T. Higashino

发表

Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12

N. Shinomiya, K. Takeuchi, I. Inoue, 2021, Rheumatology.

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

Y. Kamatani, Y. Okada, T. Merriman, 2016, Annals of the rheumatic diseases.

A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility

Y. Okada, N. Shinomiya, A. Hishida, 2017, Human Cell.

Expression of a human NPT1/SLC17A1 missense variant which increases urate export

N. Shinomiya, Y. Kanai, S. Nagamori, 2016, Nucleosides, nucleotides & nucleic acids.

A new approach to identifying hypertension-associated genes in the mesenteric artery of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

H. Okamura, Naohisa Goto, D. Okuzaki, 2019, Journal of hypertension.

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression

N. Shinomiya, S. Fujimori, T. Takada, 2018, Scientific Reports.

Assessment of Delayed Large Local Reactions After the First Dose of the SARS-CoV-2 mRNA-1273 Vaccine in Japan.

Shuichi Kawano, T. Higashino, Yuki Yamazaki, 2022, JAMA dermatology.

Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2

K. Wakai, N. Shinomiya, M. Kawaguchi, 2016, Scientific Reports.

Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method.

Y. Aragane, H. Higashino, T. Higashino, 2022, Frontiers in bioscience.

Thromboxane A2 Receptor Antagonist (ONO-8809) Attenuates the Renal Disorders Caused by Salt-Overload in Stroke-Prone Spontaneously Hypertensive Rats

Y. Nagatani, H. Higashino, T. Higashino, 2021 .

Porphyrin accumulation in humans with common dysfunctional variants of ABCG2, a porphyrin transporter: potential association with acquired photosensitivity

N. Shinomiya, T. Satoh, A. Nakayama, 2021, Human Cell.

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Y. Kamatani, Y. Okada, T. Merriman, 2019, Annals of the rheumatic diseases.

Two cases of erythema exsudativum multiforme associated with Chlamydia pneumoniae infection

Takashi Kobayashi, S. Tajima, K. Ono, 2012, The Journal of dermatology.

Genotype–phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis

M. Simpson, J. Uitto, J. McGrath, 2019, The British journal of dermatology.

Advances in the genetic understanding of hypohidrotic ectodermal dysplasia

J. McGrath, T. Higashino, J. Y. Lee, 2017 .

Multiple common and rare variants of ABCG2 cause gout

T. Merriman, K. Wakai, N. Shinomiya, 2017, RMD Open.

Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese

K. Wakai, N. Shinomiya, Y. Sakurai, 2018, BMC Medical Genetics.

Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk

N. Shinomiya, Y. Sakurai, M. Naito, 2017, Scientific Reports.

Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach

N. Shinomiya, R. Okada, A. Hishida, 2021, Human Cell.

Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families

N. Shinomiya, R. Fujimaru, T. Takada, 2020, Rheumatology.

The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression

N. Shinomiya, Y. Sakurai, A. Hishida, 2016, Scientific Reports.

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression

N. Shinomiya, S. Fujimori, T. Takada, 2018, Scientific Reports.

Practical forensic use of kinship determination using high-density SNP profiling based on a microarray platform, focusing on low-quantity DNA.

A. Fujimoto, K. Tokunaga, A. Mabuchi, 2022, Forensic science international. Genetics.

A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population

Y. Kamatani, N. Shinomiya, A. Hishida, 2020, Human Cell.

Meta-analysis confirms an association between gout and a common variant of LRRC16A locus

N. Shinomiya, M. Naito, M. Kawaguchi, 2017, Modern rheumatology.

Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population.

N. Shinomiya, M. Naito, S. Kawai, 2016, Drug metabolism and pharmacokinetics.

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients

Y. Kamatani, Y. Okada, T. Merriman, 2020, Annals of the Rheumatic Diseases.

Thromboxane A2 receptor antagonist (ONO‐8809) attenuates renal disorders caused by salt overload in stroke‐prone spontaneously hypertensive rats

Y. Nagatani, H. Higashino, T. Higashino, 2021, Clinical and experimental pharmacology & physiology.

Germline mutation in PDGFRB may be implicated in hereditary progressive mucinous histiocytosis.

M. Simpson, J. McGrath, J. Demoulin, 2020, The British journal of dermatology.

A germline mutation in the platelet‐derived growth factor receptor beta gene may be implicated in hereditary progressive mucinous histiocytosis

M. Simpson, J. McGrath, J. Demoulin, 2021 .

Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels

N. Osada, N. Shinomiya, T. Tamura, 2019, Annals of the rheumatic diseases.

Photolocalized varicella in an adult

T. Higashino, M. Sakiyama, H. Maeshima, 2014, The British journal of dermatology.