J. Wemer

发表

NXY‐059 Does Not Affect Bleeding Time in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled, 3‐Period Crossover Phase I Study

S. Schulman, N. Egberg, G. Englund, 2007, Journal of clinical pharmacology.

Active Renal Secretion of NXY‐059, a Novel Neuroprotectant, Is Mediated via an Organic Acid Transporter

O. Borgå, D. Nilsson, Yi-fang Cheng, 2007, Journal of clinical pharmacology.

Comparison between electrically evoked and potassium-induced 3H-noradrenaline release from rat neocortex slices: Role of calcium ions and transmitter pools

A. Schoffelmeer, A. H. Mulder, J. Wemer, 1981, Neurochemistry International.

The prevalence of CYP2D6 and CYP2C19 genotypes in a population of healthy Dutch volunteers

R. A. Zeeuw, J. Jonkman, J. Jonkman, 2001, European Journal of Clinical Pharmacology.

Septic shock: no correlation between plasma levels of nitric oxide metabolites and hypotension or lethality.

A. Bisschop, J. Piet, D. D. de Wildt, 1994, European journal of pharmacology.

Blood Coagulation , Fibrinolysis and Cellular Haemostasis Phase I study of Solulin , a novel recombinant soluble human thrombomodulin analogue

P. Giesen, Thijs MP van Iersel, H. Stroissnig, 2018 .

In vitro method for measurement of cardiac performance and responses to inotropic drugs after experimentally induced myocardial infarction in the rat.

A. Porsius, W. Vleeming, P. A. van der Wouw, 1989, Journal of pharmacological methods.

Modulation by pertussis toxin of salbutamol- and arecoline-induced effects in the isolated heart and aorta of the rat.

A. Porsius, J. Riezebos, D. D. de Wildt, 1993, European journal of pharmacology.

An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19

J. Jonkman, B. Oosterhuis, R. D. de Zeeuw, 2001, European Journal of Clinical Pharmacology.

Troglitazone has no effect on red cell mass or other erythropoietic parameters

L. Squassante, P. Dogterom, J. Jonkman, 1999, European Journal of Clinical Pharmacology.

CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences

R. A. Zeeuw, B. Wilffert, J. Wieling, 1999, European Journal of Clinical Pharmacology.

Cyclic-AMP mediated drugs: differential or global reduction of eicosanoid synthesis in the isolated rat lung?

A. Porsius, F. Zijlstra, M. Post, 1992, Mediators of inflammation.

Functional characterization of the muscarinic receptor in rat lungs.

A. Porsius, M. Post, J. T. te Biesebeek, 1991, European journal of pharmacology.

The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers.

D. Smith, E. Seaber, J. V. van Lier, 1998, British journal of clinical pharmacology.

Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: role of arachidonic acid metabolites.

A. Porsius, M. Post, J. Riezebos, 1997, Journal of cardiovascular pharmacology.

Plasma elimination of milrinone in rats in relation to its hemodynamic effects.

A. Porsius, W. Vleeming, J. Wemer, 1990, Journal of pharmaceutical sciences.

The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age.

J. W. van der Laan, J. T. te Biesebeek, D. D. de Wildt, 1998, Vaccine.

A Comparison of the Pharmacokinetics and Tolerability of Riluzole after Repeat Dose Administration in Healthy Elderly and Young Volunteers

G. Montay, J. Gautier, P. Peeters, 1999, Journal of clinical pharmacology.

Role of lipoxygenase products in the effects of angiotensin II in the isolated aorta and perfused heart of the rat

A. Porsius, M. Post, W. Vleeming, 1995, Mediators of inflammation.

Pharmacological characterization of presynaptic alpha-adrenoceptors in the nucleus tractus solitarii and the cerebral cortex of the rat

A. H. Mulder, J. Wemer, A. L. Frankhuyzen, 1982, Neuropharmacology.

IN VITRO STUDIES ON PRESYNAPTIC ALPHA-RECEPTOR MEDIATED MODULATION OF TRANSMITTER RELEASE FROM CENTRAL NORADRENERGIC NEURONS

K. Dismukes, A. H. Mulder, C. D. Langen, 1979 .

Delayed antibiotic-induced lysis of Escherichia coli in vitro is correlated with enhancement of LPS release.

A. D. de Neeling, D. D. de Wildt, C. van den Berg, 1992, Scandinavian journal of infectious diseases.

Comparison of the antiatherogenic effects of isradipine and ramipril in cholesterol-fed rabbits: I. Effect on progression of atherosclerosis and endothelial dysfunction.

G. Meijer, A. Porsius, R. Beems, 1994, Journal of cardiovascular pharmacology.

On the capacity of presynaptic alpha receptors to modulate norepinephrine release from slices of rat neocortex and the affinity of some agonists and antagonists for these receptors.

C. D. de Langen, A. H. Mulder, J. V. D. van der Lugt, 1979, The Journal of pharmacology and experimental therapeutics.

The Mechanism of Fluoride-Induced Hypocalcaemia

J. Meulenbelt, H. Vaessen, D. D. de Wildt, 1994, Human & experimental toxicology.

Postnatal development of presynaptic alpha-adrenoceptors in rat cerebral cortex: studies with brain slices and synaptosomes

J. Wemer, H. MulderArie, 1981, Brain Research.

Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra-individual reproducibility and occurrence of adverse events.

D. Touw, J. Wieling, J. Jonkman, 2001, British journal of clinical pharmacology.

Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results.

R. Schmouder, C. Emotte, A. Jakab, 2012, International journal of clinical pharmacology and therapeutics.

Experimental study of the detrimental effect of dopamine/glucagon combination in d,l- propranolol intoxication

J. Meulenbelt, W. Vleeming, J. Wemer, 1996, Human & experimental toxicology.

Reduced survival after isoprenaline/ dopamine in d,l-propranolol intoxicated rats

J. Meulenbelt, W. Vleeming, J. Wemer, 1996, Human & experimental toxicology.

Toxic doses of rac-, (-)-(S)- and (+)-(R)-propranolol in rats and rabbits.

J. Meulenbelt, W. Bode, D. D. de Wildt, 1996, Chirality.

Toxicokinetics of a single intravenous dose of rac-propranolol versus optically pure propranolol in the rat.

K. Groen, W. Bode, D. D. de Wildt, 1995, Chirality.

Modulation of histamine release by rat peritoneal mast cells in a superfusion set-up

A. Porsius, M. Post, J. Wemer, 1990, Agents and Actions.

AS A PROBE FOR THE CYP 2 C 19 ACTIVITY : A CRITICAL EVALUATION OF ITS APPLICABILITY IN EPIDEMIOLOGY AND CLINICAL PHARMACOLOGY

R. A. Zeeuw, B. Wilffert, D. Touw, 2018 .

2.1 MEPHENYTOIN AS A PROBE FOR THE CYP2C19 ACTIVITY: A CRITICAL EVALUATION OF ITS APPLICABILITY IN EPIDEMIOLOGY AND CLINICAL PHARMACOLOGY

R. A. Zeeuw, B. Wilffert, D. Touw, 2001 .

Safety, tolerability and pharmacokinetics of escalating doses of NXY-059 in healthy young and elderly subjects*

S. Schulman, L. Nyman, S. Björck, 2006, Current medical research and opinion.

Systemic Fluoride Poisoning Following Dermal Hydrofluoric ACID Exposure: Development of an Intravenous Sodium Fluoride Infusion Model in Rats

J. Meulenbelt, D. J. Wildt, P. Dortant, 1995 .

PART III APPLICATION IN EPIDEMIOLOGY 3 . 1 CYP 2 D 6 AND CYP 2 C 19 ACTIVITY IN A LARGE POPULATION OF DUTCH HEALTHY VOLUNTEERS : INDICATIONS FOR ORAL CONTRACEPTIVE-RELATED GENDER DIFFERENCES

R. A. Zeeuw, B. Wilffert, J. Wieling, 2018 .

Clinical and Bioanalytical Evaluation of Dried Blood spot Sampling for Genotyping and Phenotyping of Cytochrome p450 Enzymes in Healthy Volunteers

J. Wieling, T. Boer, J. Wemer, 2014 .

Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers.

Erik A. Meulman, T. de Boer, J. Wieling, 2011, Biomedical chromatography : BMC.

Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study

R. A. Zeeuw, A. Boer, L. Leij, 2003, European Journal of Clinical Pharmacology.

Time Course of Endothelial Dysfunction in Experimental Atherosclerosis in the Rabbit

A. Porsius, R. Beems, G. Speijers, 1993 .

Cardiovascular responses to milrinone in pertussis toxin-pretreated pithed rats.

A. Porsius, D. D. de Wildt, J. Wemer, 1990, European journal of pharmacology.

Positive inotropic effects of milrinone, sulmazole and AR-L100 on isolated normal and infarcted hearts of the rat.

A. Porsius, W. Vleeming, J. Wemer, 1989, Archives internationales de pharmacodynamie et de therapie.

Tetrahydrobiopterin induces vasodilation via enhancement of cGMP level.

J. van Amsterdam, J. Wemer, 1992, European journal of pharmacology.

Comparison of equilibrium dialysis, ultrafiltration, and gel permeation chromatography for the determination of free fractions of phenobarbital and phenytoin.

G. H. Faber, J. Wemer, D. Faber, 1985, Journal of pharmaceutical sciences.

Pharmacokinetic-pharmacodynamic modelling of oxprenolol in man using continuous non-invasive blood pressure monitoring

J. Karemaker, R. Koopmans, C. Boxtel, 2004, European Journal of Clinical Pharmacology.

Abstracts of papers Pharmacological meeting

N. Ramsey, J. M. Ree, M. Danhof, 1985, Pharmaceutisch Weekblad.

On the modulating effects of temperature, albumin, pH and calcium on the free fractions of phenobarbitone and phenytoin

J. Wemer, D. Faber, J. W. Melten, 1986, The Journal of pharmacy and pharmacology.

Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate–antacid formulation (Gaviscon Double Action)

C. Coyle, J. Wemer, M. van Haastert, 2018, Drug development and industrial pharmacy.

Studies on the role of Na+, K+ and Cl− ion permeabilities in K+-induced release of 3H-noradrenaline from rat brain slices and synaptosomes and in its presynaptic α-adrenergic modulation

A. Schoffelmeer, A. H. Mulder, J. Wemer, 1981, Naunyn-Schmiedeberg's Archives of Pharmacology.

Comparison of the antiatherogenic effects of isradipine and ramipril in cholesterol-fed rabbits: II. Effect on regression of atherosclerosis and restoration of endothelial function.

G. Meijer, A. Porsius, R. Beems, 1994, Journal of cardiovascular pharmacology.

Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

M. Struys, A. Absalom, Khalid Abou Farha, 2013, European Journal of Clinical Pharmacology.

The effect of oxprenolol dosage time on its pharmacokinetics and haemodynamic effects during exercise in man

J. Karemaker, R. Koopmans, C. Boxtel, 2004, European Journal of Clinical Pharmacology.

Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening.

J. Wieling, J. Jonkman, J. Jonkman, 2000, Therapeutic drug monitoring.

NXY‐059 Does Not Significantly Interact With Furosemide in Healthy Volunteers

A. Grahnén, O. Borgå, D. Nilsson, 2006, Journal of clinical pharmacology.

Effects of milrinone, sulmazole and theophylline on adenosine enhancement of antigen-induced bronchoconstriction and mediator release in rat isolated lungs.

A. Porsius, M. Post, J. T. te Biesebeek, 1991, Pulmonary pharmacology.