J. R. Gnanaprakasam

发表

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

J. López-Barneo, T. Fan, A. N. Lane, 2022, Science Immunology.

Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality

R. Higashi, A. N. Lane, Jun J. Yang, 2022, bioRxiv.

De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function

S. Zheng, Yufeng Yao, Ruoning Wang, 2020, bioRxiv.

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

Tingting Wang, Vasilis Vasiliou, Ruohan Wu, 2018, eLife.

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

J. López-Barneo, T. Fan, D. Scott, 2021, bioRxiv.

Anacardic 6-pentadecyl salicylic acid induces apoptosis in breast cancer tumor cells, immunostimulation in the host and decreases blood toxic effects of taxol in an animal model.

L. Vega, J. R. Gnanaprakasam, L. López-Bañuelos, 2020, Toxicology and applied pharmacology.

A Metabolism Toolbox for CAR T Therapy

Ruoning Wang, Xuequn Xu, J. R. Gnanaprakasam, 2019, Front. Oncol..

Inosine is an alternative carbon supply that supports effector T cell proliferation and antitumor function under glucose restriction

A. Lane, T. Fan, M. Warmoes, 2019, bioRxiv.

MYC in Regulating Immunity: Metabolism and Beyond

Ruoning Wang, J.N. Rashida Gnanaprakasam, Ruoning Wang, 2017, Genes.

Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction

S. Zheng, A. Lane, T. Fan, 2020, Nature Metabolism.

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

Yufeng Yao, Ruoning Wang, G. Fan, 2020, Science advances.

The anacardic 6-pentadecyl salicylic acid induces macrophage activation via the phosphorylation of ERK1/2, JNK, P38 kinases and NF-κB.

E. Estrada-Muñiz, L. Vega, J. R. Gnanaprakasam, 2015, International immunopharmacology.

MYC and HIF in shaping immune response and immune metabolism.

Ruoning Wang, J. R. Gnanaprakasam, John Sherman, 2017, Cytokine & growth factor reviews.

The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation

Ruoning Wang, Xuyong Chen, Siwen Kang, 2023, Science advances.

Author response: Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

D. Green, Ying Chen, V. Vasiliou, 2018 .

The antineoplastic agent anacardic 6-pentadecyl salicylic acid produces immunomodulation in vivo via the activation of MAPKs.

E. Estrada-Muñiz, L. Vega, J. R. Gnanaprakasam, 2019, Toxicology and applied pharmacology.

Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response

R. Higashi, Jun J. Yang, Ruoning Wang, 2023, Nature Metabolism.