E. Menta

发表

Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer.

G. Pezzoni, B. Ruggeri, J. Mallamo, 2008, Journal of medicinal chemistry.

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers.

S. Moro, G. Capranico, M. Palumbo, 2004, Biochemical pharmacology.

Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent

S. Cutts, D. Phillips, Benny J. Evison, 2007, Nucleic acids research.

BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin.

N. Farrell, F. Zunino, R. Supino, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

1-[(omega-aminoalkyl)amino]-4-[N-(omega-aminoalkyl)carbamoyl]-9-oxo-9, 10-dihydroacridines as intercalating cytotoxic agents: synthesis, DNA binding, and biological evaluation.

L. Kèlland, S. Martelli, B. Stefańska, 1997, Journal of medicinal chemistry.

A Novel 9-Aza-Anthrapyrazole Effective against Human Prostatic Carcinoma Xenografts

F. Zunino, G. Capranico, M. Palumbo, 2001, Oncology.

Bbr 2778, an Aza-anthracenedione Endowed with Preclinical Anticancer Activity and Lack of Delayed Cardiotoxicity

C. Manzotti, G. Pezzoni, F. Sala, 2001, Tumori.

Novel antineoplastic agents

M. Palumbo, E. Menta, 1997 .

Mapping Drug Interactions at the Covalent Topoisomerase II-DNA Complex by Bisantrene/Amsacrine Congeners*

S. Moro, B. Gatto, F. Zunino, 1998, The Journal of Biological Chemistry.

The synthesis of 6,9‐bis[(aminoalkyl)amino] substituted benzo[g]quinoxaline‐, benzo[g]quinazoline‐ and benzo‐[g]phthalazine‐5,10‐diones via regiospecific displacements

M. Hacker, A. P. Krapcho, K. Rosner, 1993 .

2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione derivatives, a class of cytotoxic agents active on multidrug-resistant cell lines: synthesis, biological evaluation, and structure-activity relationships.

L. Kèlland, S. Martelli, I. Antonini, 1999, Journal of medicinal chemistry.

A New Facile Synthesis of 4-Oxo-1,4-dihydrocinnolines

A. Papagni, C. Baldoli, E. Licandro, 1987 .

Synthesis of 1,4-Dihydropyridines by Regioselective Additions of Benzylic Zinc Bromides to Pyridinium Salts and Their Aromatizations to 4-Benzylpyridines

A. P. Krapcho, A. Hammach, D. Waterhouse, 1997 .

Synthesis of regioisomeric 6,9-(chlorofluoro)-substituted benzo[g]quinoline-5,10-diones, benzo[g] isoquinoline-5,10-diones and 6-chloro-9-fluorobenzo[g]quinoxaline-5,10-dione

C. Gallagher, A. P. Krapcho, A. Hammach, 1997 .

Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors

H. Krell, H. Brandstetter, H. Leinert, 2001, Biological chemistry.

Research on MMP Inhibitors with Unusual Scaffolds

H. Krell, R. Engh, H. Brandstetter, 2001 .

Stability of Boronic Esters to Hydrolysis : A Comparative Study

L. Goldoni, E. Menta, R. Bernardini, 2009 .

Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4, 3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles).

G. Pezzoni, M. Hacker, C. Gallagher, 1998, Journal of medicinal chemistry.

Selective Platination of Biologically Relevant Polyamines. Linear Coordinating Spermidine and Spermine as Amplifying Linkers in Dinuclear Platinum Complexes

N. Farrell, E. Menta, A. Oliva, 1997 .

N-tert-butoxycarbonyl-N-substituted hydrazines in SNAr displacements. Synthetic pathways to N-1-substituted anthrapyrazoles, aza-anthrapyrazoles and aza-benzothiopyranoindazoles

A. P. Krapcho, E. Menta, A. Oliva, 2000 .

SYNTHESIS OF HYDROXY-SUBSTITUTED AZA-ANALOGUES OF ANTITUMOR ANTHRAPYRAZOLES

M. Hacker, A. P. Krapcho, A. Hammach, 1998 .

2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents.

B. Gatto, M. Palumbo, S. Martelli, 2002, Journal of medicinal chemistry.

Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents.

B. Gatto, M. Palumbo, S. Martelli, 2003, Journal of medicinal chemistry.

A New Facile Synthesis of 4-Oxo-1,4-dihydrocinnolines.

A. Papagni, C. Baldoli, E. Licandro, 1987 .

Synthesis of 1,4-Dihydropyridines (IV) by Regioselective Additions of Benzylic Zinc Bromides to Pyridinium Salts and Their Aromatizations to 4-Benzylpyridines (V).

A. P. Krapcho, A. Hammach, D. Waterhouse, 1997 .

Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition.

M. Boxer, M. Palumbo, D. Maloney, 2007, Bioorganic & medicinal chemistry.

Physicochemical properties, cytotoxic activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones.

F. Zunino, G. Capranico, M. Palumbo, 1997, Biochemical pharmacology.

Pyrimido [4,5,6-kl] acridines, a new class of potential anticancer agents. Synthesis and biological evaluation.

S. Martelli, M. Bontemps-Gracz, I. Antonini, 1996, Anti-cancer drug design.

Synthesis and antitumor activities of 5-methyl-1- and 2-[[2-dimethylaminoethyl]amino]-aza-thiopyranoindazoles.

M. Hacker, S. Haydar, A. P. Krapcho, 2000, Bioorganic & medicinal chemistry letters.

Synthesis of 4‐hydroxy‐6,9‐difluorobenz[g]isoquinoline‐5,10‐diones and conversions to 4‐hydroxy‐6,9‐bis[(aminoalkyl)amino]‐benz[g]isoquinoline‐5,10‐diones

M. Hacker, C. Gallagher, A. P. Krapcho, 1995 .

ATP non-competitive Ser/Thr kinase inhibitors as potential anticancer agents.

S. Moro, A. Bortolato, G. Cozza, 2009, Anti-cancer agents in medicinal chemistry.

Antineoplastic agents 1998

M. Palumbo, E. Menta, 1998 .

Inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2‐indolinone derivative

M. Borrello, M. Pierotti, F. Zunino, 2000, International journal of cancer.

Advances in Brief BBR 3464 : A Novel Triplatinum Complex , Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin 1

N. Farrell, F. Zunino, R. Supino, 2000 .

Anthracene-9,10-Diones and Aza Bioisosteres as Antitumor Agents

G. Pezzoni, M. Hacker, L. Hazelhurst, 1995, Current Medicinal Chemistry.

Aza and diaza bioisosteric anthracene-9,10-diones as antitumor agents.

M. Hacker, F. Giuliani, S. Spinelli, 1995, Acta Biochimica Polonica.

Preparation of Thieno[3,2‐h]cinnolinones as Matrix Metalloproteinase Inhibitors

A. Ferrari, G. Rastelli, H. Krell, 2000, Archiv der Pharmazie.

Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine.

N. Pescalli, E. Menta, L. Piazzoni, 2001, Farmaco.