M. Ruppen

发表

PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors

P. Frost, J. Skotnicki, P. Cai, 2005, Cancer biology & therapy.

Degradation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase in vivo.

R. Switzer, M. Ruppen, 1983, The Journal of biological chemistry.

Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates.

J. Gibbons, J. Lucas, Jianxin Gu, 2010, Journal of medicinal chemistry.

Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.

J. Skotnicki, P. Cai, J. Gibbons, 2006, Journal of medicinal chemistry.

NMR structural analysis of the capsular polysaccharide from Streptococcus pneumoniae serotype 6C.

P. Cai, J. Moran, V. Pavliak, 2012, Carbohydrate research.

Protein turnover in Azotobacter vinelandii during encystment and germination

H. Sadoff, M. Ruppen, G. Garner, 1983, Journal of bacteriology.

PLACENTAL FUNCTION IN PROSTAGLANDIN INDUCED LABOUR

P. Keller, M. Ruppen, P. Keller, 1972, The Journal of obstetrics and gynaecology of the British Commonwealth.

Chemical Steps in the Selective Inactivation and Degradation of Glutamine Phosphoribosylpyrophosphate Amidotransferase in Bacillus subtilis

D. Bernlohr, R. Switzer, M. Ruppen, 1981 .

EFFICIENT EXPRESSION OF HUMAN GROWTH HORMONE IN BACILLUS SUBTILIS

M. Ruppen, 1986 .

A continuous assay for DNA cleavage: the application of "break lights" to enediynes, iron-dependent agents, and nucleases.

J. Thorson, J. Prudent, J. Biggins, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Mannosidase chemistry of the mannopeptimycin complex

P. Cai, J. Lotvin, Ming Liu, 2004 .

Hygrocins a and B, naphthoquinone macrolides from Streptomyces hygroscopicus.

Greg F. Glasier, P. Cai, G. Carter, 2005, Journal of natural products.

Facile conversion of tetracycline antibiotics to 4,11a-bridged derivatives via oxidative mannich cyclization

P. Cai, Jianxin Gu, M. Ruppen, 2010, Journal of antibiotics (Tokyo. 1968).

Facile conversion of tetracycline antibiotics to 4,11a-bridged derivatives via oxidative mannich cyclization

P. Cai, Jianxin Gu, M. Ruppen, 2011, The Journal of Antibiotics.

Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

J. Thorson, E. Sievers, J S Thorson, 2000, Current pharmaceutical design.

Involvement of the stringent response in degradation of glutamine phosphoribosylpyrophosphate amidotransferase in Bacillus subtilis

R. Switzer, M. Ruppen, 1983, Journal of bacteriology.

Polyene antibiotics from Streptomyces mediocidicus.

P. Fink, R. Williamson, P. Cai, 2007, Journal of Natural Products.

Control of intracellular serine protease expression in Bacillus subtilis

M. Ruppen, L. Band, G. V. Van Alstine, 1988, Journal of bacteriology.

Construction and properties of an intracellular serine protease mutant of Bacillus subtilis

D. Henner, M. Ruppen, L. Band, 1987, Journal of bacteriology.

In Vitro Metabolic Study of Temsirolimus: Preparation, Isolation, and Identification of the Metabolites

P. Cai, R. Tsao, M. Ruppen, 2007, Drug Metabolism and Disposition.

lipase-catalyzed regioselective esterification of rapamycin: synthesis of temsirolimus (CCI-779).

P. Cai, M. Ruppen, J. Gu, 2005, Organic letters.

Involvement of the stringent response in regulation of protein degradation in Bacillus subtilis.

R. Switzer, R. Bond, S. Rosenzweig, 1985, Current topics in cellular regulation.