C. Molineaux

发表

Increased dynorphin immunoreactivity in spinal cord after traumatic injury

A. Faden, T. Jacobs, J. Rosenberger, 1985, Regulatory Peptides.

Safety and Antitumor Efficacy of the Proteasome Inhibitor Carfilzomib (PR-171) Dosed for Five Consecutive Days in Hematologic Malignancies: Phase 1 Results.

R. Orlowski, O. O’Connor, L. Kunkel, 2007 .

Phase 1 Single Agent Antitumor Activity of Twice Weekly Consecutive Day Dosing of the Proteasome Inhibitor Carfilzomib (PR-171) in Hematologic Malignancies.

S. Trudel, A. Goy, M. Alsina, 2007 .

Multicenter Phase I Studies To Evaluate the Safety, Tolerability, and Clinical Response to Intensive Dosing with the Proteasome Inhibitor PR-171 in Patients with Relapsed or Refractory Hematological Malignancies.

S. Trudel, R. Orlowski, O. O’Connor, 2006 .

A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization

W. Greenlee, S. E. D. Laszlo, R. Rivero, 1997 .

Cancer Therapy : Clinical A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib ( PR-171 ) in Patients with Hematologic Malignancies

R. Orlowski, A. Stewart, O. O’Connor, 2009 .

A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies

R. Orlowski, A. Stewart, O. O’Connor, 2009, Clinical Cancer Research.

Protection from mutagenic effects of antischistosomal and other drugs.

P. Talalay, Y. Cha, E. Bueding, 1978, Pharmacological reviews.

Inhibition of Endopeptidase‐24.15 Decreases Blood Pressure in Normotensive Rats

E. Genden, C. Molineaux, 1991, Hypertension.

Upregulation of Endogenous Erythropoietin (EPO) in Healthy Subjects by Inhibition of Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase.

L. Flippin, M. Brenner, Al Y. Lin, 2004 .

An Inhibitor of Endopeptidase‐24.15 Blocks the Degradation of Intraventricularly Administered Dynorphins

J. Ayala, C. Molineaux, 1990, Journal of neurochemistry.

Synaptosomal Membrane‐Bound Form of Endopeptidase‐24.15 Generates Leu‐Enkephalin from Dynorphin 1‐8, α‐ and β‐Neoendorphin, and Met‐Enkephalin from Met‐Enkephalin‐Arg6‐Gly7‐Leu

M. Orłowski, C. Molineaux, G. R. Acker, 1987 .

Development of C5a receptor antagonists. Differential loss of functional responses.

H. Rosen, Z. Konteatis, P. Fischer, 1994, Journal of immunology.

Response of rat pituitary anterior lobe prodynorphin products to changes in gonadal steroid environment.

J. Rosenberger, C. Molineaux, B. Cox, 1986, Endocrinology.

Dynorphins and leu-enkephalin in brain nuclei and pituitary of WKY and SHR rats

A. Faden, G. Feuerstein, B. Cox, 1983, Peptides.

Distribution of immunoreactive dynorphin in discrete brain nuclei; comparison with vasopressin

G. Feuerstein, A. Faden, C. Molineaux, 1982, Neuroscience Letters.

The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

J. Demartino, H. Rosen, Z. Konteatis, 1994, The Journal of biological chemistry.

Effects of traumatic injury on dynorphin immunoreactivity in spinal cord

A. Faden, B. Cox, T. Jacobs, 1985, Neuropeptides.

Excretion of Carfilzomib in Rats

M. Bennett, C. Kirk, Zhengping Wang, 2011 .

Endopeptidase‐24.15 Is the Primary Enzyme that Degrades Luteinizing Hormone Releasing Hormone Both In Vitro and In Vivo

M. Orłowski, C. Michaud, C. Molineaux, 1988, Journal of neurochemistry.

The Selective Proteasome Inhibitor Carfilzomib Is Well Tolerated in Experimental Animals with Dose Intensive Administration

M. Aujay, T. Muchamuel, M. Bennett, 2008 .

Dynorphin-A-(1-8) is contained within vasopressin neurosecretory vesicles in rat pituitary.

H. Gainer, M. Whitnall, C. Molineaux, 1983, Science.

Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats

M. Bennett, C. Kirk, Zhengping Wang, 2011, Drug Metabolism and Disposition.

Endopeptidase-24.15 in rat hypothalamic/pituitary/gonadal axis

J. Ayala, C. Molineaux, A. Pierotti, 1991, Molecular and Cellular Endocrinology.

Distribution of endopeptidase-24.15 in rat brain nuclei using a novel fluorogenic substrate: Comparison with endopeptidase-24.11

B. Yu, J. Ayala, C. Molineaux, 1991, Neuropeptides.

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome.

S. Demo, M. Aujay, M. Bennett, 2007, Cancer research.

A Phase I Dose-Escalation and Expansion Study of Telaglenastat in Patients with Advanced or Metastatic Solid Tumors

M. Voss, A. DeMichele, F. Meric-Bernstam, 2021, Clinical Cancer Research.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, Brian D. Kelly, 2016, Journal of Immunotherapy for Cancer.

M. Orłowski, C. Michaud, C. Molineaux, 1988, Biochemistry.

Inhibition of endopeptidase 24.15 slows the in vivo degradation of luteinizing hormone-releasing hormone.

M. Orłowski, S. Reznik, C. Molineaux, 1989, The Journal of pharmacology and experimental therapeutics.

Safety and tolerability of increasing doses of CB-839, a first-in-class, orally administered small molecule inhibitor of glutaminase, in solid tumors.

E. Mittra, A. DeMichele, F. Meric-Bernstam, 2015 .

A Phase I Single-Agent Study of Twice-Weekly Consecutive-Day Dosing of the Proteasome Inhibitor Carfilzomib in Patients with Relapsed or Refractory Multiple Myeloma or Lymphoma

S. Trudel, O. O’Connor, A. Goy, 2012, Clinical Cancer Research.

Regulation of beta-endorphin secretion by corticotropin-releasing factor in the intact rat testis.

B. Schachter, C. Molineaux, N. Eskeland, 1992, Endocrinology.

Effect of hemorrhage on vasopressin, dynorphin A, and leu5-enkephalin in the hypothalamo-pituitary system of the rat.

A. Faden, G. Feuerstein, R. Zerbe, 1984, Clinical and experimental hypertension. Part A, Theory and practice.

Conversion of amoscanate to a mutagenic metabolite in gnotobiotic mice implanted with Streptococcus equinus

E. Bueding, B. Reddy, C. Molineaux, 1982, Antimicrobial Agents and Chemotherapy.

Mutagenic activation of an antischistosomal drug by enteric Streptococcus sps in vitro and in vivo.

E. Bueding, C. Molineaux, W. Schmidt, 1980, Teratogenesis, carcinogenesis, and mutagenesis.

Pharmacokinetics, Pharmacodynamics, Metabolism, Distribution, and Excretion of Carfilzomib in Rats

M. Bennett, C. Kirk, Zhengping Wang, 2011, Drug Metabolism and Disposition.

Antinociceptive properties of inhibitors of endopeptidase 24.15.

R. Bodnar, M. Orłowski, B. Kest, 1991, The International journal of neuroscience.

Synaptosomal membrane-bound form of endopeptidase-24.15 generates Leu-enkephalin from dynorphin1-8, alpha- and beta-neoendorphin, and Met-enkephalin from Met-enkephalin-Arg6-Gly7-Leu8.

M. Orłowski, C. Molineaux, G. R. Acker, 1987, Journal of neurochemistry.