D. Shen

发表

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

H. Xu, Huahao Shen, S. Ying, 2022, Cell discovery.

Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity

Xiaohui Yu, Xiaoyu Jiang, L. Du, 2022, Proceedings of the National Academy of Sciences of the United States of America.

GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

David E. Gloriam, D. Gloriam, H. Xu, 2022, Molecular cell.

Structural basis of GPBAR activation and bile acid recognition

F. Nan, Yuemao Shen, Changtao Jiang, 2020, Nature.

Structural insights into human brain–gut peptide cholecystokinin receptors

C. Mao, Yan Zhang, Jiao Qin, 2022, Cell discovery.

Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes

Qiaojun He, C. Mao, Yan Zhang, 2022, Cell Research.

Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation

Zhihong Liu, Xiuwen Zhai, C. Mao, 2022, Nature Communications.

Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

Xinheng He, H. Xu, X. E. Zhou, 2022, Nature Communications.

Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor

Shuyang Zhang, Xi Cheng, H. Xu, 2022, bioRxiv.

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Yan Zhang, Hualiang Jiang, Sheng-Ce Tao, 2020, bioRxiv.

Multiomic Analysis Reveals Core Regulatory Mechanisms underlying Steroidal Glycoalkaloid Metabolism in Potato Tubers.

Huanjing Chen, Cai-Peng Yue, Shu-Ting Yu, 2021, Journal of agricultural and food chemistry.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

Hualiang Jiang, Shuyang Zhang, Gengfu Xiao, 2020, bioRxiv.

Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

Shuyang Zhang, Xi Cheng, Xinheng He, 2023, Nature Communications.

Structural basis for activation of the growth hormone-releasing hormone receptor

Hualiang Jiang, Suwen Zhao, Xi Cheng, 2020, Nature Communications.

Structures of the human dopamine D3 receptor-Gi complexes.

Hualiang Jiang, Xi-Ping Huang, B. Roth, 2021, Molecular cell.

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

Hualiang Jiang, Xi Cheng, Xinheng He, 2022, Nature Communications.

Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype

G. Hou, C. Mao, P. Xiao, 2021, Science Advances.

Structural basis of GPBAR activation and bile acid recognition

Xiaohui Yu, Yuemao Shen, Changtao Jiang, 2020, Nature.

Structural basis of bile acid receptor activation and Gs coupling

F. Nan, Yuemao Shen, Changtao Jiang, 2020, bioRxiv.

A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer

Yuelong Liang, Hong-Mei Yu, Xiujun Cai, 2021, Science Advances.

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

Tingjun Hou, Tianhua Zhou, Ming-Wei Wang, 2021, Cell Research.

Cryo-EM structures of inactive and active GABAB receptor

Jianfeng Liu, Chanjuan Xu, C. Mao, 2020, Cell Research.

Structural insights into the human D1 and D2 dopamine receptor signaling complexes

Hualiang Jiang, Xi-Ping Huang, B. Roth, 2021, Cell.

Structure and dynamics of the active human parathyroid hormone receptor-1

Tomoyuki Watanabe, H. Xu, L. Clark, 2019, Science.

Structural insights into the lipid and ligand regulation of serotonin receptors

David E. Gloriam, Hualiang Jiang, C. Robinson, 2021, Nature.

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Xinheng He, H. Xu, Qiu-feng Liu, 2020, Nature Communications.

Structural insights into lipid and ligand regulation of serotonin receptors

Hualiang Jiang, C. Robinson, D. Gloriam, 2019, Nature.

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

M. Rosenkilde, Suwen Zhao, H. Xu, 2020, Cell Research.

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors.

P. Sexton, H. Xu, Ming-Wei Wang, 2020, Molecular cell.

Structure and dynamics of the active human parathyroid hormone receptor-1.

C. Li, Tomoyuki Watanabe, H. Xu, 2019 .

Molecular mechanism of agonism and inverse agonism in ghrelin receptor

K. Hirata, C. Mao, Yan Zhang, 2022, Nature Communications.

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

Yi Jiang, Jing Yang, Caiping Tian, 2021, Nature.

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

H. Xu, W. An, Yi Jiang, 2021, Nature.

Structural basis of GABAB receptor–Gi protein coupling

J. Pin, P. Rondard, Jianfeng Liu, 2021, Nature.

Unsaturated bond recognition leads to biased signal in a fatty acid receptor

Chuan Wang, C. Mao, P. Xiao, 2023, Science.

Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1

H. Xu, Huahao Shen, S. Ying, 2021, Nature Chemical Biology.

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

R. Stevens, Ming-Wei Wang, W. Yin, 2021, bioRxiv.

Cryo-EM structures of inactive and Gi-coupled GABAB heterodimer

Jianfeng Liu, Chanjuan Xu, C. Mao, 2020, bioRxiv.

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Yi Jiang, H. Su, Guanghui Tian, 2020, Science.

Orthosteric and allosteric modulation of human HCAR2 signaling complex

C. Mao, Yan Zhang, Zhiwei Wang, 2023, Nature communications.