S. Ko

发表

Design and synthesis of potential DNA cross-linking reagents based on the anthramycin class of minor groove binding compounds

P. Confalone, G. M. Cole, E. Huie, 1988 .

Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.

G. Trainor, M. Covington, C. Decicco, 2005, Journal of medicinal chemistry.

CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.

I. Kariv, K. Vaddi, M. Covington, 2007, Bioorganic & medicinal chemistry letters.

Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate.

R. Magolda, J. Trzăskos, B. Larsen, 1991, The Journal of biological chemistry.

Effects of 15-oxa-32-vinyl-lanost-8-ene-3 beta,32 diol on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and low density lipoprotein receptor in rat liver.

J. Trzăskos, G. Ness, C. Chambers, 1998, Archives of biochemistry and biophysics.

Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation

K. McIntyre, S. Mandlekar, J. Trzăskos, 2006, Journal of Pharmacology and Experimental Therapeutics.

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.

G. Trainor, M. Covington, C. Decicco, 2002, Bioorganic & medicinal chemistry letters.

Model studies for the total synthesis of the maytansinoids based on the intramolecular nitrile oxide-olefin [3+2] cycloaddition reaction

P. Confalone, S. Ko, 1985 .

The intramolecular nitrile oxide-olefin [3+2] cycloaddition route to the maytansinoids

P. Confalone, S. Ko, 1984 .

Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CCR3 Antagonists in Mouse Models of Allergic Inflammation

K. McIntyre, S. Mandlekar, J. Trzăskos, 2006 .

2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.

G. Trainor, M. Covington, C. Decicco, 2006, Bioorganic & medicinal chemistry letters.

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.

G. Trainor, M. Covington, C. Decicco, 2004, Bioorganic & medicinal chemistry letters.

Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.

Michael A. Galella, K. McIntyre, J. Barrish, 2020, ACS medicinal chemistry letters.

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVATM)

G. Trainor, R. Klabe, S. Erickson-Viitanen, 1999 .

Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.

S Diamond, S S Ko, G L Trainor, 2000, Journal of medicinal chemistry.

Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors

G. Trainor, S. P. Seitz, A. Srivastava, 1999 .

Synthetic studies on palytoxin. Stereocontrolled, practical synthesis of the C.101-C.115 segment

Y. Kishi, L. L. Klein, S. Ko, 1983 .

Stereocontrolled synthesis of D-pentitols, 2-amino-2-deoxy-D-pentitols and 2-deoxy-D-pentitols from D-glyceraldehyde acetonide

Y. Kishi, S. Ko, N. Minami, 1982 .

Synthesis and evaluation of efavirenz (Sustiva) analogues as HIV-1 reverse transcriptase inhibitors: replacement of the cyclopropylacetylene side chain.

L. Bacheler, G. Trainor, A. Cocuzza, 2001, Bioorganic & medicinal chemistry letters.

Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.

L. Bacheler, G. Trainor, R. Klabe, 1998, Journal of medicinal chemistry.

Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1

Ronald M. Klabe, L. Bacheler, P. Anderson, 1999, Antimicrobial Agents and Chemotherapy.

Stereochemistry of palytoxin. 4. Complete structure

J. M. Finan, Yoshito Kishi, W. Christ, 1982 .

Stereocontrolled synthesis of D-pentitols, 2-amino-2-deoxy-D-pentitols and 2-deoxy-D-pentitols from D-glyceraldehyde acetonide

Y. Kishi, S. Ko, N. Minami, 1982 .

ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes.

J. Billheimer, P. Meunier, R. Wexler, 1996, Bioorganic & medicinal chemistry.

Stereochemical control in the intramolecular Diels-Alder reaction. 2. Structural and electronic effects on reactivity and selectivity

R. K. Boeckman, S. Ko, 1982 .

Enantioselective synthesis of benzyl (1S,2R,4R)-4-(tert-butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate using an iodolactamization as the key step.

P. Carter, M. Voss, R. Cherney, 2009, The Journal of organic chemistry.

Stereochemical control in the intramolecular Diels-Alder reaction. 2. Structural and electronic effects on reactivity and selectivity

R. K. Boeckman, S. Ko, 1982 .

Stereochemistry of palytoxin. Part 1. C85-C115 segment

Y. Kishi, D. Uemura, L. L. Klein, 1982 .

Stereochemistry of palytoxin. Part 2. C1-C6, C47-C74, and C77-C83 segments

J. M. Finan, Y. Kishi, D. Uemura, 1982 .

Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: I. Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties.

S S Ko, M. Favata, R. Magolda, 1995, Biochemistry.

Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis.

M. Favata, R. Magolda, J. Trzăskos, 1993, The Journal of biological chemistry.

Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.

D. J. Nelson, J. Barrish, S. Mandlekar, 2015, ACS medicinal chemistry letters.

Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.

G. Trainor, M. Covington, C. Decicco, 2004, Bioorganic & medicinal chemistry letters.

Cyclic derivatives as modulators of chemokine receptor

Michael G. Yang, A. Srivastava, P. Carter, 2004 .

STEREOCHEMISTRY OF PALYTOXIN. PART 4. COMPLETE STRUCTURE

J. M. Finan, W. Christ, Y. Kishi, 1983 .

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.

I. Kariv, S. Mandlekar, A. Tebben, 2008, Bioorganic & medicinal chemistry letters.

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists.

A. Tebben, P. Carter, J. Duncia, 2008, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.

G. Trainor, M. Covington, C. Decicco, 2002, Journal of medicinal chemistry.

Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.

L. Bacheler, R. Klabe, J. Rodgers, 1999, Bioorganic & medicinal chemistry letters.

Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.

K. McIntyre, D. Shuster, D. Shen, 2016, Journal of medicinal chemistry.

4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.

L. Bacheler, C. Weigelt, A. Cocuzza, 2001, Bioorganic & medicinal chemistry letters.

Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.

Michael G. Yang, Michael A. Galella, J. Barrish, 2019, ACS medicinal chemistry letters.

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).

G. Trainor, R. Klabe, S. Erickson-Viitanen, 1999, Bioorganic & medicinal chemistry letters.