T. Naka

发表

Orally active GPIIb/IIIa antagonists: synthesis and biological activities of masked amidines as prodrugs of 2-[(3S)-4.

M. Kawamura, T. Miyawaki, S. Kitamura, 2001, Chemical & pharmaceutical bulletin.

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl

K. Kubo, Y. Inada, Masakuni Noda, 1993, The Journal of pharmacology and experimental therapeutics.

Purification and characterization of polyamine aminotransferase of Arthrobacter sp. TMP-1.

S. Kondo, T. Naka, T. Yorifuji, 1997, Journal of biochemistry.

Novel non-peptide GPIIb/IIIa antagonists: synthesis and biological activities of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2-oxoethyl)-2-oxopiperazinyl] acetic acids.

M. Kawamura, T. Miyawaki, S. Kitamura, 2001, Chemical & pharmaceutical bulletin.

Non-peptide Angiotensin II Receptor Antagonists

K. Kubo, T. Naka, Y. Furukawa, 1995 .

Antihypertensive effects of a highly potent and long-acting angiotensin II subtype-1 receptor antagonist, (+-)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H- benzimidazole-7-carboxylate (TCV-116), in various hypertensive rats.

K. Kubo, Y. Inada, T. Naka, 1994, The Journal of pharmacology and experimental therapeutics.

Evaluation and improvement of bioavailability of a new angiotensin II receptor antagonist, 2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1H-benzimidazole-7-carboxylic acid by making prodrug☆

Y. Yoshimura, N. Tada, K. Kubo, 1994 .

Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist.

K. Kubo, Y. Inada, T. Naka, 1993, Biochemical pharmacology.

A new class of angiotensin II receptor antagonists with a novel acidic bioisostere

E. Imamiya, K. Kubo, Y. Inada, 1995 .

Non‐Peptide Angiotensin II Receptor Antagonists

K. Kubo, T. Naka, Y. Furukawa, 1996 .

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.

T. Kato, Y. Yoshimura, K. Kubo, 1993, Journal of medicinal chemistry.

Nonpeptide Angiotensin II Receptor Antagonists. Synthesis and Biological Activity of Potential Prodrugs of Benzimidazole‐7‐ carboxylic Acids.

Y. Yoshimura, K. Kubo, Y. Inada, 1993 .

Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres.

E. Imamiya, K. Kubo, Y. Inada, 1996, Journal of medicinal chemistry.

Fused pyrimidines. V. Synthesis of 2-aminopyrimido[4,5-e]-1,3,4-thiadiazine and some related compounds from 6-thiosemicarbazidouracils.

T. Naka, Y. Furukawa, 1979 .

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.

E. Imamiya, K. Kubo, Y. Inada, 1993, Journal of medicinal chemistry.

Dipeptide formation with misacylated tRNAPhes.

S. Hecht, T. Naka, T. G. Heckler, 1983, The Journal of biological chemistry.

Preparation of '2,('3)-O-Acyl-pCpA derivatives as substrates for T4 RNA ligase-mediated “chemical aminoacylation”

S. Hecht, T. Naka, L. Chang, 1984 .

T4 RNA ligase mediated preparation of novel "chemically misacylated" tRNAPheS.

S. Hecht, L. Chang, M. Chorghade, 1984, Biochemistry.

Potent dibasic GPIIb/IIIa antagonists with reduced prolongation of bleeding time: synthesis and pharmacological evaluation of 2-oxopiperazine derivatives.

N. Konishi, M. Kawamura, T. Miyawaki, 2001, Journal of medicinal chemistry.

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles.

K. Kubo, Y. Inada, T. Naka, 1993, Journal of medicinal chemistry.

Synthesis of 5-amino-5-deoxy-α-D-allofuranuronic acid derivative, a sugar component of polyoxins synthesis in nucleoside antibiotics, part VII

T. Naka, T. Hashizume, M. Nishimura, 1971 .

A facile synthesis of 3‐Substituted 5‐Oxo‐1,2,4‐thiadiazoles from amidoximes

E. Imamiya, K. Kubo, T. Naka, 2000 .

Pharmacological profile of a novel nonpeptide angiotensin II subtype 1 receptor antagonist, TCV-116.

K. Kubo, Y. Inada, T. Naka, 1994, Blood pressure. Supplement.