J. Hanselman

发表

Complementary low-density lipoprotein-cholesterol lowering and pharmacokinetics of adding bempedoic acid (ETC-1002) to high-dose atorvastatin background therapy in hypercholesterolemic patients: A randomized placebo-controlled trial.

N. Lalwani, C. T. Cramer, L. Sterling, 2019, Journal of clinical lipidology.

Elevated hepatic apolipoprotein A-I transcription is associated with diet-induced hyperalphalipoproteinemia in rabbits.

D. A. Schwab, B. R. Krause, T. Rea, 2000, Life sciences.

Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.

B. Tait, M. Kowala, G. Lu, 2007, Bioorganic & medicinal chemistry letters.

Effect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins

C. Ballantyne, J. Plutzky, H. Bays, 2021, American journal of preventive cardiology.

Expression of the mRNA encoding truncated PPARα does not correlate with hepatic insensitivity to peroxisome proliferators

B. Koester, T. Rea, M. Pape, 2004, Molecular and Cellular Biochemistry.

A cDNA-dependent scintillation proximity assay for quantifying apolipoprotein A-I.

D. A. Schwab, T. Rea, M. Pape, 1997, Journal of lipid research.

Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.

G. Lu, J. Pfefferkorn, Chulho Choi, 2007, Bioorganic & medicinal chemistry.

Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic Mbtps1 Mutation in Mice

B. Beutler, E. Moresco, Xiaohong Li, 2012, G3: Genes | Genomes | Genetics.

Effect of ETC-1002 on Serum Low-Density Lipoprotein Cholesterol in Hypercholesterolemic Patients Receiving Statin Therapy.

J. Mckenney, C. Ballantyne, N. Lalwani, 2016, The American journal of cardiology.

Abstract 17499: ETC-1002 Incrementally Lowers Low Density Lipoprotein-cholesterol in Patients With Hypercholesterolemia Receiving Stable Statin Therapy

C. Ballantyne, N. Lalwani, D. Macdougall, 2015 .

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.

G. Lu, J. Pfefferkorn, M. Harris, 2007, Bioorganic & medicinal chemistry letters.

Inhibition of Sphingomyelin Synthesis Reduces Atherogenesis in Apolipoprotein E–Knockout Mice

M. Rekhter, R. Panek, S. Karathanasis, 2004, Circulation.

Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.

Yuntao Song, Bruce Auerbach, Lisa Dillon, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.

Bo Feng, David B Duignan, Bruce Auerbach, 2011, Bioorganic & medicinal chemistry letters.

Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.

Yuntao Song, Bruce Auerbach, Lisa Dillon, 2008, Bioorganic & medicinal chemistry letters.

Combination of bempedoic acid, ezetimibe, and atorvastatin in patients with hypercholesterolemia: A randomized clinical trial.

S. Nicholls, D. Macdougall, L. Sterling, 2020, Atherosclerosis.

Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial.

Lawrence A Leiter, A. Goldberg, E. Stroes, 2019, JAMA.

Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus

M. Milad, D. Macdougall, P. Strange, 2014, Arteriosclerosis, thrombosis, and vascular biology.

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

Stephen L. Pinkosky, R. Newton, J. Hanselman, 2012, Journal of Lipid Research.

Efficacy and safety of bempedoic acid in women with hypercholesterolemia: Pooled analyses from phase 3 trials

Lawrence A Leiter, A. Goldberg, A. Catapano, 2023, medRxiv.

Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: A post hoc analysis of efficacy and glycaemic control using pooled data from phase 3 clinical trials

Lawrence A Leiter, A. Gotto, M. Banach, 2022, Diabetes, obesity & metabolism.

Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study.

Lawrence A Leiter, M. Banach, C. Ballantyne, 2018, Atherosclerosis.

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

R. Lister, Stephen L. Pinkosky, R. Newton, 2013, Journal of Lipid Research.

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism[S]

Khosrow Adeli, Sergey Filippov, K. Adeli, 2013, Journal of Lipid Research.

Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.

M. Rekhter, R. Panek, S. Karathanasis, 2006, Atherosclerosis.

Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance.

J. Mckenney, P. Thompson, C. Ballantyne, 2016, Journal of clinical lipidology.

Efficacy and Safety of Triplet Therapy With Bempedoic Acid, Ezetimibe, and Atorvastatin in Patients with Hypercholesterolemia

S. Nicholls, D. Macdougall, L. Sterling, 2019, Journal of Clinical Lipidology.

Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.

Bruce Auerbach, Lisa Dillon, Jeffrey A Pfefferkorn, 2008, Journal of medicinal chemistry.

Evaluation of the efficacy and safety of bempedoic acid in women and men: Pooled analyses from phase 3 trials.

Lawrence A Leiter, M. Banach, A. Goldberg, 2023, Atherosclerosis.

Atherosclerosis in Octodon degus (degu) as a model for human disease.

Stephen L. Pinkosky, P. Lester, R. Homan, 2010, Atherosclerosis.