Nathan R. Kett

发表

Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.

K. K. Nanda, C. Lindsley, R. Spencer, 2017, Bioorganic & medicinal chemistry letters.

Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases.

S. Stirdivant, L. Kuo, P. Darke, 2005, Biochemistry.

Simplified synthesis of individual stereoisomers of the 4-hydroxynonenal adducts of deoxyguanosine.

Edward K. Hawkins, C. Rizzo, Nathan R Kett, 2013, Tetrahedron letters.

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe.

A. Waterson, C. Lindsley, E. Delpire, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists.

G. McGaughey, J. Renger, A. Gotter, 2010, Bioorganic & medicinal chemistry letters.

Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives.

Sarah A. Scott, Anna L. Blobaum, A. Waterson, 2018, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.

Kenneth D Anderson, K. K. Nanda, N. Liverton, 2006, Journal of medicinal chemistry.

Imidazopyridine CB2 agonists: optimization of CB2/CB1 selectivity and implications for in vivo analgesic efficacy.

K. K. Nanda, D. Henze, Suzie Yeh, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists.

D. Sheffler, C. Lindsley, P. Conn, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).

Scott T. Harrison, Sujata Sharma, J. Barrow, 2015, ACS medicinal chemistry letters.

Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).

Peter Chase, P Jeffrey Conn, Craig W Lindsley, 2013, Journal of medicinal chemistry.