Puwen Zhang

发表

1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.

L. Leventhal, E. Koury, D. Deecher, 2010, Journal of medicinal chemistry.

Synergistic non-bonding interactions based on diketopyrrolo-pyrrole for elevated photoacoustic imaging-guided photothermal therapy.

Yongwei Huang, Zhonghua Liu, Feiyan Ma, 2020, Biomaterials science.

Changes in miR-29 levels and their predictive value of a cure after diamminedichloroplatinum chemotherapy in patients with nasopharyngeal carcinoma

You Wang, Minghui Zhou, Puwen Zhang, 2020 .

Regiospecific Bromination of 3-Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides(1).

J. Cook, Puwen Zhang, T. Gan, 1997, The Journal of organic chemistry.

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).

R. Winneker, E. Melenski, Jeff Cohen, 2008, Journal of medicinal chemistry.

Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.

R. Winneker, Eugene A. Terefenko, J. Wrobel, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget.

R. Winneker, R. Chopra, K. Svenson, 2005, Journal of medicinal chemistry.

Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines.

R. Winneker, J. Wrobel, Zhiming Zhang, 2002, Bioorganic & medicinal chemistry letters.

The reaction of o-amino aryl carboxylic acids with Grignard reagents. The unusual effect of the N-protecting group on aryl ketone formation

Eugene A. Terefenko, Puwen Zhang, E. Terefenko, 2001 .

Regiospecific bromination of 3-methylindoles with N-bromosuccinimide

J. Cook, Puwen Zhang, Ruiyan Liu, 1995 .

Syntheses of 5-thienyl and 5-furyl-substituted benzodiazepines: probes of the pharmacophore for benzodiazepine receptor agonists

P. Skolnick, Weijiang Zhang, K. Koehler, 1995 .

SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists.

R. Winneker, Eugene A. Terefenko, J. Wrobel, 2007, Bioorganic & Medicinal Chemistry Letters.

Novel pyrrole-containing progesterone receptor modulators.

R. Winneker, M. Collins, J. Wrobel, 2004, Bioorganic & medicinal chemistry letters.

6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.

R. Winneker, S. Lundeen, Eugene A. Terefenko, 2002, Journal of medicinal chemistry.

A successful acid promoted asymmetric pictet-spengler reaction of Na-BOC protected tryptophans. Effect of the BOC group on reactivity and stereoselectivity

J. Cook, Puwen Zhang, 1995 .

SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists.

R. Winneker, J. Wrobel, Zhiming Zhang, 2005, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.

D. Deecher, E. Trybulski, G. Whiteside, 2010, Bioorganic & medicinal chemistry letters.

A concise synthesis of optically active 2-bromotryptophan amino acids present in konbamide and jaspamide via a regiospecific bromination procedure

J. Cook, Puwen Zhang, Ruiyan Liu, 1995 .

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).

L. Leventhal, D. Deecher, E. Trybulski, 2010, Journal of medicinal chemistry.

Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.

K. Burroughs, D. Deecher, P. Mahaney, 2009, Bioorganic & medicinal chemistry letters.

Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis

R. Liu, Yujie Zhang, Yulin Zhao, 2020, Journal of Cancer.

3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.

D. Deecher, P. Mahaney, E. Trybulski, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.

E. Koury, D. Deecher, P. Mahaney, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.

E. Koury, D. Deecher, P. Mahaney, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.

L. Leventhal, P. Mahaney, E. Trybulski, 2006, Bioorganic & medicinal chemistry.

Non-steroidal progesterone receptor modulators

R. Winneker, J. Wrobel, Zhiming Zhang, 2003 .

5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist.

Raymond J. Unwalla, R. Winneker, E. Trybulski, 2007, Bioorganic & medicinal chemistry.

A new generation of progesterone receptor modulators

R. Winneker, C. McComas, M. Yudt, 2008, Steroids.

Molecular and Pharmacological Properties of a Potent and Selective Novel Nonsteroidal Progesterone Receptor Agonist Tanaproget*

C. Lyttle, R. Winneker, Jeff Cohen, 2005, Journal of Biological Chemistry.

Novel 5-aryl-1,3-dihydro-indole-2-thiones. potent, orally active progesterone receptor agonists.

R. Winneker, S. Lundeen, J. Wrobel, 2003, Bioorganic & medicinal chemistry letters.

New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.

R. Winneker, M. Collins, J. Wrobel, 2002, Bioorganic & medicinal chemistry letters.

Overexpressed circRANBP17 acts as an oncogene to facilitate nasopharyngeal carcinoma via the miR-635/RUNX2 axis

R. Liu, Yujie Zhang, Yulin Zhao, 2021, Journal of Cancer.

Nonsteroidal progesterone receptor modulators: structure activity relationships.

R. Winneker, J. Wrobel, Zhiming Zhang, 2005, Seminars in reproductive medicine.

7-aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists.

R. Winneker, J. Wrobel, T. Berrodin, 2008, Bioorganic & medicinal chemistry.

1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists.

R. Winneker, E. Trybulski, T. Berrodin, 2010, Bioorganic & medicinal chemistry letters.

5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators.

R. Winneker, E. Trybulski, T. Berrodin, 2009, Bioorganic & medicinal chemistry letters.

1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.

Raymond J. Unwalla, R. Winneker, J. Wrobel, 2008, Bioorganic & medicinal chemistry letters.

Enantiospecific Synthesis of 5-Methoxy-D(+)- OR L(-) Tryptophan

J. Cook, Puwen Zhang, 1995 .

An enantiospecific synthesis of L(−)- and D(+)-6-Chloro-5-hydroxytryptophan: an unusual amino acid residue from the cyclic hexapeptide keramamide a

J. Cook, Puwen Zhang, Ruiyan Liu, 1995 .

Development of a comprehensive pharmacophore model for the benzodiazepine receptor.

K. Koehler, J. Cook, W. Zhang, 1995, Drug design and discovery.

1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.

D. Deecher, P. Mahaney, E. Trybulski, 2009, Journal of medicinal chemistry.

Syntheses of 5-Thienyl- and 5-Furyl-Substituted Benzodiazepines: Probes of the Pharmacophore for Benzodiazepine Receptor Agonists.

P. Skolnick, Weijiang Zhang, K. Koehler, 1995 .

Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.

P. Skolnick, J. Cook, B. Harris, 1995, Journal of medicinal chemistry.

Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.

D. Deecher, P. Mahaney, E. Trybulski, 2008, Bioorganic & Medicinal Chemistry Letters.

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones.

Z. Zhang, P. Zhang, Eugene A. Terefenko, 2001, Bioorganic & medicinal chemistry letters.