R. Matesanz

发表

The total synthesis and biological properties of the cytotoxic macrolide FD-891 and its non-natural (Z)-C12 isomer.

I. Barasoain, J. Díaz, J. F. Díaz, 2007, Chemistry.

New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.

I. Barasoain, C. Galmarini, M. Peñalva, 2013, ACS chemical biology.

Synthesis and biological activities of high affinity taxane-based fluorescent probes.

I. Barasoain, W. Fang, R. Matesanz, 2009, Bioorganic & medicinal chemistry letters.

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

I. Barasoain, E. Calvo, R. Buey, 2007, Nature chemical biology.

A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.

F. Gago, A. Morreale, J. Klett, 2013, Organic & biomolecular chemistry.

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

A. Jantsch, K. Altmann, J. Gertsch, 2016, Molecules.

Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.

K. Altmann, J. Díaz, J. Gertsch, 2009, Chemistry.

Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies.

Anna Ivana Scovassi, Ettore Novellino, Andrea Brancale, 2007, Journal of medicinal chemistry.

Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.

K. Altmann, I. Barasoain, J. Díaz, 2012, Chemistry & biology.

Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.

I. Barasoain, J. Díaz, E. Calvo, 2012, Biochemistry.

Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.

Federico Gago, F. Gago, I. Barasoain, 2008, Chemistry & biology.

Overcoming Tumor Drug Resistance with High‐Affinity Taxanes: A SAR Study of C2‐Modified 7‐Acyl‐10‐Deacetyl Cephalomannines

I. Barasoain, F. Sharom, Ronghua Liu, 2007, ChemMedChem.

The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin.

Jesús Jiménez-Barbero, Ian Paterson, I. Paterson, 2008, Chemistry.

Identification and Characterization of Carboxyl Esterases of Gill Chamber-Associated Microbiota in the Deep-Sea Shrimp Rimicaris exoculata by Using Functional Metagenomics

T. Nechitaylo, M. Ferrer, O. Reva, 2015, Applied and Environmental Microbiology.

Probing the pore drug binding site of microtubules with fluorescent taxanes: evidence of two binding poses.

Maurizio Botta, Mattia Mori, Giorgio Maccari, 2010, Chemistry & biology.

Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats.

M. Ferrer, P. Stogios, A. Savchenko, 2015, Environmental microbiology.

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

A. Nogales, I. Barasoain, I. Ojima, 2014, Bioorganic & medicinal chemistry.

Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin.

M. Steinmetz, S. Wendeborn, I. Barasoain, 2017, Cell chemical biology.

Synthesis, biological evaluations, and tubulin binding poses of C-2alpha sulfur linked taxol analogues.

J. Snyder, I. Barasoain, Ana A. Alcaraz, 2007, Bioorganic & Medicinal Chemistry Letters.

Enzyme adaptation to habitat thermal legacy shapes the thermal plasticity of marine microbiomes

D. Daffonchio, H. Gohlke, M. Ferrer, 2023, Nature Communications.

Thermodynamics as a Tool for the Optimization of Drug Binding, Thermodynamics - Interaction Studies - Solids, Liquids and Gases

J. Díaz, Benet Pera, R. Matesanz, 2011 .

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.

F. Gago, J. Díaz, F. Josa-Prado, 2023, European journal of medicinal chemistry.

Modulation of microtubule interprotofilament interactions by modified taxanes.

A. Nogales, J. Díaz, W. Bras, 2011, Biophysical journal.

Molecular adaptation of Lactobacillus plantarum WCFS1 to gallic acid revealed by genome-scale transcriptomic signature and physiological analysis

B. de Las Rivas, R. Muñoz, R. Matesanz, 2015, Microbial Cell Factories.

Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.

K. Altmann, J. Díaz, J. Gertsch, 2009, Chemistry.

Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex.

J. Díaz, J. L. Asensio, Á. Bastida, 2012, Chemistry.

PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin

D. Lucena‐Agell, P. Avilés, M. Guillén, 2024, Journal of Medicinal Chemistry.