Conor McClenaghan

发表

GPR39 Is Coupled to TMEM16A in Intestinal Fibroblast-Like Cells

M. Nash, J. M. Verkuyl, F. Zeng, 2012, PloS one.

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

B. Schwappach, R. Mecham, C. Nichols, 2021, JCI insight.

TRPA1 agonist activity of probenecid desensitizes channel responses: consequences for screening.

J. M. Verkuyl, F. Zeng, Conor McClenaghan, 2012, Assay and drug development technologies.

Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain‐of‐function variant: Initial experience

T. Roscioli, C. Nichols, D. Grange, 2019, American journal of medical genetics. Part A.

Glibenclamide reverses cardiovascular abnormalities of Cantu Syndrome driven by KATP channel overactivity.

C. Nichols, R. Chalk, M. Remedi, 2019, The Journal of clinical investigation.

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms

C. Nichols, D. Grange, D. Josifova, 2017, The Journal of Biological Chemistry.

Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms

C. Nichols, D. Grange, G. Haaften, 2017, bioRxiv.

Consequences of SUR2[A478V] Mutation in Skeletal Muscle of Murine Model of Cantu Syndrome

C. Nichols, D. Tricarico, A. Mele, 2021, Cells.

Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome

C. Nichols, F. Zito, G. Ranieri, 2020, Frontiers in Pharmacology.

Cardiovascular consequences of KATP overactivity in Cantu syndrome.

Yan Huang, R. Mecham, C. Nichols, 2018, JCI insight.

ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle.

C. Nichols, G. van Haaften, Jennifer M. Ikle, 2021, The Journal of physiology.

Lymphedema as first clinical presentation of Cantu Syndrome: reversed phenotyping after identification of gain-of-function variant in ABCC9

C. Nichols, M. Alders, I. Christiaans, 2022, European Journal of Human Genetics.

Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry

C. Nichols, Jin-Moo Lee, M. Remedi, 2019, American journal of medical genetics. Part C, Seminars in medical genetics.

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

G. F. Ruda, Lishuang Cao, E. Carpenter, 2015, Science.

Sulfonylurea-Insensitive Permanent Neonatal Diabetes Caused by a Severe Gain-of-Function Tyr330His Substitution in Kir6.2

C. Nichols, M. Mucciolo, A. Deodati, 2022, Hormone Research in Paediatrics.

A Unique High‐Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance in Cantu Syndrome

C. Nichols, M. Remedi, D. Grange, 2022, Journal of the American Heart Association.

The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome

C. Nichols, Jin-Moo Lee, M. Remedi, 2020, Function.

Y. Huang, C. Nichols, M. Remedi, 2019, Nature Communications.

Pulmonary Hypertension and ATP-Sensitive Potassium Channels.

C. Nichols, Kel Vin Woo, Conor McClenaghan, 2019, Hypertension.

Clinical Picture and Genetic Basis of Pulmonary Hypertension

C. Nichols, Kel Vin Woo, Conor McClenaghan, 2019 .

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel

C. Nichols, A. Stary-Weinzinger, Xingyu Chen, 2017, The Journal of Biological Chemistry.

Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport

M. Panesar, A. Ropenga, G. Bhalay, 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

E. Carpenter, M. Sansom, A. Pike, 2017, Structure.

Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension

W. Chung, Yufeng Shen, F. Dewey, 2018, Circulation. Genomic and precision medicine.

Coronavirus Proteins as Ion Channels: Current and Potential Research

C. Nichols, Sun-Joo Lee, Conor McClenaghan, 2020, Frontiers in Immunology.

Kir6.1 and SUR2B and Cantú syndrome.

C. Nichols, Conor McClenaghan, 2022, American journal of physiology. Cell physiology.

Beta‐cell excitability and excitability‐driven diabetes in adult Zebrafish islets

D. Piston, D. Meyer, C. Nichols, 2019, Physiological Reports.

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

E. Carpenter, Prafulla Aryal, T. Baukrowitz, 2016, The Journal of general physiology.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

E. Carpenter, M. Sansom, A. Pike, 2017, Structure.

Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS

C. Nichols, G. Meyer, Anamika Dayal, 2023, EMBO molecular medicine.

Electrophysiology of human iPSC-derived vascular smooth muscle cells and cell autonomous consequences of Cantu Syndrome mutations

Amber N. Stratman, C. Nichols, D. Grange, 2023, bioRxiv.

Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

Kenneth A. Matreyek, C. Nichols, D. Grange, 2023, The Journal of Pharmacology and Experimental Therapeutics.

Zoledronic Acid Blocks Overactive Kir6.1/SUR2-Dependent KATP Channels in Skeletal Muscle and Osteoblasts in a Murine Model of Cantú Syndrome

C. Nichols, M. Perrone, A. Scilimati, 2023, Cells.

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel

C. Nichols, A. Stary-Weinzinger, Xingyu Chen, 2017, The Journal of Biological Chemistry.

Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome

Evan Yamasaki, Conor McClenaghan, Yumei Feng Earley, 2024, JCI insight.