Jonathan W. Adams

发表

Angiotensin-Converting Enzyme C-Terminal Catalytic Domain Is the Main Site of Angiotensin I Cleavage In Vivo

M. Capecchi, P. Corvol, K. Bernstein, 2008, Hypertension.

Six Truisms Concerning ACE and the Renin-Angiotensin System Educed From the Genetic Analysis of Mice

K. Bernstein, Xiao Z. Shen, S. Fuchs, 2005, Circulation research.

PTH expands short-term murine hemopoietic stem cells through T cells.

L. Calvi, R. Pacifici, R. DiPaolo, 2012, Blood.

T Cell–Expressed CD40L Potentiates the Bone Anabolic Activity of Intermittent PTH Treatment

R. Pacifici, M. Weitzmann, Mingcan Yu, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss

H. Kronenberg, R. Pacifici, B. Bedi, 2010, PloS one.

Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH

K. Baek, R. Pacifici, B. Bedi, 2012, Proceedings of the National Academy of Sciences.

Vascular wall ACE is not required for atherogenesis in ApoE(-/-) mice.

D. Weiss, S. Fuchs, K. Bernstein, 2010, Atherosclerosis.

Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells.

C. Coopersmith, R. Pacifici, M. Weitzmann, 2021, The Journal of clinical investigation.

The Sclerostin‐Independent Bone Anabolic Activity of Intermittent PTH Treatment Is Mediated by T‐Cell–Produced Wnt10b

R. Pacifici, M. Weitzmann, A. M. Tyagi, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression

R. Pacifici, M. Weitzmann, Mingcan Yu, 2018, Immunity.

Expression and in vitro evaluation of rhesus macaque wild type (wt) and modified CC chemokines

C. Hillyer, W. Cruikshank, G. Brice, 1998, Journal of medical primatology.

New approaches to genetic manipulation of mice: tissue-specific expression of ACE.

K. Bernstein, Hong D. Xiao, J. Cole, 2003, American journal of physiology. Renal physiology.

Parathyroid hormone–dependent bone formation requires butyrate production by intestinal microbiota

Hamid Y. Dar, R. Pacifici, M. Weitzmann, 2019 .

Microbiota dependent production of butyrate is required for the bone anabolic activity of PTH.

Hamid Y. Dar, R. Pacifici, M. Weitzmann, 2020, The Journal of clinical investigation.

R13, a TrkB Agonist Prodrug, Inhibits Asparagine Endopeptidase (AEP) and Increases Osteoprotegerin (OPG), Preventing Bone Loss

K. Ye, Xia Liu, R. Pacifici, 2021 .

The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone

C. Coopersmith, R. Faccio, R. Pacifici, 2022, The Journal of clinical investigation.

Newly recognized physiologic and pathophysiologic actions of the angiotensin-converting enzyme

K. Bernstein, S. Fuchs, Hong D. Xiao, 2004, Current hypertension reports.

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

K. Ye, Xia Liu, R. Pacifici, 2022, Nature Communications.

New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice

S. Billet, K. Bernstein, E. Bernstein, 2008, Journal of Molecular Medicine.

IL‐17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH‐Induced Bone Loss and Enhances Osteocytic RANKL Production

T. Bellido, R. Pacifici, M. Weitzmann, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The use of knockout mouse technology to achieve tissue selective expression of angiotensin converting enzyme.

K. Bernstein, Xiao Z. Shen, S. Fuchs, 2004, Journal of molecular and cellular cardiology.

Male fertility is dependent on dipeptidase activity of testis ACE

M. Capecchi, L. Muller, P. Corvol, 2005, Nature Medicine.

Establishing the role of angiotensin-converting enzyme in renal function and blood pressure control through the analysis of genetically modified mice.

K. Bernstein, Xiao Z. Shen, S. Fuchs, 2005, Journal of the American Society of Nephrology : JASN.

The gut microbiota is a transmissible determinant of skeletal maturation

Hamid Y. Dar, R. Pacifici, Mingcan Yu, 2021, eLife.

AWARD NUMBER: W81XWH-15-1-0239 TITLE: Alterations in Gut Microbiota and Post-Traumatic Osteoarthritis PRINCIPAL INVESTIGATOR: Dr. Christopher Hernandez CONTRACTING ORGANIZATION: CORNELL

Rheinallt M. Jones, Jonathan W. Adams, J. Volpon, 2016 .

PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

T. Denning, R. Pacifici, M. Weitzmann, 2020, Nature Communications.

Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics.

J. Mulle, B. Chassaing, A. Gewirtz, 2016, The Journal of clinical investigation.

Mice Lacking Endothelial ACE: Normal Blood Pressure With Elevated Angiotensin II

M. Capecchi, P. Corvol, K. Bernstein, 2003, Hypertension.

Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand

R. Pacifici, B. Bedi, M. Weitzmann, 2010, Proceedings of the National Academy of Sciences.

Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice*

M. Capecchi, P. Corvol, K. Bernstein, 2004, Journal of Biological Chemistry.

Micropuncture determination of nephron function in mice without tissue angiotensin-converting enzyme.

K. Bernstein, J. Schnermann, S. Hashimoto, 2005, American journal of physiology. Renal physiology.

Hydrogen Sulfide Is a Novel Regulator of Bone Formation Implicated in the Bone Loss Induced by Estrogen Deficiency

G. Lisignoli, J. Calvert, R. Pacifici, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Regulatory T cells are expanded by Teriparatide treatment in humans and mediate intermittent PTH‐induced bone anabolism in mice

R. Pacifici, R. DiPaolo, M. Weitzmann, 2018, EMBO reports.

Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain

C. Kuan, K. Griendling, B. Lassègue, 2018, Journal of Neuroinflammation.

Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B.

L. Calvi, R. Pacifici, M. Weitzmann, 2013, Blood.

IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.

R. Pacifici, G. Isaia, M. Weitzmann, 2015, Cell metabolism.