming Deng, 2018, Bioorganic & medicinal chemistry.

Improving metabolic stability with deuterium: The discovery of GPU-028, a potent free fatty acid receptor 4 agonists.

Xiaoting Fu, Jing Han, Mingyang Wang, 2017, Bioorganic & medicinal chemistry.

Design, synthesis and structure-activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker.

Wen-long Huang, Hai Qian, W. Shi, 2017, Bioorganic & medicinal chemistry.

Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease.

Zheng Li, Q. Ren, Zongtao Zhou, 2020, Bioorganic chemistry.

Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents.

Luyong Zhang, Zheng Li, Q. Ren, 2021, European journal of medicinal chemistry.

HWL‐088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis

Guangji Wang, Zheng Li, Q. Ren, 2020, The Journal of pharmacy and pharmacology.

Discovery of a structurally novel, potent, and once-weekly free fatty acid receptor 1 agonist for the treatment of diabetes.

Luyong Zhang, Zhongcheng Yang, Zheng Li, 2022, European journal of medicinal chemistry.

Improving metabolic stability with deuterium: The discovery of HWL‐066, a potent and long‐acting free fatty acid receptor 1 agonists

Wen-long Huang, Hai Qian, W. Shi, 2018, Chemical biology & drug design.

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Wen-long Huang, Hai Qian, W. Shi, 2016, Bioorganic & medicinal chemistry.

Current status of GPR40/FFAR1 modulators in medicinal chemistry (2016–2019): a patent review

Luyong Zhang, Zheng Li, Zongtao Zhou, 2019, Expert opinion on therapeutic patents.

Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance.

Wen-long Huang, Hai Qian, B. Zhang, 2017, Journal of medicinal chemistry.

Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.

Wen-long Huang, Hai Qian, B. Zhang, 2017, Journal of medicinal chemistry.

Novel coumarin modified GLP‐1 derivatives with enhanced plasma stability and prolonged in vivo glucose‐lowering ability

Wen-long Huang, Hai Qian, Chenyu Zhang, 2014, British journal of pharmacology.

Design, synthesis, and biological activity of novel dicoumarol glucagon-like peptide 1 conjugates.

Wen-long Huang, Hai Qian, Xiao-yun Zhu, 2013, Journal of medicinal chemistry.

Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors.

Jing Li, Lei Zhang, Zheng Li, 2017, European journal of medicinal chemistry.

Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.

Zheng Li, Yueming Chen, Liming Deng, 2019, Bioorganic & medicinal chemistry letters.

Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Wen-long Huang, Hai Qian, Miaobo Pan, 2015, European journal of medicinal chemistry.

Hepatoprotective effects of ZLY16, a dual peroxisome proliferator-activated receptor α/δ agonist, in rodent model of nonalcoholic steatohepatitis.

Luyong Zhang, Zheng Li, Q. Ren, 2020, European journal of pharmacology.

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Wen-long Huang, Hai Qian, Baowei Yang, 2015, Bioorganic & medicinal chemistry.

Design, Synthesis and in vivo Evaluation of Novel C‐Aryl Glucosides as Potent Sodium‐Dependent Glucose Cotransporters Inhibitors for the Treatment of Diabetes

Wen-long Huang, Hai Qian, Qianqian Qiu, 2015, Chemical biology & drug design.

Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents.

Luyong Zhang, Zheng Li, Zongtao Zhou, 2019, Bioorganic chemistry.

Advances in computer-aided drug design for type 2 diabetes

Luyong Zhang, Zheng Li, Wanqiu Huang, 2022, Expert opinion on drug discovery.

Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development

Wen-long Huang, Hai Qian, Qianqian Qiu, 2016, Expert opinion on investigational drugs.

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Wen-long Huang, Hai Qian, W. Shi, 2017, European journal of medicinal chemistry.

C‐Aryl Glucosides with Substituents at the Distal Aryl Ring as Sodium‐Dependent Glucose Cotransporter Inhibitors for the Treatment of Diabetes Mellitus

Wen-long Huang, Hai Qian, Baowei Yang, 2015, Chemical biology & drug design.

Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges

Wen-long Huang, Hai Qian, Zheng Li, 2018, Medicinal research reviews.

Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease.

Luyong Zhang, Zhongcheng Yang, Zheng Li, 2023, Journal of medicinal chemistry.

Novel fatty chain-modified glucagon-like peptide-1 conjugates with enhanced stability and prolonged in vivo activity.

Wen-long Huang, Hai Qian, Xun Huang, 2013, Biochemical pharmacology.

Discovery of a novel and orally active Farnesoid X receptor agonist for the protection of acetaminophen‐induced hepatotoxicity

Guangji Wang, Zheng Li, Q. Ren, 2021, Chemical biology & drug design.

Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.

Qianqian Qiu, Zheng Li, Q. Ren, 2019, Bioorganic chemistry.

Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold.

Wen-long Huang, Hai Qian, Chunxiao Liu, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists.

Luyong Zhang, D. Zhou, Zhongcheng Yang, 2023, European journal of medicinal chemistry.

Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist.

Zheng Li, Q. Ren, Zongtao Zhou, 2020, European journal of medicinal chemistry.

Discovery of a novel oxime ether scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists

Wen-long Huang, Hai Qian, Zheng Li, 2016 .

Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis.

Luyong Zhang, Zhongcheng Yang, Zheng Li, 2023, Biochemical pharmacology.

Structure-based optimization of free fatty acid receptor 1 agonists bearing thiazole scaffold.

Hongwei Jiang, Luyong Zhang, J. Hou, 2018, Bioorganic chemistry.

Identification of highly potent and orally available free fatty acid receptor 1 agonists bearing isoxazole scaffold.

Wen-long Huang, Hai Qian, W. Shi, 2017, Bioorganic & medicinal chemistry.

Discovery of novel free fatty acid receptor 1 agonists bearing triazole core via click chemistry.

Wen-long Huang, Hai Qian, Huilan Li, 2016, Bioorganic & medicinal chemistry.

Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Wen-long Huang, Hai Qian, W. Shi, 2016, Bioorganic & medicinal chemistry.

Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Wen-long Huang, Hai Qian, Zheng Li, 2015, Bioorganic & medicinal chemistry.