M. Cardozo

发表

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.

G. Poncet-Montange, Gilbert R. Lee, J. Ladbury, 2015, The Biochemical journal.

1,3‐Dipolar cycloaddition reactions. Regioselective synthesis of heterocycles and theoretical studies

A. B. Pierini, M. T. Pizzorno, M. Cardozo, 1989 .

Significance Analysis and Multiple Pharmacophore Models for Differentiating P-Glycoprotein Substrates.

X. Ling, J. Eksterowicz, Leping Li, 2008 .

Mutational analysis of G-protein coupled receptor--FFA2.

R. Lindberg, Yang Li, R. Schwandner, 2011, Biochemical and biophysical research communications.

A novel series of IKKβ inhibitors part II: description of a potent and pharmacologically active series of analogs.

N. Walker, R. C. Hawley, C. Broka, 2011, Bioorganic & medicinal chemistry letters.

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

C. Rudin, Jason P. Burke, C. Bristow, 2020, Journal of medicinal chemistry.

Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors

D. Whittington, Yi Chen, K. Miner, 2012 .

Preliminary structural analysis of the mutations selected by non-nucleoside inhibitors of HIV-1 reverse transcriptase

L. Tong, J. Adams, Paul-James Jones, 1993 .

Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand.

G. Nabozny, Ljiljana Žuvela-Jelaska, D. Kuzmich, 2005, Bioorganic & medicinal chemistry letters.

Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.

Sean P. Brown, A. Cheng, D. Whittington, 2019, Journal of medicinal chemistry.

Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quino

J. McCarter, D. Whittington, Iain D. G. Campuzano, 2016, Journal of medicinal chemistry.

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

Kathleen A. Boyle, Anjanabha Saha, J. Kuriyan, 2019, Nature Communications.

Synthesis and SAR study of potent and selective PI3Kδ inhibitors.

J. McCarter, D. Metz, S. Wong, 2015, Bioorganic & medicinal chemistry letters.

Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-Substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes.

J. Proudfoot, L. Tong, U. Patel, 1995, Journal of medicinal chemistry.

Discovery and in vivo evaluation of dual PI3Kβ/δ inhibitors.

D. Whittington, Yi Chen, K. Miner, 2012, Journal of medicinal chemistry.

Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5. 4-Substituted and 2,4-disubstituted analogs of nevirapine.

J. Proudfoot, P. Grob, U. Patel, 1995, Journal of medicinal chemistry.

Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase.

J. Peterson, N. Moss, S. Lukas, 2002, Journal of medicinal chemistry.

Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase.

J. Peterson, S. Pav, N. Moss, 2003, Journal of medicinal chemistry.

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.

N. Walker, Zhulun Wang, Jinsong Liu, 2012, Bioorganic & medicinal chemistry letters.

The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.

N. Walker, Zhulun Wang, Jinsong Liu, 2010, Bioorganic & medicinal chemistry letters.

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

N. Walker, Zhulun Wang, Haoda Xu, 2012, Journal of medicinal chemistry.

Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.

J. McCarter, D. Whittington, D. Metz, 2016, Journal of medicinal chemistry.

Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.

Xiaolin Hao, Ben Fisher, Andreas Reichelt, 2015, Journal of medicinal chemistry.

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

Kathleen A. Boyle, Anjanabha Saha, J. Kuriyan, 2019, Nature Communications.

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.

Sean P. Brown, Nick A. Paras, L. Poppe, 2018, Cancer discovery.

Identification of potent and selective MTH1 inhibitors.

F. Mseeh, C. Toniatti, G. Draetta, 2005, Bioorganic & medicinal chemistry letters.

Thermodynamic analysis of mRNA cap binding by the human initiation factor eIF4E via free energy perturbations.

N. Walker, S. Thibault, J. Mihalic, 2009, Journal of the American Chemical Society.

MM-GB/SA Rescoring of Docking Poses in Structure-Based Lead Optimization

Cristiano Ruch Werneck Guimarães, Mario G. Cardozo, M. Cardozo, 2008, J. Chem. Inf. Model..

Structure guided design of a series of sphingosine kinase (SphK) inhibitors.

Holger Wesche, Frank Kayser, Alan C Cheng, 2013, Bioorganic & medicinal chemistry letters.

Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase

Mario G. Cardozo, A. J. Hopfinger, Takatoshi Kawai, 1992 .

A model for the dynemicin‐A cleavage of DNA using molecular dynamics simulation

A. Hopfinger, M. Cardozo, 1993, Biopolymers.

5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

P. Coward, M. Véniant, J. Medina, 2016, ACS medicinal chemistry letters.

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

Yang Li, R. Schwandner, J. Liu, 2008, Molecular Pharmacology.

Significance Analysis and Multiple Pharmacophore Models for Differentiating P-Glycoprotein Substrates

Xuefeng Bruce Ling, Mario G. Cardozo, Leping Li, 2007, J. Chem. Inf. Model..

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit.

N. Walker, R. C. Hawley, C. Broka, 2011, Bioorganic & medicinal chemistry letters.

Identification of dissociated non-steroidal glucocorticoid receptor agonists.

J. Proudfoot, P. Reilly, Alison J Kukulka, 2007, Bioorganic & medicinal chemistry letters.

Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction.

L. Frye, D. Jeanfavre, L. Tong, 2001, Journal of the American Chemical Society.

Molecular modelling of ligand–DNA intercalation interactions

A. Hopfinger, M. Cardozo, Y. Kawakami, 1995 .

Discovery of potent and selective PKC-θ inhibitors

Mario G. Cardozo, Mohammed A. Kashem, Carol Ann Homon, 2007 .

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA 2

Yang Li, R. Schwandner, J. Liu, 2008 .

New Methods in Molecular Shape Analysis to Identify and Characterize Active Conformations

M. Koehler, A. Hopfinger, B. Burke, 1992 .

Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).

N. Walker, Zhulun Wang, Jinsong Liu, 2009, Bioorganic & medicinal chemistry letters.

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.

Xiaolin Hao, Holger Wesche, Shou-Hua Xiao, 2008, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective PKC-theta inhibitors.

Mohammed A Kashem, C. Homon, J. Woska, 2007, Bioorganic & medicinal chemistry letters.

Evolution of the Thienopyridine Class of Inhibitors of IκB Kinase-β: Part I: Hit-to-Lead Strategies

C. Homon, C. Cywin, Jiang-Ping Wu, 2006 .

Ligands for the tyrosine kinase p56lck SH2 domain: discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements.

J. Proudfoot, L. Tong, E. Hickey, 1999, Journal of medicinal chemistry.

A Novel Frequency Distribution Selection Method for Efficient Plate Layout of a Diverse Combinatorial Library

Mario G. Cardozo, Edward T. Graham, Stephen P. Jacober, 2001, J. Chem. Inf. Comput. Sci..

Allosteric rescuing of loss‐of‐function FFAR2 mutations

R. Lindberg, Yang Li, R. Schwandner, 2010, FEBS letters.

Identification of potent and selective MTH1 inhibitors.

F. Mseeh, C. Toniatti, G. Draetta, 2005, Bioorganic & Medicinal Chemistry Letters.