R. Doveston

发表

A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids.

Adam Nelson, Daniel J Foley, S. Marsden, 2015, Chemical communications.

A Systematic Approach to Diverse, Lead‐Like Scaffolds from α,α‐Disubstituted Amino Acids.

S. Marsden, Daniel J. Foley, A. Nelson, 2015 .

A unified lead-oriented synthesis of over fifty molecular scaffolds.

Adam Nelson, Mark Dow, David House, 2015, Organic & biomolecular chemistry.

Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks

Adam Nelson, Frank von Delft, Daniel J Foley, 2017, Chemistry.

Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

L. Brunsveld, F. Meijer, R. Doveston, 2020, ChemMedChem.

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

C. Ottmann, M. Scheepstra, L. Brunsveld, 2019, Journal of medicinal chemistry.

Discovering protein–protein interaction stabilisers by native mass spectrometry

Aneika C. Leney, J. Basran, Jeddidiah Bellamy‐Carter, 2021, Chemical science.

Small‐molecule stabilization of the p53 – 14‐3‐3 protein‐protein interaction

C. Ottmann, Qing Cao, L. Brunsveld, 2017, FEBS letters.

Fragment-based Differential Targeting of PPI Stabilizer Interfaces

C. Ottmann, I. Landrieu, Qing Cao, 2020, Journal of medicinal chemistry.

Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt

L. Brunsveld, F. Meijer, I. A. Leijten-van de Gevel, 2021, Proceedings of the National Academy of Sciences.

Contemporary biophysical approaches for studying 14-3-3 protein-protein interactions

A. J. Hudson, R. Doveston, Bethany Thurairajah, 2022, Frontiers in Molecular Biosciences.

Cooperative stabilisation of 14-3-3σ protein–protein interactions via covalent protein modification

P. Roversi, J. Ward, S. Macip, 2021, Chemical science.

Total synthesis of an oxepine natural product, (±)-janoxepin.

S. Jones, R. Doveston, R. Steendam, 2012, Organic letters.

An expedient synthesis of the proposed biosynthetic precursor of the oxepine natural product, janoxepin

R. Doveston, R. Taylor, 2012 .

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool.

Adam Nelson, Ignacio Colomer, Christopher J. Empson, 2016, Chemical communications.

Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ.

C. Ottmann, I. Landrieu, M. Ehrmann, 2019, ACS chemical biology.

Regulation of p53 by the 14-3-3 protein interaction network: new opportunities for drug discovery in cancer

J. Ward, S. Macip, R. Doveston, 2020, Cell death discovery.

Modulators of 14-3-3 Protein–Protein Interactions

L. M. Stevers, M. Hann, C. Ottmann, 2017, Journal of medicinal chemistry.

Stabilization of protein-protein interactions in drug discovery

Michael Hann, Matthew W D Perry, Christian Ottmann, 2017, Expert opinion on drug discovery.

Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt

C. Ottmann, B. Klebl, L. Brunsveld, 2021, Journal of medicinal chemistry.

Structural interface between LRRK2 and 14-3-3 protein.

Christian Ottmann, L. M. Stevers, Luc Brunsveld, 2017, The Biochemical journal.

Towards the realisation of lead-oriented synthesis.

Adam Nelson, Richard Doveston, Stephen Marsden, 2014, Drug discovery today.

Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site

L. Brunsveld, F. Meijer, Maxime C. M. van den Oetelaar, 2021, ACS medicinal chemistry letters.