Jianliang Shi

发表

Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481

J. Macor, A. Mathur, M. Ahlijanian, 2019, ACS medicinal chemistry letters.

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

A. Good, J. Macor, J. Marcinkeviciene, 2011, Bioorganic & medicinal chemistry letters.

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.

J. Macor, A. Mathur, B. Srikumar, 2018, ACS medicinal chemistry letters.

Design and optimization of tricyclic gamma-secretase modulators.

J. Macor, R. Olson, J. Toyn, 2016, Bioorganic & medicinal chemistry letters.

Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.

J. Macor, H. Lewis, Chiehying Y Chang, 2016, Journal of medicinal chemistry.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

J. Macor, M. Ahlijanian, Joseph L. Cantone, 2014, International journal of Alzheimer's disease.

Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors

Michael G. Yang, R. Olson, D. Robertson, 2007 .

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).

A. Good, J. Macor, J. Marcinkeviciene, 2011, Bioorganic & medicinal chemistry letters.

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Andrea Mcclure, J. Macor, H. Lewis, 2016, ACS medicinal chemistry letters.

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.

N. Meanwell, J. Herrington, D. Post‐Munson, 2017, Journal of medicinal chemistry.

Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.

N. Meanwell, J. Herrington, D. Post‐Munson, 2017, Journal of medicinal chemistry.

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.

Andrea Mcclure, J. Macor, H. Lewis, 2016, ACS medicinal chemistry letters.

Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates

L. Snyder, L. Thompson, Yong-Jin Wu, 2014 .

Synthesis of β‐Disubstituted β‐Amino Isoxazolyl Ketones by Addition of Ketimines with Isoxazolyl Methyl Ketone Enolates.

L. Snyder, L. Thompson, Yong-Jin Wu, 2014 .

Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.

J. Tokarski, N. Meanwell, Scott W. Martin, 2023, ACS medicinal chemistry letters.