T. Imbert

发表

F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.

J. Annereau, C. Bailly, J. Barret, 2008, Cancer research.

Requirements for P-glycoprotein recognition based on structure-activity relationships in the podophyllotoxin series.

B. Hill, C. Etiévant, J. Barret, 1998, Anti-cancer drug design.

Discovery of podophyllotoxins.

T. Imbert, 1998, Biochimie.

Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system

C. Bailly, J. Barret, A. Kruczynski, 2011, Investigational New Drugs.

F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action.

B. Hill, B. van Hille, C. Etiévant, 2000, Biochemical pharmacology.

Synthesis of Furo[3,2-b]pyridine Analogue of Efaroxan

T. Imbert, Patrice Mayer, C. Loubat, 1998 .

Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611.

B. Hill, C. Etiévant, A. Kruczynski, 1998, Journal of medicinal chemistry.

Synthesis of podophyllotoxin A-ring pyridazine analogue

C. Monneret, E. Bertounesque, T. Imbert, 1996 .

Practical Demethylation of Podophyllotoxin and Efficient Preparation of 4-Amino-4-deoxy-4′-demethylepipodophyllotoxin

Y. Guminski, T. Imbert, M. Grousseaud, 2012 .

Synthetic approaches to condensed aromatic analogues from etoposide. Synthesis of A-ring pyridazine picroetoposide

C. Monneret, E. Bertounesque, T. Imbert, 1999 .

A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment.

J. Annereau, C. Bailly, J. Barret, 2010, Leukemia research.

Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system.

J. Annereau, C. Bailly, J. Barret, 2009, Bioorganic & medicinal chemistry letters.

Antitumor activity of pyridoisoquinoline derivatives F91873 and F91874, novel multikinase inhibitors with activity against the anaplastic lymphoma kinase

J. Annereau, C. Bailly, A. Marchand, 2009, Anti-cancer drugs.

99mTc-HYNIC-spermine for imaging polyamine transport system-positive tumours: preclinical evaluation

C. Bailly, A. Kruczynski, S. Lerondel, 2011, European Journal of Nuclear Medicine and Molecular Imaging.

CRE 10904 [2-(p-fluorophenoxy), 1-(o-hydroxyphenyl)-ethane]: a new diuretic and antihypertensive drug acting by in vivo sulfation.

G. Moinet, C. Nazaret, R. Garay, 1990, The Journal of pharmacology and experimental therapeutics.

Preclinical antitumour activity of F 11782, a novel dual catalytic inhibitor of topoisomerases

F. Colpaert, B. Hill, C. Etiévant, 2000, British Journal of Cancer.

A new efficient synthesis of efaroxan.

P. Brunel, T. Imbert, P. Mayer, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system.

J. Annereau, C. Bailly, J. Barret, 2009, Bioorganic & medicinal chemistry letters.