J. Lampe

发表

Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.

H. Jaeschke, A. Farhood, C. Williams, 2011, Toxicology and applied pharmacology.

Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening

S. Kandel, Hannah M. Work, J. Lampe, 2021, Scientific Reports.

Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates

S. Kandel, J. Lampe, 2021, Chemical research in toxicology.

Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4.

W. Atkins, J. Lampe, 2006, Biochemistry.

Inhibit Human Organic Cation Transporter 1 ( OCT 1 )-Mediated Neurotransmitter Uptake

B. Hagenbuch, J. Lampe, Kelli H. Boxberger, 2014 .

Common Drugs Inhibit Human Organic Cation Transporter 1 (OCT1)-Mediated Neurotransmitter Uptake

B. Hagenbuch, J. Lampe, Kelli H. Boxberger, 2014, Drug Metabolism and Disposition.

Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119.

Yigal Brandman, Relly Brandman, Relly Brandman, 2011, Archives of biochemistry and biophysics.

Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.

W. Atkins, A. Nath, J. Lampe, 2008, Archives of biochemistry and biophysics.

Nile Red is a fluorescent allosteric substrate of cytochrome P450 3A4.

W. Atkins, A. Nath, J. Lampe, 2008, Biochemistry.

NMR studies of ligand binding to P450(eryF) provides insight into the mechanism of cooperativity.

M. Bowman, W. Atkins, A. Roberts, 2006, Biochemistry.

Analysis of Cytochrome P450 CYP119 Ligand-dependent Conformational Dynamics by Two-dimensional NMR and X-ray Crystallography*

S. Kandel, P. D. de Montellano, C. Nishida, 2015, The Journal of Biological Chemistry.

Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement.

S. Kandel, Hannah M. Work, J. Lampe, 2023, Journal of inorganic biochemistry.

Two-dimensional NMR and All-atom Molecular Dynamics of Cytochrome P450 CYP119 Reveal Hidden Conformational Substates*

Relly Brandman, Relly Brandman, Jed N Lampe, 2010, The Journal of Biological Chemistry.

Antisense Oligonucleotides Containing Modified Bases Inhibit in Vitro Translation of Leishmania amazonensis mRNAs by Invading the Mini-exon Hairpin*

J. Toulmé, E. Lukhtanov, H. Gamper, 1999, The Journal of Biological Chemistry.

Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections

D. Fish, A. Horswill, Sarah K. Parker, 2022, Microbiology spectrum.

Aqueous synthesis of a small-molecule lanthanide chelator amenable to copper-free click chemistry

R. Winefield, A. Anbanandam, J. Lampe, 2019, PloS one.

Case Studies in Modern Drug Discovery and Development

J. Lampe, 2013 .

Role of Cysteine Residues in Heme Binding to Human Heme Oxygenase-2 Elucidated by Two-dimensional NMR Spectroscopy*

P. Ortiz de Montellano, J. Lampe, F. Varfaj, 2012, The Journal of Biological Chemistry.

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction.

U. Apte, S. Gunewardena, Steven R. McGreal, 2016, Toxicology and applied pharmacology.

Role of Protein–Protein Interactions in Cytochrome P450-Mediated Drug Metabolism and Toxicity

S. Kandel, Sylvie E. Kandel, Jed N. Lampe, 2014, Chemical research in toxicology.

Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE

S. Kandel, Hannah M. Work, B. Tooker, 2021, bioRxiv.

Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism.

Haixing Li, J. Lampe, 2019, Archives of biochemistry and biophysics.

Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development.

L. Wienkers, S. Kandel, J. Lampe, 2014, Annual reports in medicinal chemistry.

Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques

J. Lampe, 2017, Front. Pharmacol..

Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.

P. Ortiz de Montellano, M. Trnka, S. Floor, 2008, Journal of the American Chemical Society.

Ligand‐dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel

B. Hagenbuch, J. Lampe, Kelli H. Boxberger, 2018, Biochemical pharmacology.

Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7

Qingcheng Mao, S. Kandel, J. Lampe, 2017, Drug Metabolism and Disposition.

Digging deeper into CYP 3 A testosterone metabolism : kinetic , regio-and stereoselectivity differences between CYP 3 A 4 / 5 and CYP 3 A 7

Qingcheng Mao, S. Kandel, J. Lampe, 2017 .

Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.

W. Atkins, A. Roberts, S. Nelson, 2006, Archives of biochemistry and biophysics.

Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors

S. Kandel, J. Lampe, Emily G. Hicks, 2022, Bioorganic & Medicinal Chemistry Letters.

Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate

S. Kandel, E. Scott, J. Lampe, 2023, The Journal of biological chemistry.

Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims

Weng-Lang Yang, Devin M Boe, E. Kovacs, 2023, Communications biology.

Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach.

S. Kandel, J. Lampe, Emily G Gracey, 2023, Chemical research in toxicology.

Case Studies in Modern Drug Discovery and Development

J. Lampe, 2013 .

Probing the CYP3A4 active site by cysteine scanning mutagenesis and photoaffinity labeling.

W. Atkins, A. Roberts, S. Nelson, 2005, Archives of biochemistry and biophysics.

Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1

S. Kandel, J. Lampe, Brian C Tooker, 2024, The Journal of biological chemistry.