R. Qu

发表

Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors

Honglin Li, Jiankun Lyu, Zhenjiang Zhao, 2017, Scientific Reports.

Identification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin

Yi Chen, Jian Ding, Lin-jiang Tong, 2014, Acta Pharmacologica Sinica.

Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation.

Yi Chen, Jian Ding, Lin-jiang Tong, 2018, European journal of medicinal chemistry.

2,4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR(L⁸⁵⁸R/T⁷⁹⁰M).

J. Smaill, Jian Ding, Lin-jiang Tong, 2015, Bioorganic & medicinal chemistry letters.

Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC.

Jian Ding, Lin-jiang Tong, G. Liang, 2017, European journal of medicinal chemistry.

Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors

Honglin Li, Jiankun Lyu, Zhenjiang Zhao, 2017, Scientific Reports.

Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.

Jian Li, Xun Ji, Hualiang Jiang, 2014, Bioorganic & medicinal chemistry.

Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.

Wei Zhang, Jian Ding, Lin-jiang Tong, 2016, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Honglin Li, Jiankun Lyu, Zhenjiang Zhao, 2018, Journal of medicinal chemistry.

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Yi Chen, Jian Ding, Lin-jiang Tong, 2020, Molecular Cancer.

DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo

Yi Chen, Jian Ding, Lin-jiang Tong, 2016, Acta Pharmacologica Sinica.

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Yi Chen, Jian Ding, Lin-jiang Tong, 2020, Molecular Cancer.