Mahmood Haj-Yahya

发表

Structural basis for histone H2B deubiquitination by the SAGA DUB module

A. Brik, C. Wolberger, A. Ringel, 2016, Science.

Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated α-synuclein.

H. Lashuel, A. Brik, K. S. A. Kumar, 2011, Angewandte Chemie.

RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation.

E. Domany, J. Hanna, M. Oren, 2012, Molecular cell.

Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

A. Ciechanover, H. Lashuel, A. Brik, 2013, Proceedings of the National Academy of Sciences.

Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

H. Lashuel, M. Diamond, K. Rajasekhar, 2020, Angewandte Chemie.

Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding†

H. Lashuel, M. Diamond, K. Rajasekhar, 2019, Angewandte Chemie.

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States.

H. Lashuel, Mahmood Haj-Yahya, 2018, Journal of the American Chemical Society.

N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester.

P. Dawson, A. Brik, K. S. A. Kumar, 2010, Organic & biomolecular chemistry.

Protecting group variations of delta-mercaptolysine useful in chemical ubiquitylation.

A. Brik, Mahmood Haj-Yahya, Lesly A Erlich, 2010, Biopolymers.

Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins.

A. Ciechanover, D. Fushman, A. Brik, 2013, Angewandte Chemie.

Site-specific hyperphosphorylation of tau inhibits its fibrillization in vitro, blocks its seeding capacity in cells, and disrupts its microtubule binding; Implications for the native state stabilization of tau

H. Lashuel, M. Diamond, K. Rajasekhar, 2019, bioRxiv.

Side-chain assisted ligation in protein synthesis.

A. Brik, K. S. A. Kumar, Mahmood Haj-Yahya, 2009, Bioorganic & medicinal chemistry letters.

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding

H. Lashuel, C. Becker, Doris Ellmer, 2019, Angewandte Chemie.

Chemical synthesis of ubiquitinated peptides with varying lengths and types of ubiquitin chains to explore the activity of deubiquitinases.

A. Brik, S. Karthikeyan, K. S. A. Kumar, 2012, Angewandte Chemie.

Highly efficient and chemoselective peptide ubiquitylation.

H. Lashuel, A. Brik, Mahmood Haj-Yahya, 2009, Angewandte Chemie.

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.

A. Ciechanover, O. Lewinson, H. Lashuel, 2012, Molecular cell.

The U4/U6 Recycling Factor SART3 Has Histone Chaperone Activity and Associates with USP15 to Regulate H2B Deubiquitination*

A. Brik, T. Yao, Dongmei Cheng, 2014, The Journal of Biological Chemistry.

Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

H. Urlaub, M. Oren, A. Brik, 2013, Cell reports.

N-methylation of isopeptide bond as a strategy to resist deubiquitinases.

M. Oren, A. Brik, Efrat Shema, 2012, Angewandte Chemie.

Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

H. Urlaub, M. Oren, A. Brik, 2013, Cell Reports.

N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester.

A. Brik, Mahmood Haj-Yahya, Lesly A Erlich, 2010, Organic & biomolecular chemistry.

N-methylation of isopeptide bond as a strategy to resist deubiquitinases.

M. Oren, A. Brik, Mahmood Haj-Yahya, 2012, Angewandte Chemie.