T. McCloskey

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Immunomodulation in an Infant with Familial Hemophagocytic Lymphohistiocytosis Following Chemotherapy

M. Frieri, G. Beck, P. Cardenas, 1999 .

Immunophenotypic analysis of HIV-infected children: alterations within the first year of life, changes with disease progression, and longitudinal analyses of lymphocyte subsets.

M. Lesser, S. Pahwa, N. Kohn, 2001, Cytometry.

CD95 expression and apoptosis during pediatric HIV infection: early upregulation of CD95 expression.

N. Oyaizu, S. Pahwa, N. Kohn, 1998, Clinical immunology and immunopathology.

Role of receptor occupancy assays by flow cytometry in drug development

J. Ferbas, V. Litwin, K. Czechowska, 2016, Cytometry. Part B, Clinical cytometry.

Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins.

K. Davies, Ping Wang, V. Haridas, 2005, Free radical biology & medicine.

Apoptosis in T-Lymphocyte Subsets in Human Immunodeficiency Virus-Infected Children Measured Immediately Ex Vivo and following In Vitro Activation

V. Wahn, T. Niehues, S. Pahwa, 2001, Clinical Diagnostic Laboratory Immunology.

Flow Cytometric Detection and Quantification of Apoptotic Cells

S. Pahwa, T. McCloskey, B. Phenix, 2006 .

Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion.

N. Oyaizu, R. Hu, S. Pahwa, 1994, Blood.

Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.

Y. Adachi, H. Yagita, N. Oyaizu, 1997, Journal of immunology.

Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.

N. Chirmule, N. Oyaizu, S. Pahwa, 1997, Clinical immunology and immunopathology.

CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway.

N. Oyaizu, S. Pahwa, S. Than, 2000, Blood.

Alterations in apoptosis of cord and adult peripheral blood mononuclear cells induced by in vitro infection with respiratory syncytial virus.

S. Pahwa, L. Krilov, T. McCloskey, 2000, The Journal of infectious diseases.

Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals.

N. Chirmule, N. Oyaizu, S. Pahwa, 1993, Blood.

Comparison of seven quantitative assays to assess lymphocyte cell death during HIV infection: measurement of induced apoptosis in anti-Fas-treated Jurkat cells and spontaneous apoptosis in peripheral blood mononuclear cells from children infected with HIV.

S. Pahwa, S. Chavan, T. McCloskey, 1998, AIDS research and human retroviruses.

Expression of the Fas antigen in patients infected with human immunodeficiency virus.

M. Kaplan, N. Oyaizu, S. Pahwa, 1995, Cytometry.

Mechanism of apoptosis in peripheral blood mononuclear cells of HIV-infected patients.

N. Oyaizu, R. Hu, S. Pahwa, 1995, Advances in experimental medicine and biology.

Best practices for optimization and validation of flow cytometry‐based receptor occupancy assays

V. Litwin, Steve Eck, C. Green, 2020, Cytometry. Part B, Clinical cytometry.

Immunophenotypic analysis of peripheral blood mononuclear cells undergoing in vitro apoptosis after isolation from human immunodeficiency virus-infected children.

S. Pahwa, S. Than, S. Bakshi, 1998, Blood.

Requirement of p56lck in T-cell receptor/CD3-mediated apoptosis and Fas-ligand induction in Jurkat cells.

N. Oyaizu, S. Pahwa, S. Than, 1995, Biochemical and biophysical research communications.

High‐sensitivity flow cytometric assays: Considerations for design control and analytical validation for identification of Rare events

Virginia Litwin, Cherie Green, Alessandra Vitaliti, 2020, Cytometry. Part B, Clinical cytometry.

Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

C. Van Lint, E. Verdin, M. Ott, 1997, Science.

CD8+ T cells in HIV disease exhibit cytokine receptor perturbation and poor T cell receptor activation but are responsive to gamma-chain cytokine-driven proliferation.

S. Krishnan, S. Pahwa, Olga C. Aroniadis, 2006, The Journal of infectious diseases.

Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion.

N. Oyaizu, S. Pahwa, S. Than, 1996, Blood.

Dual role of HIV Tat in regulation of apoptosis in T cells.

E. Verdin, M. Ott, N. Chirmule, 1997, Journal of immunology.

IL-2 rescues in vitro lymphocyte apoptosis in patients with HIV infection: correlation with its ability to block culture-induced down-modulation of Bcl-2.

Y. Adachi, N. Oyaizu, S. Pahwa, 1996, Journal of immunology.

Use of a flow cytometric assay to quantitate apoptosis in human lymphocytes.

N. Oyaizu, S. Pahwa, T. McCloskey, 1994, Clinical immunology and immunopathology.

Immunophenotyping of T lymphocytes by three-color flow cytometry in healthy newborns, children, and adults.

T. Cavaliere, N. Kohn, S. Bakshi, 1997, Clinical immunology and immunopathology.

A flow cytometric assay for HLA‐DR expression on monocytes validated as a biomarker for enrollment in sepsis clinical trials

M. Hedrick, K. Quadrini, T. McCloskey, 2021, Cytometry. Part B, Clinical cytometry.

Response to Superantigen Stimulation in Peripheral Blood Mononuclear Cells from Children Perinatally Infected with Human Immunodeficiency Virus and Receiving Highly Active Antiretroviral Therapy

V. Haridas, S. Pahwa, T. McCloskey, 2004, Clinical Diagnostic Laboratory Immunology.

Human immunodeficiency virus gag and pol-specific CD8 T cells in perinatal HIV infection.

V. Haridas, S. Pahwa, R. Pahwa, 2001, Cytometry.

Discordant expression of perforin and granzyme A in total and HIV-specific CD8 T lymphocytes of HIV infected children and adolescents

V. Haridas, S. Pahwa, R. Pahwa, 2003, AIDS.

T cell receptor Vβ repertoire of the antigen specific CD8 T lymphocyte subset of HIV infected children

V. Haridas, S. Pahwa, R. Pahwa, 2002 .

HIV-1 gp120 Blocks Jacalin-Induced Proliferative Response in CD4+T Cells: Jacalin as a Useful Surrogate Marker for Qualitative and Quantitative Deficiency of CD4+T Cells in HIV-1 Infection1

N. Oyaizu, S. Pahwa, V. Kalyanaraman, 1996 .

HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).

N. Chirmule, R. Hu, S. Pahwa, 1995, Journal of immunology.

Flow Cytometry and Clinical Trials

T. McCloskey, C. G. Hill, 2011 .

Alterations in T-Cell Receptor Vβ Repertoire of CD4 and CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Children

S. Pahwa, R. Pahwa, M. Kharbanda, 2003, Clinical Diagnostic Laboratory Immunology.

Immunophenotypic analysis of peripheral blood mononuclear cells undergoing in vitro apoptosis after isolation from human immunodeficiency virus-infected children.

S. Bakshi, T. McCloskey, Savita Pahwa, 1998, Blood.