P. Fleming

发表

Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.

M. Rolfe, A. Berger, Jie Yu, 2010, Cancer research.

Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy.

L. Dick, P. Fleming, 2010, Drug discovery today.

Characterization of a New Series of Non-covalent Proteasome Inhibitors with Exquisite Potency and Selectivity for the 20s Β5-subunit Figure S1 Activities of Compound 1 and Bortezomib in Cells

T. Soucy, E. Olhava, M. Sintchak, 2010 .

Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis.

H. Brewer, A. Remaley, S. Stefansson, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6tx00220j

L. Dick, F. Wolenski, V. Csizmadia, 2016, Toxicology research.

Proteasome inhibitors bortezomib and car fi lzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA 2 / Omi †

L. Dick, F. Wolenski, V. Csizmadia, 2016 .

Genetic transformation of mature Taxus: an approach to genetically control the in vitro production of the anticancer drug, taxol

M. Gordon, W. Chilton, Kyung-Hwan Han, 1994 .

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Jonathan L Blank, Christopher Tsu, Christopher Blackburn, 2010, Bioorganic & medicinal chemistry letters.

Precision Targeted Therapy with BLU-667 for RET-Driven Cancers.

S. Ou, C. Lengauer, Wei Hu, 2018, Cancer discovery.

The synthesis and characterization of 8-methoxy-5'-deoxyadenosylcobalamin: a coenzyme B(12) analog which, following Co-C bond homolysis, avoids cyclization of the 8-methoxy-5'-deoxyadenosyl radical.

K. Doll, R. Finke, P. Fleming, 2002, Journal of inorganic biochemistry.

Rare .alpha.-alkyl isomers of cobalamins: synthesis, characterization, and properties of two diastereomers of the .alpha.-alkylcobalamin, .alpha.-(2-oxo-1,3-dioxolan-4-yl)cobalamin

L. Marzilli, Yun Alelyunas, R. Finke, 1991 .

The coenzyme B12 derivative N1-methyl-5'-deoxyadenosylcobalamin: synthesis, characterization, stability towards dimroth rearrangement, and Co-C thermolysis product and kinetic studies.

R. Finke, P. Fleming, B. E. Daikh, 1998, Journal of Inorganic Biochemistry.

MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model

D. Soler, N. Tsuchimori, E. Fedyk, 2018, International immunopharmacology.

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

S. Tirrell, J. Newcomb, T. Soucy, 2018, Nature Medicine.

Biosynthesis of Taxoids. Mode of Attachment of the Taxol Side Chain

Xian-guo He, H. Floss, U. Mocek, 1994 .

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

T. Soucy, E. Olhava, M. Sintchak, 2010, The Biochemical journal.

Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea

A. Berger, Jie Yu, L. Dick, 2011, Cancer Chemotherapy and Pharmacology.

Biosynthesis of taxoids. Mode of formation of the taxol side chain

H. Floss, U. Mocek, P. Fleming, 1993 .