A. Jobson

发表

X‐ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper‐dependent hydrophobic pocket

Y. Pommier, R. Shoemaker, J. Tropea, 2011, FEBS letters.

Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases

M. Tilby, P. Charlton, P. Mistry, 2009, Cancer Chemotherapy and Pharmacology.

Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.

Y. Pommier, R. Shoemaker, J. Tropea, 2011, Journal of structural biology.

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]

Y. Pommier, A. Monks, R. Shoemaker, 2009, Journal of Pharmacology and Experimental Therapeutics.

Identification of a Bis-guanylhydrazone [4,4′-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase

D. Scudiero, Y. Pommier, R. Shoemaker, 2007, Molecular Pharmacology.

Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor

Yves Pommier, Y. Pommier, R. Shoemaker, 2008, Protein science : a publication of the Protein Society.

Repair of topoisomerase I-mediated DNA damage.

Y. Pommier, Z. Miao, C. Redon, 2006, Progress in nucleic acid research and molecular biology.

Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.

M. López-Lázaro, H. Curtis, K. Gilroy, 2007, Journal of natural products.

Inhibition of Human Tyrosyl-DNA Phosphodiesterase by Aminoglycoside Antibiotics and Ribosome Inhibitors

Yves Pommier, Zhiyong Liao, Y. Pommier, 2006, Molecular Pharmacology.

Identification of a bis-guanylhydrazone ( NSC 109555 ) as a novel chemotype for inhibition of Chk 2 kinase

D. Scudiero, Y. Pommier, R. Shoemaker, 2007 .

Detection of in vitro kinase generated protein phosphorylation sites using gamma[18O4]-ATP and mass spectrometry.

Y. Pommier, T. Veenstra, Ming Zhou, 2007, Analytical Chemistry.

Abstract A120: Cellular inhibition of Chk2 kinase and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019

Y. Pommier, A. Monks, R. Shoemaker, 2009 .

Cellular inhibition of Chk 2 kinase and potentiation of camptothecins and radiation by the novel Chk 2 inhibitor PV 1019

Y. Pommier, A. Monks, R. Shoemaker, 2009 .