Takao Uno

TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations

R. Wadhwa, Shinichi Hasako, Y. Aoyagi, 2018, Molecular Cancer Therapeutics.

TAS6417, a novel epidermal growth factor receptor inhibitor targeting exon 20 insertion mutations

R. Wadhwa, Shinichi Hasako, Y. Aoyagi, 2018 .

Stereoselective total synthesis of ent-EI-1941-2 and Epi-ent-EI-1941-2.

Y. Hayashi, M. Shoji, Takao Uno, 2004, Organic letters.

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2005, Angewandte Chemie.

Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives.

H. Kakeya, H. Osada, R. Onose, 2005, The Journal of organic chemistry.

Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2004, Bioorganic & medicinal chemistry letters.

Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.

K. T. Chong, Tatsuya Suzuki, S. Ohkubo, 2018, Journal of medicinal chemistry.

Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.

K. Tsumoto, S. Nagatoishi, S. Ohkubo, 2021, Journal of medicinal chemistry.