A. Brumwell

发表

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Dustin J Maly, R. Ghosh, F. R. Papa, 2018, bioRxiv.

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Dustin J Maly, R. Ghosh, F. R. Papa, 2018, bioRxiv.

Integrin (cid:2) 3 (cid:3) 1 – dependent (cid:3) -catenin phosphorylation links epithelial Smad signaling to cell contacts

H. Chapman, Ying-Ying Wei, Xiaopeng Li, 2009 .

Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis

P. Wolters, H. Chapman, Ying-Ying Wei, 2021, Thorax.

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice.

Arnoud Sonnenberg, A. Sonnenberg, H. Chapman, 2011, The Journal of clinical investigation.

Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis.

P. Wolters, J. Kreidberg, H. Chapman, 2008, The Journal of clinical investigation.

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells

P. Wolters, M. Matthay, H. Chapman, 2020, bioRxiv.

Human distal airways contain a multipotent secretory cell that can regenerate alveoli

Shanru Li, E. Morrisey, D. Kotton, 2022, Nature.

Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration.

H. Chapman, Julia R Jackson, A. Brumwell, 2020, Cell stem cell.

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

F. R. Papa, D. Sheppard, H. Chapman, 2021, bioRxiv.

Lineage-negative Progenitors Mobilize to Regenerate Lung Epithelium after Major Injury

Mark R. Looney, Fengchun Liu, D. Brownfield, 2014, Nature.

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

D. Sheppard, P. Wolters, H. Chapman, 2006, Proceedings of the National Academy of Sciences.

Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with β1 integrins

H. Chapman, Ying-Ying Wei, A. Brumwell, 2008, Journal of Cell Science.

Integrin α3β1–dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts

H. Chapman, Ying-Ying Wei, Xiaopeng Li, 2009, The Journal of cell biology.

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration

Jianming Xu, M. Matthay, H. Chapman, 2017, Nature Cell Biology.

Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline.

H. Chapman, Thomas J. Kim, K. Tan, 2013, American journal of respiratory cell and molecular biology.

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype

Julie B. Sneddon, Patty J. Lee, D. Jablons, 2018, The Journal of clinical investigation.

Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis.

A. Ramanathan, J. Campisi, F. Alimirah, 2019, JCI insight.

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells

P. Wolters, D. Kotton, C. L. Le Saux, 2021, Nature Cell Biology.

Tamoxifen Administration for Lineage Tracing Using CreERT2 mice

H. Chapman, A. Vaughan, A. Brumwell, 2015 .

A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

J. Golden, K. Jones, P. Wolters, 2023, bioRxiv.

Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia

D. McDonald, I. Kwan, D. Jablons, 2013, Oncogene.

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice.

Thiennu H. Vu, A. Sonnenberg, H. Chapman, 2011, Journal of Clinical Investigation.

Integrin Alpha6Beta4 Identifies An Adult Distal Lung Epithelial Cell Population With Progenitor Potential In Vivo

Thiennu H. Vu, T. Vu, W. Lorizio, 2011, Asian Test Symposium.