K. Pickup

发表

Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor

P. Ballard, P. Dickinson, M. Cantarini, 2016, Drug Metabolism and Disposition.

Title Page Metabolic Disposition of Osimertinib in Rat , Dog , and Man : insights into a drug designed to bind covalently to a cysteine residue of EGFR

P. Ballard, P. Dickinson, M. Cantarini, 2016 .

Different inhibition and induction profiles of hepatic drug metabolism in rats and dogs by two structurally related pyridyl diazinone cardiotonic agents.

D. Mckillop, K. Pickup, 1991, Biochemical pharmacology.

A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.

I. Wilson, M. Hutchison, R. Gallagher, 2014, Biochemical pharmacology.

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

I. Wilson, M. Hutchison, J. Swales, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Diclofenac metabolism in the mouse: Novel in vivo metabolites identified by high performance liquid chromatography coupled to linear ion trap mass spectrometry

I. Wilson, S. Sarda, T. Schulz-utermoehl, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

The metabolic disposition of an orally active pyridyl thiadiazinone cardiotonic agent (MPTD) in rat and baboon.

D. Mckillop, K. Pickup, A. Swaisland, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice

I. Wilson, S. Sarda, H. Jones, 2016, Archives of Toxicology.

The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse

I. Wilson, S. Sarda, H. Jones, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice

I. Wilson, S. Sarda, J. Foster, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Drug-drug interactions and metabolism in cytochrome P450 2C knockout mice: application to troleandomycin and midazolam.

I. Wilson, M. Hutchison, R. Gallagher, 2013, Biochemical pharmacology.

In vitro metabolism of gefitinib in human liver microsomes

G. S. Miles, M. Hutchison, N. Bushby, 2004, Xenobiotica; the fate of foreign compounds in biological systems.

Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity

Matthew Grist, P. Jänne, K. Varnäs, 2016, Clinical Cancer Research.

Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism

I. Wilson, D. Weston, G. V. Van Berkel, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: Application to the metabolism of diclofenac

I. Wilson, S. Sarda, E. Karlsson, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

HPLC–MS Profiling and Structural Identification of [14C]-Diclofenac Metabolites in Mouse Bile

I. Wilson, S. Sarda, K. Pickup, 2014, Chromatographia.