S. Traeger

发表

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) which Demonstrate HDL-C Increase In Vivo.

David S. Taylor, K. Behnia, E. Liu, 2020, Journal of medicinal chemistry.

The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton's tyrosine kinase.

A. Tymiak, Yingru Zhang, M. Obermeier, 2017, Journal of chromatography. A.

Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.

J. Tokarski, B. Koplowitz, J. Hunt, 2005, Bioorganic & medicinal chemistry letters.

Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry.

Darpandeep Aulakh, Amy A Sarjeant, P. Cheng, 2021, Organic letters.

Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro

A. D. Rodrigues, Hongjiang Zhang, B. Wen, 2008, Drug Metabolism and Disposition.

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.

A. Mathur, P. Stein, M. Conder, 2001, Journal of Medicinal Chemistry.

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable IKs blockers

A. Mathur, P. Stein, Mark A. Smith, 2001 .

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.

L. Mueller, S. Sheriff, David K. Williams, 2006, Bioorganic & medicinal chemistry letters.

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.

Vijay T. Ahuja, Derek J. Norris, J. Tokarski, 2021, Journal of medicinal chemistry.

Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1.

Kimberly A. Foster, J. Fargnoli, J. Hunt, 2021, ACS medicinal chemistry letters.

Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.

J. Fargnoli, R. Talbott, S. Emanuel, 2015, Journal of medicinal chemistry.

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.

C. Chu, S. Jusuf, Yanou Yang, 2021, Journal of medicinal chemistry.

One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.

Michael A. Galella, P. Stein, N. Grazier, 2004, The Journal of organic chemistry.

Evolution of a Scale-Up Synthesis to a Potent GluN2B Inhibitor and Its Prodrug

Michael A. Galella, A. Mathur, M. Dabros, 2018, Organic Process Research & Development.

One-pot two step synthesis of 5-cyano-dihydropyrimidinones using polyphosphate ester

David K. Williams, R. Schmidt, L. Lombardo, 2008 .

Solid-phase synthesis of 5-substituted amino pyrazoles.

M. Poss, M. Hermsmeier, C. Cooper, 2005, Journal of combinatorial chemistry.

Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.

W. Humphreys, G. Grover, P. Sleph, 1997, Journal of medicinal chemistry.

One‐Pot Two Step Synthesis of 5‐Cyano‐dihydropyrimidinones Using Polyphosphate Ester.

David K. Williams, R. Schmidt, L. Lombardo, 2008 .

1,2,3,4-TETRAHYDRO-8-HYDROXYMANZAMINES, ALKALOIDS FROM TWO DIFFERENT HAPLOSCLERID SPONGES

M. Jaspars, P. Crews, F. Schmitz, 1994 .

Synthesis of an adenine N-3 substituted CBI adduct by alkylation of adenine with a 1-iodomethylindoline seco-CBI precursor

A. Allentoff, M. Wallace, S. Bonacorsi, 2018, Tetrahedron.

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked

Michael A. Galella, K. McIntyre, J. Barrish, 2016, Journal of medicinal chemistry.

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

K. Dickinson, G. Grover, P. Sleph, 1998, Journal of medicinal chemistry.

Efficient Molar-Scale Synthesis of 1-Methyl-5-acylimidazole Triflic Acid Salts

A. P. Skoumbourdis, Bang-Chi Chen, S. Traeger, 2000 .

Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.

D. J. Nelson, J. Barrish, S. Mandlekar, 2015, ACS medicinal chemistry letters.

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists.

A. Tebben, P. Carter, J. Duncia, 2008, Bioorganic & medicinal chemistry letters.

Diastereoselective oxidation of sulfides to sulfoxides. Synthesis of novel C-6 sulfoxy tetrahydromevinic acids

E. Gordon, S. Chao, R. Varma, 1994 .

Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen.

Darpandeep Aulakh, M. Davies, B. Ellsworth, 2022, Organic letters.

[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists.

Michael A. Galella, G. Trainor, Weifang Shan, 2016, Bioorganic & medicinal chemistry letters.

Efficient Molar‐Scale Synthesis of 1‐Methyl‐5‐acylimidazole Triflic Acid Salts.

A. P. Skoumbourdis, Bang-Chi Chen, G. Rovnyak, 2001 .

Novel Bishomoscalarane Sesterterpenes from the Sponge Phyllospongia foliascens

Xiong Fu, F. Schmitz, E. O. Pordesimo, 1991 .

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

P. M. Davis, V. Goldfarb, D. Cheney, 2006, Journal of medicinal chemistry.

alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.

E. Sieber-McMaster, R. Lawrence, T. Harrity, 1996, Journal of medicinal chemistry.

Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.

Michael G. Yang, Michael A. Galella, J. Barrish, 2019, ACS medicinal chemistry letters.

Synthesis and Biological Evaluation of Biaryl Alkyl Ethers as Inhibitors of IDO1.

Xin Li, J. Hunt, L. Jayaraman, 2023, Bioorganic & medicinal chemistry letters.

Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes.

Maximilian D Palkowitz, Darpandeep Aulakh, B. Ellsworth, 2023, Organic Letters.

Confirmation That Cytochrome P450 2C8 (CYP2C8) Plays a Minor Role in (S)-(+)- and (R)-(-)-Ibuprofen Hydroxylation in Vitro

Hongjiang Zhang, B. Wen, Shu-Ying Chang, 2008, Drug Metabolism and Disposition.