Jonathan P. Orme

发表

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

J. Riess, D. Gandara, J. Keck, 2018, Molecular Cancer Therapeutics.

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.

Paul D. Smith, Michal Bista, D. Hargreaves, 2021, Journal of medicinal chemistry.

Osimertinib, an Irreversible Next-Generation EGFR Tyrosine Kinase Inhibitor, Exerts Antitumor Activity in Various Preclinical NSCLC Models Harboring the Uncommon EGFR Mutations G719X or L861Q or S768I

Paul D. Smith, B. Cho, Matthew J. Martin, 2020, Molecular Cancer Therapeutics.

An automated cell line authentication method for AstraZeneca global cell bank using deep neural networks on brightfield images

A. Corrigan, Yinhai Wang, Lei Tong, 2021, Scientific Reports.

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

I. Barrett, K. Varnäs, K. Valerie, 2018, Science Advances.

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Fiona Pachl, A. Pike, M. O’Connor, 2021, Journal of medicinal chemistry.

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1

Paul Hemsley, Joseph Shaw, Ian Dale, 2018, SLAS discovery : advancing life sciences R & D.

Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation.

E. Hennessy, C. Chuaqui, J. Debreczeni, 2016, ACS medicinal chemistry letters.

Abstract LB-273: A head-to-head comparison of the properties of five clinical PARP inhibitors identifies new insights that can explain both the observed clinical efficacy and safety profiles

Fiona Pachl, M. O’Connor, Glen Hawthorne, 2018, Experimental and Molecular Therapeutics.

Cellular Assay Optimization

David I. Fisher, K. Roberts, Jonathan P. Orme, 2011, Journal of biomolecular screening.