Shawn P. Walsh

发表

Diversity-oriented synthesis of polyketide natural products via iterative chemo- and stereoselective functionalization of polyenoates: development of a unified approach for the C(1-19) segments of lituarines A-C.

M. Duffey, Amos B. Smith, Shawn P. Walsh, 2005, Organic letters.

3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.

A. Howard, Carina P. Tan, G. Eiermann, 2011, Bioorganic & medicinal chemistry letters.

Inhibition of ROMK blocks macula densa tubuloglomerular feedback yet causes renal vasoconstriction in anesthetized rats.

W. Welch, C. Wilcox, Xiaoyan Zhou, 2017, American journal of physiology. Renal physiology.

Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.

A. Swensen, G. Kaczorowski, B. Priest, 2016, Bioorganic & medicinal chemistry letters.

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.

J. Metzger, A. Swensen, M. Forrest, 2016, ACS medicinal chemistry letters.

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.

J. Chen, R. Bentley, J. Metzger, 2015, ACS medicinal chemistry letters.

Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats

M. Forrest, Daphne Szeto, Gail Forrest, 2017, Hypertension.

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.

Furoyl and benzofuroyl pyrroloquinolones as potent and selective PDE5 inhibitors for treatment of erectile dysfunction.

Weiqin Jiang, Z. Sui, M. Macielag, 2003, Journal of medicinal chemistry.

Total syntheses of the assigned structures of lituarines B and C.

M. Duffey, Amos B. Smith, K. Basu, 2008, Journal of the American Chemical Society.

Total synthesis of (+)-irciniastatin A (a.k.a. psymberin) and (-)-irciniastatin B.

Jon A. Jurica, Amos B. Smith, Adam T. Hoye, 2013, The Journal of organic chemistry.

Total synthesis of (+)-psymberin (irciniastatin A): catalytic reagent control as the strategic cornerstone.

Jon A. Jurica, Amos B. Smith, Shawn P. Walsh, 2008, Organic letters.

Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.

A. Swensen, G. Kaczorowski, B. Priest, 2013, Bioorganic & medicinal chemistry letters.

Synthesis of cyclophosphamide‐4,4,5,5‐d4

S. Ludeman, L. Anderson, Y. Chang, 1995 .

Rapid development of two factor IXa inhibitors from hit to lead.

W. Greenlee, R. Berger, E. Sherer, 2015, Bioorganic & medicinal chemistry letters.

A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives

Jeffrey T. Kuethe, Jinsong Hao, J. Cumming, 2016 .

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.

G. Kaczorowski, B. Priest, Haifeng Tang, 2012, ACS medicinal chemistry letters.