Yang Tang

发表

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.

Y. Satoh, B. Bennett, D. Giegel, 2012, Bioorganic & medicinal chemistry letters.

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.

L. Hamann, L. LeBrun, B. Cathers, 2020, Journal of medicinal chemistry.

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.

P. Schafer, K. Blease, J. Leisten, 2009, Journal of medicinal chemistry.

CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia.

L. LeBrun, B. Cathers, M. Pourdehnad, 2021, Journal of medicinal chemistry.

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

J. Copland, H. Tun, P. Huang, 2013, PloS one.

A proposed screening paradigm for discovery of covalent inhibitor drugs.

A. Kulkarni, M. Moghaddam, Z. O’Brien, 2014, Drug metabolism letters.

New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment.

T. Zhu, Wenhao Hu, Yang Tang, 2016, Bioorganic & medicinal chemistry letters.

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.

Philip Chamberlain, Y. Satoh, B. Bennett, 2012, Bioorganic & medicinal chemistry letters.

Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.

P. Schafer, Alexander L. Ruchelman, L. Corral, 2013, Bioorganic & medicinal chemistry letters.

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.

L. LeBrun, Dan Zhu, B. Pagarigan, 2017, Journal of medicinal chemistry.

Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.

B. Cathers, S. Sakata, J. Leisten, 2012, Bioorganic & medicinal chemistry letters.

A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation

K. Miyazawa, B. Bennett, L. LeBrun, 2016, PloS one.