M. Frohn

发表

Diversity-oriented synthesis of polyketide natural products via iterative chemo- and stereoselective functionalization of polyenoates: development of a unified approach for the C(1-19) segments of lituarines A-C.

M. Duffey, Amos B. Smith, Shawn P. Walsh, 2005, Organic letters.

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.

J. B. Jordan, J. McCarter, M. Mujacic, 2016, ACS chemical biology.

Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors.

Jennifer E. Golden, R. Bürli, V. Viswanadhan, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.

R. Bürli, V. Viswanadhan, R. Hungate, 2008, Bioorganic & medicinal chemistry letters.

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents.

Jennifer E. Golden, R. Bürli, V. Viswanadhan, 2006, Bioorganic & medicinal chemistry letters.

New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.

R. Bürli, R. Hungate, P. Tagari, 2007, Bioorganic & medicinal chemistry letters.

A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides.

C. Dominguez, R. Hungate, Longbin Liu, 2005, The Journal of organic chemistry.

Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.

Jennifer E. Golden, R. Bürli, Matthew R. Lee, 2011, ACS medicinal chemistry letters.

The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.

T. Bush, M. Rong, K. Sham, 2013, Bioorganic & medicinal chemistry letters.

Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.

Matthew R. Lee, A. Tasker, K. Sham, 2012, ACS medicinal chemistry letters.

Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.

Matthew R. Lee, A. Tasker, M. Horner, 2012, Bioorganic & medicinal chemistry letters.

Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity.

Jennifer E. Golden, R. Bürli, K. Muller, 2012, Bioorganic & medicinal chemistry letters.

4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.

Matthew R. Lee, M. Horner, K. Sham, 2011, ACS medicinal chemistry letters.

Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1).

Jennifer E. Golden, R. Bürli, M. Lobera, 2011, ACS medicinal chemistry letters.

Highly Regio- and Enantioselective Monoepoxidation of Conjugated Dienes

Yian Shi, Zhi‐Xian Wang, M. Frohn, 1998 .

Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.

A. Tasker, K. Sham, A. Itano, 2012, Bioorganic & medicinal chemistry letters.

N-substituted azaindoles as potent inhibitors of Cdc7 kinase.

Guomin Yao, M. Bartberger, E. Doherty, 2013, Bioorganic & medicinal chemistry letters.

A Mild and Efficient Epoxidation of Olefins Using in Situ Generated Dimethyldioxirane at High pH.

Yian Shi, Zhi‐Xian Wang, M. Frohn, 1998, The Journal of organic chemistry.

An Efficient Catalytic Asymmetric Epoxidation Method

Yian Shi, Zhi‐Xian Wang, M. Frohn, 1997 .

Chiral Ketone-Catalyzed Asymmetric Epoxidation of Olefins

Yian Shi, M. Frohn, 2000 .

Total syntheses of the assigned structures of lituarines B and C.

M. Duffey, Amos B. Smith, K. Basu, 2008, Journal of the American Chemical Society.

Lituarine synthetic studies. An efficient, stereocontrolled construction of the common c(7-19) tricyclic spiroketal fragment.

A. Smith, M. Frohn, A. Smith, 2001, Organic letters.

Synthesis of 1,2:4,5‐Di‐O‐Isopropylidene‐D‐Erythro‐2,3‐Hexodiulo‐2,6‐Pyranose. A Highly Enantioselective Ketone Catalyst for Epoxidation

Yian Shi, Zhi‐Xian Wang, M. Frohn, 2003 .

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

N. Chen, J. McCarter, K. Rex, 2019, Journal of medicinal chemistry.

Structural Probing of Ketone Catalysts for Asymmetric Epoxidation

Yian Shi, Yong Tang, Zhi‐Xian Wang, 1998 .

A Dramatic pH Effect Leads to a Catalytic Asymmetric Epoxidation.

Yian Shi, Zhi‐Xian Wang, M. Frohn, 1997, The Journal of organic chemistry.

Asymmetric Epoxidation of trans‐β‐Methylstyrene and 1‐Phenylcyclohexene Using a D‐Fructose‐Derived Ketone: (R,R)‐trans‐β‐Methylstyrene Oxide and (R,R)‐1‐Phenylcyclohexene Oxide

Yian Shi, L. Shu, Zhi‐Xian Wang, 2003 .

The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.

N. Chen, D. Whittington, M. Bartberger, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.

E. Hu, R. Kunz, N. Chen, 2014, Bioorganic & medicinal chemistry.

N-substituted azaindoles as potent inhibitors of Cdc7 kinase.

Guomin Yao, M. Bartberger, E. Doherty, 2013, Bioorganic & medicinal chemistry letters.