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发表

Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage.

O. Rabal, J. Oyarzábal, J. Paramo, 2015, Journal of medicinal chemistry.

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.

P. Walsh, J. Orbe, J. Hermida, 2015, Blood.

THROMBOSIS AND HEMOSTASIS Activated protein C b-glycoform promotes enhanced noncanonical PAR 1 proteolysis and superior resistance to ischemic injury

G. Dichiara, P. Walsh, J. Orbe, 2015 .

Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.

O. Rabal, J. Oyarzábal, Hongyu Ma, 2018, ACS medicinal chemistry letters.

Design, synthesis, and biological evaluation of novel matrix metalloproteinase inhibitors as potent antihemorrhagic agents: from hit identification to an optimized lead.

O. Rabal, J. Oyarzábal, Hongyu Ma, 2015, Journal of medicinal chemistry.

MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes

O. Rabal, J. Paramo, M. Navarro-Oviedo, 2018, Translational Stroke Research.

MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes

O. Rabal, J. Paramo, E. Toledo, 2018, Translational Stroke Research.

New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator

J. Montaner, D. Vivien, A. Rosell, 2017, Cardiovascular research.