Joshua Close

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).

Joshua Close, Sriram Tyagarajan, C. Kenific, 2008, Bioorganic & medicinal chemistry letters.

Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).

J. Grimm, Melissa Chenard, A. Kral, 2009, Bioorganic & medicinal chemistry letters.

Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.

I. Kariv, C. Moxham, Thomas A. Miller, 2012, Bioorganic & medicinal chemistry letters.

Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.

Matthew L. Maddess, Y. Liu, X. Fradera, 2022, ACS medicinal chemistry letters.

The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.

Duan Liu, J. Klappenbach, X. Fradera, 2017, Journal of medicinal chemistry.

Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors.

A. Kral, B. Haines, Thomas A. Miller, 2014, Biochemistry.