John J. Wright

发表

Retuning the Catalytic Bias and Overpotential of a [NiFe]-Hydrogenase via a Single Amino Acid Exchange at the Electron Entry/Exit Site

A. Bond, D. Gavaghan, A. Parkin, 2017, Journal of the American Chemical Society.

Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System

J. Hirst, H. R. Bridges, N. Burger, 2022, Journal of the American Chemical Society.

Structure of inhibitor-bound mammalian complex I

Ville R. I. Kaila, J. Hirst, Maxie M. Roessler, 2020, Nature Communications.

Semisynthetic aminoglycoside antibacterials. Part 11. Solution conformations of semisynthetic and naturally occurring aminoglycoside antibiotics

P. Reichert, A. Mallams, J. Morton, 1981 .

HMG-CoA reductase inhibitors 4. Tetrazole series: conformational constraints and structural requirements at the hydrophobic domain.

R. Parker, J. BrownPeter, John J. Wright, 1992 .

Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy

Caroline S. Pereira, J. Hirst, G. M. Arantes, 2022, Nature Communications.

Using a chimeric respiratory chain and EPR spectroscopy to determine the origin of semiquinone species previously assigned to mitochondrial complex I

J. Hirst, Maxie M. Roessler, Justin G Fedor, 2020, BMC Biology.

Using Hyperfine Electron Paramagnetic Resonance Spectroscopy to Define the Proton-Coupled Electron Transfer Reaction at Fe-S Cluster N2 in Respiratory Complex I.

J. Hirst, E. Salvadori, Maxie M. Roessler, 2017, Journal of the American Chemical Society.

Making the leap from structure to mechanism: are the open states of mammalian complex I identified by cryoEM resting states or catalytic intermediates?

J. Hirst, D. Grba, John J. Wright, 2022, Current opinion in structural biology.

Paracoccus denitrificans: a genetically tractable model system for studying respiratory complex I

J. Hirst, John J. Wright, O. Biner, 2021, Scientific Reports.

A novel synthesis of cis-1-[[6-chloro-3-[(2-chloro-3-thienyl)methoxy]-2,3-dihydrobenzo[b]thien-2-yl]methyl]1h-imidazole : A new class of azole antifungal agents

A. McPhail, M. Puar, John J. Wright, 1988 .

Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.

D. Langley, C. Fairchild, R. Kramer, 2005, Journal of medicinal chemistry.

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activit

C. Fairchild, M. Deshpande, R. Kramer, 2004 .

A Novel Synthesis of cis-1-((6-Chloro-3-((2-chloro-3-thienyl)methoxy)-2,3-dihydrobenzo(b)thien-2-yl)methyl)-1H-imidazole: A New Class of Azole Antifungal Agents.

A. McPhail, M. Puar, John J. Wright, 1988 .

Interaction of vicinal and nonvicinal amino-hydroxy group pairs in aminoglycoside-aminocyclitol antibiotics with transition metal cations. Selective N protection

W. N. Turner, P. Reichert, A. Cooper, 1978 .

Small-volume potentiometric titrations: EPR investigations of Fe-S cluster N2 in mitochondrial complex I.

J. Hirst, E. Salvadori, Maxie M. Roessler, 2016, Journal of inorganic biochemistry.

Synthesis and Antifungal Properties of 14-Aminomethyl-Substituted Lanosterol Derivatives.

D. Loebenberg, D. Feingold, A. Cooper, 1989 .

Synthesis of garosamine and of related amino sugars. An efficient tetrahydrooxazine ring opening

John J. Wright, Charles L. Luce, 1978 .

Synthesis of 3-amino-2,3-dideoxy-α-D-arabino-hexopyranosyl gentamine C1

A. Mallams, P. Daniels, John J. Wright, 1973 .

Interaction of vicinal and nonvicinal amino-hydroxy group pairs in aminoglycoside-aminocyclitol antibiotics with transition metal cations. Selective N protection

W. N. Turner, P. Reichert, A. Cooper, 1978 .

SYNTHESIS OF 3-AMINO-2,3-DIDEOXY-ALPHA-D-ARABINO-HEXOPYRANOSYL GENTAMINE C1

A. Mallams, P. Daniels, John J. Wright, 1973 .

Using a chimeric respiratory chain and EPR spectroscopy to determine the origin of semiquinone species previously assigned to mitochondrial complex I

J. Hirst, Maxie M. Roessler, John J. Wright, 2020, BMC Biology.

A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I

J. Hirst, Maxie M. Roessler, K. Richardson, 2021, The Journal of biological chemistry.

Synthesis of 14-α-aminomethyl substituted lanosterol derivatives; inhibitors of fungal ergosterol biosynthesis

D. Loebenberg, D. Feingold, A. Cooper, 1989 .

Functional basis of electron transport within photosynthetic complex I

M. Hippler, W. Myers, M. Šimėnas, 2021, Nature Communications.

EV-22, a novel antifungal triacetylenic dioxolone

B. Pramanik, M. Puar, John J. Wright, 1988 .

Re-engineering a NiFe hydrogenase to increase the H2 production bias while maintaining native levels of O2 tolerance

A. Parkin, Maxie M. Roessler, J. Moir, 2016, Chemical communications.

Cryo-EM structures reveal ubiquinone-10 binding to mitochondrial complex I and conformational transitions associated with Q-site occupancy

Caroline S. Pereira, J. Hirst, G. M. Arantes, 2022, bioRxiv.

Inhibitors of Blood Platelet cAMP Phosphodiesterase. Part 4. Structural Variation of the Side-Chain Terminus of Water-Soluble 1,3- Dihydro-2H-imidazo(4,5-b)quinolin-2-one Derivatives.

N. Meanwell, J. A. Thomas, J. Russell, 1994 .

3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase: Molecular Modeling, Three-Dimensional Structure-Activity Relationships, Inhibitor Design

W. Harte, I. Motoc, John J. Wright, 1991 .

Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells.

H. Mitsuya, J. Wright, K. Gunter, 1990, Science.

1,3-Dihydro-2H-imidazo(4,5-b)quinolin-2-ones. Inhibitors of Blood Platelet cAMP Phosphodiesterase and Induced Aggregation.

N. Meanwell, E. C. Smith, John J. Wright, 1992 .

3-Hydroxy-3-methylglutaryl-coenzyme a reductase: Three-dimensional structure-activity relationships and inhibitor design

W. Harte, I. Motoc, John J. Wright, 1990 .